Results 261 to 270 of about 3,331,587 (315)
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Journal of Cellular Biochemistry, 2010
AbstractMitosis is the key event of the cell cycle during which the sister chromatids are segregated onto two daughter cells. It is well established that abrogation of the normal mitotic progression is a highly efficient concept for anti‐cancer treatment.
Phillip, Kaestner, Holger, Bastians
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AbstractMitosis is the key event of the cell cycle during which the sister chromatids are segregated onto two daughter cells. It is well established that abrogation of the normal mitotic progression is a highly efficient concept for anti‐cancer treatment.
Phillip, Kaestner, Holger, Bastians
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Nature, 1977
Recent work suggests that specific association of drugs with their targets could be achieved by means of a versatile carrier capable of transporting drug molecules from the site of application directly to the site of action.
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Recent work suggests that specific association of drugs with their targets could be achieved by means of a versatile carrier capable of transporting drug molecules from the site of application directly to the site of action.
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Cancer, 1986
Cancer chemotherapy drugs are neither specific, i.e., they do not act exclusively on the metabolic pathways of cancer cells, nor are they targeted solely toward cancer cells. However, recent research has begun to address, in part, the latter issue. Improved delivery of chemotherapeutic agents to tumor tissue in man appears to be an achievable goal in ...
A I, Freeman, E, Mayhew
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Cancer chemotherapy drugs are neither specific, i.e., they do not act exclusively on the metabolic pathways of cancer cells, nor are they targeted solely toward cancer cells. However, recent research has begun to address, in part, the latter issue. Improved delivery of chemotherapeutic agents to tumor tissue in man appears to be an achievable goal in ...
A I, Freeman, E, Mayhew
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Drug Targets, Drug Effectors, and Drug Targeting and Delivery
2012The chemotherapy of leishmaniases has undergone significant improvements during the last decade with the use of liposomal amphotericin B formulation (AmBisome®) and miltefosine as the first orally active drug. However, whatever the proposed treatment, limitations such as adverse effects and the emergence of drug resistance justify the search for new ...
Philippe M. Loiseau, Gillian Barratt
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Critical Care Medicine, 2003
To review the preclinical and clinical evidence that antiendotoxin therapeutic strategies are potentially useful in the prevention and treatment of septic shock.A critical review of the literature over the past 30 yrs relating basic and clinical research on the therapeutic value of endotoxin as a target for the prevention and treatment of severe sepsis
Steven M, Opal, Thomas, Glück
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To review the preclinical and clinical evidence that antiendotoxin therapeutic strategies are potentially useful in the prevention and treatment of septic shock.A critical review of the literature over the past 30 yrs relating basic and clinical research on the therapeutic value of endotoxin as a target for the prevention and treatment of severe sepsis
Steven M, Opal, Thomas, Glück
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Biochemical Society Transactions, 2010
The amyloid hypothesis indicates that protein misfolding is at the root of many neurodegenerative disorders. Small molecules targeting the formation, clearance, aggregation to toxic oligomers or SOD (superoxide dismutase)-like activities of Aβ (amyloid β-peptide) 1–42 have provided encouraging candidates for AD (Alzheimer's disease) medicines in animal
Kolstoe, Simon, Wood, S.
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The amyloid hypothesis indicates that protein misfolding is at the root of many neurodegenerative disorders. Small molecules targeting the formation, clearance, aggregation to toxic oligomers or SOD (superoxide dismutase)-like activities of Aβ (amyloid β-peptide) 1–42 have provided encouraging candidates for AD (Alzheimer's disease) medicines in animal
Kolstoe, Simon, Wood, S.
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Nature Biotechnology, 2007
The global set of relationships between protein targets of all drugs and all disease-gene products in the human protein-protein interaction or 'interactome' network remains uncharacterized. We built a bipartite graph composed of US Food and Drug Administration-approved drugs and proteins linked by drug-target binary associations.
Muhammed A, Yildirim +4 more
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The global set of relationships between protein targets of all drugs and all disease-gene products in the human protein-protein interaction or 'interactome' network remains uncharacterized. We built a bipartite graph composed of US Food and Drug Administration-approved drugs and proteins linked by drug-target binary associations.
Muhammed A, Yildirim +4 more
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Current Oncology Reports, 2010
Heat shock protein 90 (Hsp90) is a molecular chaperone involved in the trafficking of proteins in the cell. Under stressful conditions, Hsp90 stabilizes its client proteins and provides protection to the cell against cellular stressors such as in cancer cells. Disruption of Hsp90 leads to client protein degradation and often cell death.
Jeffrey M, Holzbeierlein +2 more
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Heat shock protein 90 (Hsp90) is a molecular chaperone involved in the trafficking of proteins in the cell. Under stressful conditions, Hsp90 stabilizes its client proteins and provides protection to the cell against cellular stressors such as in cancer cells. Disruption of Hsp90 leads to client protein degradation and often cell death.
Jeffrey M, Holzbeierlein +2 more
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The Hydrogenosome as a Drug Target
Current Pharmaceutical Design, 2008Hydrogenosomes are spherical or slightly elongated organelles found in non-mitochondrial organisms. In Trichomonas hydrogenosomes measure between 200 to 500 nm, but under drug treatment they can reach 2 microm. Like mitochondria hydrogenosomes: (1) are surrounded by two closely apposed membranes and present a granular matrix: (2) divide in three ...
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Expert Opinion on Therapeutic Targets, 2005
The process of ageing denotes a postmaturational deterioration of cells and organisms with the passage of time, an increased vulnerability to challenges and a decreased ability to survive. Causes may be found in oxidative damage and incomplete cell maintenance, and both of these factors may be considered the primary targets of any antiageing therapy ...
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The process of ageing denotes a postmaturational deterioration of cells and organisms with the passage of time, an increased vulnerability to challenges and a decreased ability to survive. Causes may be found in oxidative damage and incomplete cell maintenance, and both of these factors may be considered the primary targets of any antiageing therapy ...
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