Results 141 to 150 of about 3,331,587 (315)
A potential strategy to treat liver fibrosis: Drug targeting to hepatic stellate cells applying a novel linker technology [PDF]
, 2006 Liver fibrosis is the 9th leading cause of death in the world. This chronic disease cannot be treated successfully with conventional antifibrotic and anti-inflammatory drugs currently on the market, because they either lack efficacy or cause too many ...
Gonzalo Lázaro, Teresa +1 more
core +13 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Monoclonal antibody aggregates: physicochemical characteristics, stability in biological fluids and immunogenicity [PDF]
, 2012 Therapeutic proteins have become invaluable in treating a wide range of serious and life-threatening diseases. However, repeated administration of these drugs to patients often induces the formation of undesirable anti-drug antibodies, also known as ...
Pharmaceutics +3 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Effect of apoA‑I PEGylation on the Biological Fate of Biomimetic High-Density Lipoproteins
ACS Omega, 2020 Dennis Pedersbæk +9 more
doaj +1 more source
Synthetic scaffolds based on biodegradable, functionalized polyesters for tissue engineering applications [PDF]
, 2012 The aim of this thesis was to investigate the possibility of using a novel hydroxyl-functionalized polyester [poly(hydroxymethylglycolide-co-ε-caprolactone), pHMGCL] (Fig.9) to fabricate scaffolds for tissue engineering applications.
Pharmaceutics +2 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
A microCT-based platform to quantify drug targeting. [PDF]
Eur Radiol Exp, 2023 Ausk BJ +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
, 1997 Pharmacotherapy through the targeting of drugs is a promising new approach that requires adequate analytical methods capable of differentiating between the free drug the drug carrier, and metabolites.
Visser, Jan +4 more
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