Results 51 to 60 of about 1,488,693 (165)

Asprosin Aggravates Tubular Epithelial Cell Injury and Phenotypic Transformation via Mitochondrial Dynamics Disorder Mediated by Excessive Drp1 SUMOylation in Diabetic Nephropathy Mice

Advanced Science
Epidemiological studies show that some diabetic patients develop end‐stage renal dysfunction without significant proteinuria or glomerulopathy, underscoring the role of renal tubular epithelial cell (TEC) impairment in diabetic kidney disease (DKD ...
Qianqian Huang, Xiaowei Xiong, Sheng Chen, Yuan Wang, Li Wang, Wentao Liu, Chen Liu, Guohua Zeng, Qiren Huang   +8 more
doaj   +1 more source

Microbiome eco-evolution of cultivated and wild rice species across the genus Oryza and its importance in supporting rice growth

Microbiome
Background Crop wild relatives and their microbiomes are essential for sustainable crop production. However, the co-evolution of wild rice species and their microbiomes remains poorly understood. Herein, we investigated microbiome assembly across 17 wild
Fei Luo, Yicong Cai, Yujie Cui, Xiangyang He, Jiawang Xu, Wanqiu Tang, Xiaoqing Wang, Yaohui Cai, Hongwei Xie, Wei Chen, Wenzhuo Li, Xia Ding   +11 more
doaj   +1 more source

Multiregional neural pathway: from movement planning to initiation

Signal Transduction and Targeted Therapy, 2022
Xing-feng Mao, Shuai-shuai Wang, Feng Han   +2 more
doaj   +1 more source

Polyzwitterion-branched polycholic acid nanocarriers based oral delivery insulin for long-term glucose and metabolic regulation in diabetes mellitus

Journal of Nanobiotechnology
Diabetes represents a global health crisis that necessitates advancements in prevention, treatment, and management. Beyond glucose regulation, addressing weight management and associated complications is imperative.
Wenkai Zhang, Yue Wang, Xiangqi Zhang, Yihui Zhang, Wei Yu, Haozheng Tang, Wei-En Yuan   +6 more
doaj   +1 more source

Novel Canthin-6-one Derivatives: Design, Synthesis, and Their Antiproliferative Activities via Inducing Apoptosis, Deoxyribonucleic Acid Damage, and Ferroptosis

ACS Omega, 2023
Jinfeng Ding, Tiantian Sun, Hongmei Wu, Hongwei Zheng, Sijia Wang, Dezhi Wang, Wenpei Shan, Yong Ling, Yanan Zhang   +8 more
doaj   +1 more source

Ancient drugs, modern targets

Cancer Biology & Therapy, 2009
Commentary to:Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cellsRamani Soundararajan, Ria Sayat, George S.
openaire   +2 more sources

NUP205 Stabilized YAP1 Protein to Stimulate Growth of Hepatocellular Carcinoma Cells in vitro and in vivo

Journal of Hepatocellular Carcinoma
Huangying Deng,1 Siqi Yu,2 Jing Zhang,2 Yuhang Hou,2 Mei Yang,2 Shengtao Yuan,2 Qiang Tu,3 Meijian Wang1 1Department of Medical Oncology, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Clinical Research ...
Deng H, Yu S, Zhang J, Hou Y, Yang M, Yuan S, Tu Q, Wang M   +7 more
doaj  

Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy

Nature Communications
Lipid nanoparticle-assisted mRNA inhalation therapy necessitates addressing challenges such as resistance to shear force damage, mucus penetration, cellular internalization, rapid lysosomal escape, and target protein expression.
Xin Bai, Qijing Chen, Fengqiao Li, Yilong Teng, Maoping Tang, Jia Huang, Xiaoyang Xu, Xue-Qing Zhang   +7 more
doaj   +1 more source

Drug-Target Interaction Prediction via Dual-Interaction Fusion. [PDF]

Molecules
Li X, Li Z, Wei B, Zeng Y.
europepmc   +1 more source

DPAGT1-Perspective as an Anticancer Drug Target. [PDF]

Molecules
Kurosu M, Mitachi K.
europepmc   +1 more source