Results 161 to 170 of about 3,331,587 (315)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Safety and Pharmacokinetics of SRN001, a Novel siRNA Drug Targeting Amphiregulin via the SAMiRNA Platform. [PDF]

Drug Des Devel Ther
Park J, Lee S, Chung JY, Yun S, Park HO, Park JY, Jang I.   +6 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Age-dependent efficiency of magnetic drug targeting in young and old patient-specific aortic models. [PDF]

Sci Rep
Hosseini SB, Almosawy W, Takrami RK, Abdi N, Aminian S.   +4 more
europepmc   +1 more source

Editorial: RNA recognition landscapes and anticancer drug targeting. [PDF]

Front Oncol, 2023
Salvati E, Lewinska A, Dassi E, Wnuk M, D'Agostino VG.   +4 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Nucleolar organization and divergent transcriptional machinery in Giardia lamblia: Structural insights and implications for drug targeting. [PDF]

Parasites Hosts Dis
Gaona-López C.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Pathophysiological and pharmacological implications of elucidating the molecular bases of the interaction between HBV and the bile acid transporter NTCP

Annals of Hepatology, 2015
Marta R. Romero, Maria J. Monte, Jose J.G. Marin, Ph.D.   +2 more
doaj   +1 more source

Single-cell transcriptomic mapping of patient-derived primary liver cancer organoids reveals molecular subtypes and guides precision drug targeting. [PDF]

Cell Oncol (Dordr)
Dai S, Wu J, Chai Y, Li Z, Xie Y, Wang H, Liu Z, He Y, Cao H, Tang W, Xu J, Zhang Z, Xia Y, Wang X, Liu L, Xia X, Gao Y.   +16 more
europepmc   +1 more source