Results 251 to 260 of about 3,331,587 (315)

SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites. [PDF]

Acta Pharm Sin B
Zhu K, Song L, Wang L, Hua L, Luo Z, Wang T, Qin B, Yuan S, Gao X, Mi W, Cui S.   +10 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Tezepelumab for Severe Asthma: One Drug Targeting Multiple Disease Pathways and Patient Types. [PDF]

J Asthma Allergy
Panettieri R, Lugogo N, Corren J, Ambrose CS.   +3 more
europepmc   +1 more source

Cure of experimental Trypanosoma vivax infection with a single dose of an unmodified antibody-based drug targeting the invariant flagellum cell surface protein IFX

Autheman D, Viola C, Rhodes G, Clare S, Brandt C, Harcourt K, Wright GJ.   +6 more
europepmc   +1 more source

Refining breast cancer biomarker discovery and drug targeting through an advanced data-driven approach. [PDF]

BMC Bioinformatics
Rakhshaninejad M, Fathian M, Shirkoohi R, Barzinpour F, Gandomi AH.   +4 more
europepmc   +1 more source

Drug targeting

European Journal of Pharmaceutical Sciences, 2000
The main problems currently associated with systemic drug administration are: even biodistribution of pharmaceuticals throughout the body; the lack of drug specific affinity toward a pathological site; the necessity of a large total dose of a drug to achieve high local concentration; non-specific toxicity and other adverse side-effects due to high drug
Vladimir Torchilin
exaly   +6 more sources

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Drug Targeting to the Brain

Annual Review of Pharmacology and Toxicology, 2007
The central nervous system (CNS) is a sanctuary site and is protected by various barriers. These regulate brain homeostasis and the transport of endogenous and exogenous compounds by controlling their selective and specific uptake, efflux, and metabolism in the brain. Unfortunately, potential drugs for the treatment of most brain diseases are therefore
A G de Boer, P J Gaillard
exaly   +5 more sources

Drugs, their targets and the nature and number of drug targets

Nature Reviews Drug Discovery, 2006
What is a drug target? And how many such targets are there? Here, we consider the nature of drug targets, and by classifying known drug substances on the basis of the discussed principles we provide an estimation of the total number of current drug targets.
Peter, Imming, Christian, Sinning, Achim, Meyer   +2 more
openaire   +2 more sources

Proteasomes as Drug Targets

Current Drug Targets, 2003
The ubiquitin-proteasome pathway plays a role in the degradation of the bulk of proteins in the cytoplasmic and nuclear compartments. In this pathway proteins are targeted for degradation by covalent ligation with ubiquitin, a reaction that requires ATP.
PICCININI, Marco, MOSTERT, Michael Martin, RINAUDO, Maria Teresa   +2 more
openaire   +3 more sources

Colonic Drug Targeting

Journal of Drug Targeting, 1998
Specific targeting of drugs to the colon is recognized to have several therapeutic advantages. Drugs which are destroyed by the stomach acid and/or metabolized by pancreatic enzymes are slightly affected in the colon, and sustained colonic release of drugs can be useful in the treatment of nocturnal asthma, angina and arthritis.
R, Kinget, W, Kalala, L, Vervoort, G, van den Mooter   +3 more
openaire   +2 more sources