Results 161 to 170 of about 1,512,902 (358)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A microCT-based platform to quantify drug targeting. [PDF]

Eur Radiol Exp, 2023
Ausk BJ, Tucker AN, Huber P, Firoozabadi R, Gross JM, Gross TS, Bain SD.   +6 more
europepmc   +1 more source

Current Status of Drug Targets and Emerging Therapeutic Strategies in the Management of Alzheimer's Disease

, 2020
Shampa Ghosh, Shantanu Durgvanshi, Shreya Agarwal, Manchala Raghunath, Jitendra Kumar Sinha   +4 more
openalex   +2 more sources

Reducing Toxicity of Immune Therapy Using Aptamer-Targeted Drug Delivery [PDF]

, 2015
Eli Gilboa, Alexey Berezhnoy, Brett Schrand   +2 more
openalex   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Effect of apoA‑I PEGylation on the Biological Fate of Biomimetic High-Density Lipoproteins

ACS Omega, 2020
Dennis Pedersbæk, Louise Krogager, Camilla Hald Albertsen, Lars Ringgaard, Anders E. Hansen, Katrine Jønsson, Jannik B. Larsen, Andreas Kjær, Thomas L. Andresen, Jens B. Simonsen   +9 more
doaj   +1 more source

Cell surface patching via CXCR4-targeted nanothreads for cancer metastasis inhibition

Nature Communications
The binding of therapeutic antagonists to their receptors often fail to translate into adequate manipulation of downstream pathways. To fix this ‘bug’, here we report a strategy that stitches cell surface ‘patches’ to promote receptor clustering, thereby
Minglu Zhou, Chendong Liu, Bo Li, Junlin Li, Ping Zhang, Yuan Huang, Lian Li   +6 more
doaj   +1 more source

Drug initiation and escalation strategies of vasodilator therapies for Raynaud’s phenomenon: can we treat to target? [PDF]

, 2019
Michael Hughes, Dinesh Khanna, John D Pauling   +2 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

High-density lipoprotein nanoparticles spontaneously target to damaged renal tubules and alleviate renal fibrosis by remodeling the fibrotic niches

Nature Communications
Chronic kidney disease (CKD) ultimately causes renal fibrosis and end-stage renal disease, thus seriously threatens human health. However, current medications for CKD and fibrosis are inefficient, which is often due to poor targeting capability to renal ...
Shanshan He, Xiaoyang Li, Yuanyuan He, Ling Guo, Yunzhou Dong, Leilei Wang, Lan Yang, Lin Li, Shiyun Huang, Jiali Fu, Qing Lin, Zhirong Zhang, Ling Zhang   +12 more
doaj   +1 more source