Results 11 to 20 of about 1,488,693 (165)

Clinical proteomic analysis of scrub typhus infection

Clinical Proteomics, 2018
Background Scrub typhus is an acute and febrile infectious disease caused by the Gram-negative α-proteobacterium Orientia tsutsugamushi from the family Rickettsiaceae that is widely distributed in Northern, Southern and Eastern Asia. In the present study,
Edmond Changkyun Park, Sang-Yeop Lee, Sung Ho Yun, Chi-Won Choi, Hayoung Lee, Hyun Seok Song, Sangmi Jun, Gun-Hwa Kim, Chang-Seop Lee, Seung Il Kim   +9 more
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Antibiotic treatment modulates protein components of cytotoxic outer membrane vesicles of multidrug-resistant clinical strain, Acinetobacter baumannii DU202

Clinical Proteomics, 2018
Background Outer membrane vesicles (OMVs) of Acinetobacter baumannii are cytotoxic and elicit a potent innate immune response. OMVs were first identified in A. baumannii DU202, an extensively drug-resistant clinical strain.
Sung Ho Yun, Edmond Changkyun Park, Sang-Yeop Lee, Hayoung Lee, Chi-Won Choi, Yoon-Sun Yi, Hyun-Joo Ro, Je Chul Lee, Sangmi Jun, Hye-Yeon Kim, Gun-Hwa Kim, Seung Il Kim   +11 more
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Ag nanocomposite hydrogels with immune and regenerative microenvironment regulation promote scarless healing of infected wounds

Journal of Nanobiotechnology, 2023
Background Bacterial infection, complex wound microenvironment and persistent inflammation cause delayed wound healing and scar formation, thereby disrupting the normal function and appearance of skin tissue, which is one of the most problematic clinical
Yihui Zhang, Jian Kang, Xuan Chen, Wenkai Zhang, Xiangqi Zhang, Wei Yu, Wei-En Yuan   +6 more
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Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy

Molecular & Cellular Oncology, 2018
Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its ...
Mengjie Hu, Gulimiran Alitongbieke, Ying Su, Hu Zhou, Xiao-kun Zhang   +4 more
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Quality Control of Psoralea corylifolia L. Based on High-Speed Countercurrent Chromatographic Fingerprinting

Molecules, 2020
Traditional Chinese medicine (TCM)has played an important role in promoting the health of Chinese people. The TCM Psoralea corylifolia L. has been used in the treatment of various kinds of diseases including enuresis, vitiligo, and calvities.
Xiaoxue Wu, Xuemin Gao, Xinmei Liu, Shuyi Zhang, Huayu Yang, Xuan Zhu, Hua Song, Funan Li, Qing Chen   +8 more
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Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα

Nature Communications, 2017
The transcription factor retinoid X receptor-alpha (RXRα) can also form homotetramers. Here the authors show that the anti-cancer agent K-80003 selectively inhibits the nongenomic action of N-terminally-cleaved RXRα in tumour cells by stabilizing its ...
Liqun Chen, Alexander E. Aleshin, Gulimiran Alitongbieke, Yuqi Zhou, Xindao Zhang, Xiaohong Ye, Mengjie Hu, Gaoang Ren, Ziwen Chen, Yue Ma, Duo Zhang, Shuai Liu, Weiwei Gao, Lijun Cai, Lingjuan Wu, Zhiping Zeng, Fuquan Jiang, Jie Liu, Hu Zhou, Gregory Cadwell, Robert C. Liddington, Ying Su, Xiao-kun Zhang   +22 more
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Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ERα to inhibit RANKL signaling

Acta Pharmaceutica Sinica B, 2021
Although different types of drugs are available for postmenopausal osteoporosis, the limitations of the current therapies including drug resistances and adverse effects require identification of novel anti-osteoporosis agents.
Keqi Wang, Yongyan Chen, Shuo Gao, Maosi Wang, Mengmeng Ge, Qian Yang, Mingkai Liao, Lin Xu, Junjie Chen, Zhiping Zeng, Haifeng Chen, Xiao-kun Zhang, Ting Lin, Hu Zhou   +13 more
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Antihyperuricemic effect of mangiferin aglycon derivative J99745 by inhibiting xanthine oxidase activity and urate transporter 1 expression in mice

Acta Pharmaceutica Sinica B, 2018
A mangiferin aglycon derivative J99745 has been identified as a potent xanthine oxidase (XOD) inhibitor by previous in vitro study. This study aimed to evaluate the hypouricemic effects of J99745 in experimental hyperuricemia mice, and explore the ...
Zhizhen Qin, Shoubao Wang, Yihuang Lin, Ying Zhao, Shengqian Yang, Junke Song, Tao Xie, Jinlong Tian, Song Wu, Guanhua Du   +9 more
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Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

Nature Communications, 2019
The truncated form of retinoid X receptor-alpha is found in cancer. Here, the authors show that this mutant receptor promotes colorectal tumorigenesis by activation of NF-κB in myeloid cells, leading to subsequent IL-6-induced STAT3 activation in ...
Xiaohong Ye, Hua Wu, Luoyan Sheng, Yi-xin Liu, Fang Ye, Mo Wang, Hu Zhou, Ying Su, Xiao-kun Zhang   +8 more
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Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish

Frontiers in Endocrinology, 2022
Orphan nuclear receptor Nur77 has been reported to be implicated in a diverse range of metabolic processes, including carbohydrate metabolism and lipid metabolism.
Yang Xu, Juanjuan Tian, Qi Kang, Qi Kang, Hang Yuan, Chengdong Liu, Zhehui Li, Jie Liu, Mingyu Li   +8 more
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