Results 131 to 140 of about 881,158 (314)

Effect of apoA‑I PEGylation on the Biological Fate of Biomimetic High-Density Lipoproteins

ACS Omega, 2020
Dennis Pedersbæk, Louise Krogager, Camilla Hald Albertsen, Lars Ringgaard, Anders E. Hansen, Katrine Jønsson, Jannik B. Larsen, Andreas Kjær, Thomas L. Andresen, Jens B. Simonsen   +9 more
doaj   +1 more source

A microCT-based platform to quantify drug targeting. [PDF]

Eur Radiol Exp, 2023
Ausk BJ, Tucker AN, Huber P, Firoozabadi R, Gross JM, Gross TS, Bain SD.   +6 more
europepmc   +1 more source

Supplemental Figures S6 from The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs

, 2023
Michela Boi, Eugenio Gaudio, Paola Bonetti, Ivo Kwee, Elena Bernasconi, Chiara Tarantelli, Andrea Rinaldi, Monica Testoni, Luciano Cascione, Maurilio Ponzoni, Afua A. Mensah, Anastasios Stathis, Georg Stüssi, María E. Riveiro, Patrice Herait, Giorgio Inghirami, Esteban Cvitkovic, Emanuele Zucca, Francesco Bertoni   +18 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

High-density lipoprotein nanoparticles spontaneously target to damaged renal tubules and alleviate renal fibrosis by remodeling the fibrotic niches

Nature Communications
Chronic kidney disease (CKD) ultimately causes renal fibrosis and end-stage renal disease, thus seriously threatens human health. However, current medications for CKD and fibrosis are inefficient, which is often due to poor targeting capability to renal ...
Shanshan He, Xiaoyang Li, Yuanyuan He, Ling Guo, Yunzhou Dong, Leilei Wang, Lan Yang, Lin Li, Shiyun Huang, Jiali Fu, Qing Lin, Zhirong Zhang, Ling Zhang   +12 more
doaj   +1 more source

Neuronal-associated microtubule proteins class III β-tubulin and MAP2c in neuroblastoma: Role in resistance to microtubule-targeted drugs [PDF]

, 2004
Sima Don, Nicole M. Verrills, Tracy Y.E. Liaw, Marjorie L. M. Liu, Murray D. Norris, Michelle Haber, Maria Kavallaris   +6 more
openalex   +1 more source

Supplementary Figure S5 from Nonclinical Development of Next-generation Site-specific HER2-targeting Antibody–drug Conjugate (ARX788) for Breast Cancer Treatment

, 2023
Prathap Nagaraja Shastri, Jingjing Zhu, Lillian Skidmore, Xuejun Liang, Yanping Ji, Yi Gu, Feng Tian, Sulan Yao, Gang Xia   +8 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Cell surface patching via CXCR4-targeted nanothreads for cancer metastasis inhibition

Nature Communications
The binding of therapeutic antagonists to their receptors often fail to translate into adequate manipulation of downstream pathways. To fix this ‘bug’, here we report a strategy that stitches cell surface ‘patches’ to promote receptor clustering, thereby
Minglu Zhou, Chendong Liu, Bo Li, Junlin Li, Ping Zhang, Yuan Huang, Lian Li   +6 more
doaj   +1 more source

AI-powered integration of multi-source data for TAA discovery to accelerate ADC and TCE drug development (I): TAA Target Identification and Prioritization [PDF]

Tao Xie, Chao‐Hui Huang
openalex   +1 more source