Results 21 to 30 of about 1,488,693 (165)

Anticancer therapeutics: “Addictive” targets, multi-targeted drugs, new drug combinations

Drug Resistance Updates, 2005
The annual meeting of the American Association for Cancer Research (AACR) provided a panoramic view of new developments and trends in cancer research. In the area of new drug development, a recurrent theme was receptor tyrosine kinase (TK) inhibitors, with multi-targeted, small molecule inhibitors - highly potent against a family of receptors such as ...
Broxterman, H.J., Georgopapadakou, NH
openaire   +3 more sources

Protocol to identify centrosome-associated transcription factors during mitosis in mammalian cell lines

STAR Protocols, 2021
Summary: During eukaryotic cell mitosis, the nuclear envelope disintegrates and transcription factors are dissociated from condensed chromosomes. Here, we describe a protocol to study centrosomal translocation of nuclear receptor RXRα.
Guobin Xie, Yuqi Zhou, Mingxuan Du, Qiqiang Wang, Jiajin Yi, Xiao-kun Zhang   +5 more
doaj   +1 more source

In vitro and in vivo evaluation of macromolecular prodrug GC-FUA based nanoparticle for hepatocellular carcinoma chemotherapy

Drug Delivery, 2017
A novel type of macromolecular prodrug delivery system is reported in this research. The N-galactosylated-chitosan-5-fluorouracil acetic acid conjugate (GC-FUA) based nanoparticle delivery system was evaluated in vitro and in vivo. Biocompatibility of GC-
Can Huang, Na-Mei Li, Pei Gao, Sa Yang, Qian Ning, Wen Huang, Zhi-Ping Li, Peng-Ju Ye, Li Xiang, Dong-Xiu He, Xiang-Wen Tan, Cui-Yun Yu   +11 more
doaj   +1 more source

Development of Polymeric Micelles of Oleanolic Acid and Evaluation of Their Clinical Efficacy

Nanoscale Research Letters, 2020
Oleanolic acid has been used only as a subsidiary agent in cosmetic products. The aim of the study is to show the effect of oleanolic acid as an active ingredient for the alleviation of wrinkles in humans and to develop a polymeric micelle formulation ...
Joo Young An, Hee Seon Yang, Na Rae Park, Tae-sung Koo, Bungchul Shin, Eun Hee Lee, Sun Hang Cho   +6 more
doaj   +1 more source

Gold Nanocluster-Based Fluorometric Banoxantrone Assay Enabled by Photoinduced Electron Transfer

Nanomaterials, 2022
Monitoring the blood concentration of banoxantrone (AQ4N) is important to evaluate the therapeutic efficacy and side effects of this new anticancer prodrug during its clinical applications.
Kai-Yuan Huang, Wen-Hui Weng, Xin Huang, Hong-Xiang Huang, Hamada A. A. Noreldeen, Hao-Hua Deng, Wei Chen   +6 more
doaj   +1 more source

A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice

Alzheimer’s Research & Therapy, 2023
Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain.
Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W. Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cynis   +20 more
doaj   +1 more source

Multi-omics elucidation of KDM5C, KDM6A, and KMT2B roles in cancer epigenetic dysregulation and transcriptional reprogramming

Communications Biology
Histone-modifying enzymes (HMEs) are critical regulators of tumorigenesis through epigenetic reprogramming. While mutations in HMEs are recognized drivers of cancer epigenome dysregulation, systematic comparative analyses of their mutational impacts and ...
Tengjiao Li, Lichen Wang, Shoufeng Duan, Xinyu Cui, Chunqing Fu, Jinglei Hu, Lin Li   +6 more
doaj   +1 more source

Ultrasound‐controlled drug release and drug activation for cancer therapy

Exploration, 2021
Traditional chemotherapy suffers from severe toxicity and side effects that limit its maximum application in cancer therapy. To overcome this challenge, an ideal treatment strategy would be to selectively control the release or regulate the activity of ...
Li Tu, Zhihuan Liao, Zheng Luo, Yun‐Long Wu, Andreas Herrmann, Shuaidong Huo   +5 more
doaj   +1 more source

Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Targeting metalloproteinases has been in the focus of drug design for a long time. However, meprin α and β emerged as potential drug targets just recently and are linked to several diseases with different pathological background.
Kathrin Tan, Christian Jäger, Stefanie Geissler, Dagmar Schlenzig, Mirko Buchholz, Daniel Ramsbeck   +5 more
doaj   +1 more source

Drug target validation: Hitting the target [PDF]

Nature, 2003
The route to new therapeutics often ends in costly failure. The secret of success is the rapid and accurate identification of drug targets with true potential, says Caitlin Smith.
openaire   +2 more sources