Results 31 to 40 of about 1,488,693 (165)

Desloratadine as the selective 5HT2AR antagonist suppresses neutrophil extracellular traps formation to ameliorate diabetic peripheral neuropathy pathology

Journal of Neuroinflammation
Diabetic peripheral neuropathy (DPN) is a common diabetic complication with a obscure and complicated pathogenesis. Here, we determined that 5-hydroxytryptamine receptor 2 A (5HT2AR) is selectively and pathologically elevated in the sciatic nerve (SN ...
Dayun Lu, Yuan Ruan, Fan Zhou, Yan Ma, Jieru Chang, Yuxi Wei, Rui Xu, Jiaying Wang, Xu Shen   +8 more
doaj   +1 more source

Drug-drug relationship based on target information: application to drug target identification [PDF]

BMC Systems Biology, 2011
Drugs that bind to common targets likely exert similar activities. In this target-centric view, the inclusion of richer target information may better represent the relationships between drugs and their activities. Under this assumption, we expanded the "common binding rule" assumption of QSAR to create a new drug-drug relationship score (DRS).Our ...
Park, KW Park, Keun-Wan, Kim, DS Kim, Dong-Sup   +1 more
openaire   +3 more sources

Development and Validation of an Ultra-Performance Liquid Chromatography Method for the Determination of Wedelolactone in Rat Plasma and its Application in a Pharmacokinetic Study

Molecules, 2019
Wedelolactone is a coumarin ether with significant hepatoprotective effects. However, there are few pharmacokinetic studies of wedelolactone, which will affect the studies of its efficacy and potential toxicity.
Qing Chen, Xiaoxue Wu, Xuemin Gao, Hua Song, Xuan Zhu   +4 more
doaj   +1 more source

Rab26 suppresses migration and invasion of breast cancer cells through mediating autophagic degradation of phosphorylated Src

Cell Death and Disease, 2021
Rab proteins play crucial roles in membrane trafficking. Some Rab proteins are implicated in cancer development through regulating protein sorting or degradation. In this study, we found that the expression of Rab26 is suppressed in the aggressive breast
Huiying Liu, Yuxia Zhou, Hantian Qiu, Ruijuan Zhuang, Yang Han, Xiaoqing Liu, Xi Qiu, Ziyan Wang, Liju Xu, Ran Tan, Wanjin Hong, Tuanlao Wang   +11 more
doaj   +1 more source

Chrysomycin A Regulates Proliferation and Apoptosis of Neuroglioma Cells via the Akt/GSK-3β Signaling Pathway In Vivo and In Vitro

Marine Drugs, 2023
Glioblastoma (GBM) is a major type of primary brain tumor without ideal prognosis and it is therefore necessary to develop a novel compound possessing therapeutic effects.
Dong-Ni Liu, Man Liu, Shan-Shan Zhang, Yu-Fu Shang, Wen-Fang Zhang, Fu-Hang Song, Hua-Wei Zhang, Guan-Hua Du, Yue-Hua Wang   +8 more
doaj   +1 more source

6-Aza-2-Thio-Thymine Stabilized Gold Nanoclusters as Photoluminescent Probe for Protein Detection

Nanomaterials, 2020
This study puts forward an efficient method for protein detection in virtue of the tremendous fluorescence enhancement property of 6-aza-2-thio-thymine protected gold nanoclusters (ATT-AuNCs).
Hao-Hua Deng, Xiao-Qiong Shi, Paramasivam Balasubramanian, Kai-Yuan Huang, Ying-Ying Xu, Zhong-Nan Huang, Hua-Ping Peng, Wei Chen   +7 more
doaj   +1 more source

Synthesis and Biological Evaluation of Marine-Inspired Benzothiazole Derivatives as Retinoid X Receptor-α Antagonists with Anti-Cancer Activities

Marine Drugs
Retinoid X receptor α (RXRα) plays a vital role in multiple biological and pathological processes and represents a promising therapeutic target for anti-tumor drug design.
Yingting Lin, Ming Peng, Renjing Yang, Guanghui Wang, Junjie Chen, Rong Ding, Cuiling Sun, Wenjing Tian, Haifeng Chen   +8 more
doaj   +1 more source

Sodium Alginate Modified Platinum Nanozymes With Highly Efficient and Robust Oxidase-Like Activity for Antioxidant Capacity and Analysis of Proanthocyanidins

Frontiers in Chemistry, 2020
Platinum nanozymes exhibiting highly efficient and robust oxidase-like activity are successfully synthesized and modified using sodium alginate (SA-PtNPs). According to a steady-state dynamic assay, Michaelis-Menton constant (Km) is calculated as 11.6 μM,
Shao-Bin He, Liu Yang, Xiu-Ling Lin, Hua-Ping Peng, Zhen Lin, Hao-Hua Deng, Wei Chen, Guo-Lin Hong   +7 more
doaj   +1 more source

Trivalent Disulfide Unit-Masked System Efficiently Delivers Large Oligonucleotide

Molecules
Oligonucleotide drugs are shining in clinical therapeutics, but efficient and safe delivery systems severely limit their widespread use. A disulfide unit technology platform based on dynamic thiol exchange chemistry at the cell membrane has the potential
Lei Wang, Xiao Liu, Yiliang Wu, Zhaoyan Ye, Yiru Wang, Shengshu Gao, Hao Gong, Yong Ling   +7 more
doaj   +1 more source

Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates

Acta Pharmaceutica Sinica B
The orphan nuclear receptor Nur77 is a critical regulator of the survival and death of tumor cells. The pro-death effect of Nur77 can be regulated by its interaction with Bcl-2, resulting in conversion of Bcl-2 from a survival to killer.
Xiaohui Chen, Meichun Gao, Yongzhen Xia, Xin Wang, Jingbo Qin, Hongying He, Weirong Liu, Xiaowei Zhang, Shuangzhou Peng, Zhiping Zeng, Ying Su, Xiaokun Zhang   +11 more
doaj   +1 more source