Results 301 to 310 of about 82,521 (353)

Drug Synergism: Its Detection and Applications

The Journal of Pharmacology and Experimental Therapeutics, 2001
Two drugs that produce overtly similar effects will sometimes produce exaggerated or diminished effects when used concurrently. A quantitative assessment is necessary to distinguish these cases from simply additive action. This distinction is based on the classic pharmacologic definition of additivity that, briefly stated, means that each constituent ...
openaire   +2 more sources

A Fatality Due to Drug Synergism

Medicine, Science and the Law, 1982
Thioridazine is a phenothiazine tranquillizer with specificity for psychotherapeutic action. It is well tolerated but will induce changes in myocardial repolarization which are further aggravated in the presence of low blood potassium levels. Fatalities due to overdosage of thioridazine are rare and those associated with therapeutic dosage and cross ...
openaire   +2 more sources

Synergism of Three Antimicrobial Drugs

Nature, 1966
COMBINED therapy with two or more antibacterial drugs may be useful in the treatment of an individual case, and in discouraging the development of resistance1. A formula was previously presented which could be used in evaluating the combined effect of two drugs2.
D, Kaplan, W, Koch
openaire   +2 more sources

A Test for Synergism Between Two Drugs

Applied Statistics, 1976
A likelihood ratio test is devised to detect the presence of synergism between two drugs which have similar actions. An example is given.
S. C. Darby, M. J. Ellis
openaire   +1 more source

The interaction index: a measure of drug synergism

Pain, 2002
Two drugs used in combination may produce enhanced or reduced effects. The degree of enhancement or reduction is measured from the interaction index (gamma), a quantity that indicates the changed potency of the combination. The index is therefore a quantitative marker for the drug combination and effect metric used.
openaire   +2 more sources

Informatics of Drug Synergism in Naturally Occurring Anticancer Agents

Recent Patents on Anti-Cancer Drug Discovery, 2011
Cancer is a multi-factorial disease resulting in uncontrolled division of body cells, with difficult and complex suppression. The main treatment strategy for this disease depends on killing of tumor cells that usually exist in the proximity of normal body cells. During the course of treatment, the healthy cells should not be affected by the toxic doses
Ghazaleh, Ghavami, Mohammad R, Kazemali, Soroush, Sardari   +2 more
openaire   +2 more sources

Synergism between staurosporine and drugs inducing endoplasmic reticulum stress

Biochemical Pharmacology, 2006
Drugs causing endoplasmic reticulum or mitochondrial dysfunction may trigger apoptosis in eukaryotic cells. The thiol reagent dithiothreitol (DTT) belongs to the first group whereas the protein kinases inhibitor staurosporine acts on mitochondria. Since the endoplasmic reticulum and the mitochondrial pathways of apoptosis may converge in common steps ...
CUSINATO, FEDERICO, PIGHIN, ISABELLA, LUCIANI, SISTO, TREVISI, LUCIA   +3 more
openaire   +2 more sources

Synergism in Drug Treatment of Familial Hypercholesterolemia

1980
The monogenic disorder familial hypercholesterolemia (FH) is associated with a high risk of premature coronary arteriosclerosis, largely attributable to a 2-3 fold increase in levels of low density lipoproteins (LDL) in serum. Heretofore, no regimen of drug therapy or surgical intervention has been reported which is capable of lowering levels of low ...
J. P. Kane, P. Tun, M. J. Malloy, R. J. Havel   +3 more
openaire   +1 more source

Quantitative Aspects of Drug Antagonism and of Drug Synergism

1937
It was shown in the last chapter that, in populations of animals, changes in sensitivity to drugs can be produced by a wide variety of causes, and that in some cases variations in sensitivity occur for which the causes are unknown. It seems justifiable to assume that if the condition of organisms is altered by the administration of one drug, then this ...
openaire   +1 more source

Current Methods for Quantifying Drug Synergism.

Proteomics & bioinformatics : current research
The effectiveness of drug combinations for treatment of a variety of complex diseases is well established. "Drug cocktail" treatments are often prescribed to improve the overall efficacy, decrease toxicity, alter pharmacodynamics, etc in an overall treatment strategy.
Jun, Ma, Alison, Motsinger-Reif
openaire   +1 more source