Results 1 to 10 of about 1,488,673 (145)

Miltefosine as a PPM1A activator improves AD-like pathology in mice by alleviating tauopathy via microglia/neurons crosstalk

Brain, Behavior, & Immunity - Health, 2022
Alzheimer's disease (AD) is a progressively neurodegenerative disease without effective treatment. Here, we reported that the levels of expression and enzymatic activity of phosphatase magnesium-dependent 1A (PPM1A) were both repressed in brains of AD ...
Jianlu Lv, Xingyi Shen, Xinya Shen, Xiaoqian Li, Zhuoying Jin, Xingnan Ouyang, Jian Lu, Danyang Zhu, Jiaying Wang, Xu Shen   +9 more
doaj   +1 more source

Mitochondria-Targeted Drugs [PDF]

Current Molecular Pharmacology, 2019
Background:Targeting of drugs to the subcellular compartments represents one of the modern trends in molecular pharmacology. The approach for targeting mitochondria was developed nearly 50 years ago, but only in the last decade has it started to become widely used for delivering drugs.
Zinovkin, Roman A., Zamyatnin, Andrey A.
openaire   +2 more sources

Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates

Nature Communications, 2021
How phase separation participates in mitophagy remains unclear. Here the authors show that Nur77 and p62/SQSTM1 through “head-to-head” and “tail-to-tail” interactions form membraneless condensates capable of sequestering dysfunctional mitochondria and ...
Shuang-zhou Peng, Xiao-hui Chen, Si-jie Chen, Jie Zhang, Chuan-ying Wang, Wei-rong Liu, Duo Zhang, Ying Su, Xiao-kun Zhang   +8 more
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Drug targeting

European Journal of Pharmaceutical Sciences, 2000
The main problems currently associated with systemic drug administration are: even biodistribution of pharmaceuticals throughout the body; the lack of drug specific affinity toward a pathological site; the necessity of a large total dose of a drug to achieve high local concentration; non-specific toxicity and other adverse side-effects due to high drug
G. E. Francis, Cristina Delgado
openaire   +3 more sources

Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation

BMC Biology, 2023
Background The maturation of microRNAs (miRNAs) successively undergoes Drosha, Dicer, and Argonaute ˗mediated processing, however, the intricate regulations of the individual miRNA maturation are largely unknown.
Xiaohong Ye, Yun Yang, Jiayue Yao, Mo Wang, Yixin Liu, Guobin Xie, Zhiping Zeng, Xiao-kun Zhang, Hu Zhou   +8 more
doaj   +1 more source

Synthesis and Anti-Hepatoma Activities of U12 Derivatives Arresting G0/G1 Phase and Inducing Apoptosis by PI3K/AKT/mTOR Pathway

Pharmaceuticals, 2022
Ursodeoxycholic acid (UDCA) is a first-line clinical drug for the treatment of liver diseases. U12, a derivative of UDCA, showed effective anti-hepatoma activities in previous works.
Renjing Yang, Chunchun Du, Ting Cao, Guanghui Wang, Xin Jiang, Jun Gao, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian, Haifeng Chen   +10 more
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Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity

Pharmaceuticals, 2022
Vernonia amygdalina Del. is a traditional medicinal plant and vegetable originating from tropical Africa. The phytochemical investigation of V. amygdalina led to eight undescribed polyhydric stigmastane-type steroids, vernonin M–T (1–8).
Xiangzhong Liu, Mi Zhou, Shoulun He, Qiannan Xu, Chunchun Du, Honghong Zhu, Ting Lin, Guanghui Wang, Wenjing Tian, Haifeng Chen   +9 more
doaj   +1 more source

Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer’s disease-like pathology

Alzheimer’s Research & Therapy, 2020
Background Amyloid β (Aβ)-directed immunotherapy has shown promising results in preclinical and early clinical Alzheimer’s disease (AD) trials, but successful translation to late clinics has failed so far.
Kathrin Gnoth, Anke Piechotta, Martin Kleinschmidt, Sandra Konrath, Mathias Schenk, Nadine Taudte, Daniel Ramsbeck, Vera Rieckmann, Stefanie Geissler, Rico Eichentopf, Susan Barendrecht, Maike Hartlage-Rübsamen, Hans-Ulrich Demuth, Steffen Roßner, Holger Cynis, Jens-Ulrich Rahfeld, Stephan Schilling   +16 more
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Unprecedented Monoterpenoid Polyprenylated Acylphloroglucinols with a Rare 6/6/5/4 Tetracyclic Core, Enhanced MCF-7 Cells’ Sensitivity to Camptothecin by Inhibiting the DNA Damage Response

Biomedicines, 2021
(±)-Hypersines A–C (1–3), the three pairs of enantiomerically pure monoterpenoid polyprenylated acylphloroglucinols with an unprecedented 6/6/5/4 fused ring system, were isolated from Hypericum elodeoides.
Xiang-Zhong Liu, Mi Zhou, Chun-Chun Du, Hong-Hong Zhu, Xi Lu, Shou-Lun He, Guang-Hui Wang, Ting Lin, Wen-Jing Tian, Hai-Feng Chen   +9 more
doaj   +1 more source

Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis

Nature Communications, 2021
Inhibitor of Differentiation 1 (ID1) is an oncogene for colorectal cancer. Here, the authors show a complex interplay between nuclear receptor Nur77 and Transforming Growth Factor-β (TGFβ) to regulate ID1 expression at both transcriptional and post ...
Boning Niu, Jie Liu, Ben Lv, Jiacheng Lin, Xin Li, Chunxiao Wu, Xiaohua Jiang, Zhiping Zeng, Xiao-kun Zhang, Hu Zhou   +9 more
doaj   +1 more source