Results 281 to 290 of about 3,331,587 (315)
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Biochemical Society Symposia, 2003
The effective management of AIDS with HIV protease inhibitors, or the use of angiotensin-converting enzyme inhibitors to treat hypertension, indicates that proteases do make good drug targets. On the other hand, matrix metalloproteinase (MMP) inhibitors from several companies have failed in both cancer and rheumatoid arthritis clinical trials.
Andy J, Docherty +3 more
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The effective management of AIDS with HIV protease inhibitors, or the use of angiotensin-converting enzyme inhibitors to treat hypertension, indicates that proteases do make good drug targets. On the other hand, matrix metalloproteinase (MMP) inhibitors from several companies have failed in both cancer and rheumatoid arthritis clinical trials.
Andy J, Docherty +3 more
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Current Protocols in Pharmacology, 2006
AbstractReceptors, located on both the cell surface and within the cell, are the molecular targets through which drugs produce their beneficial effects in various disease states. Receptors were initially conceptualized at the beginning of the 20th century by the parallel efforts of Ehrlich and Langley.
Michael, Williams, Rita, Raddatz
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AbstractReceptors, located on both the cell surface and within the cell, are the molecular targets through which drugs produce their beneficial effects in various disease states. Receptors were initially conceptualized at the beginning of the 20th century by the parallel efforts of Ehrlich and Langley.
Michael, Williams, Rita, Raddatz
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Current Opinion in Structural Biology, 2005
Several classes of clinically important antibiotics target the bacterial ribosome, where they interfere with microbial protein synthesis. Structural studies of the interaction of antibiotics with the ribosome have revealed that these small molecules recognize predominantly the rRNA components.
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Several classes of clinically important antibiotics target the bacterial ribosome, where they interfere with microbial protein synthesis. Structural studies of the interaction of antibiotics with the ribosome have revealed that these small molecules recognize predominantly the rRNA components.
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Clinical Radiology, 1985
'Now, if we were to succeed in discovering amongst these (chemoceptors) a receptor which was not represented in the organs of the host, we would have the possibility of constructing an ideal medicament by selecting a haptophore group that fits exclusively this particular receptor of the parasite. A medicament provided with such a haptophore group would
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'Now, if we were to succeed in discovering amongst these (chemoceptors) a receptor which was not represented in the organs of the host, we would have the possibility of constructing an ideal medicament by selecting a haptophore group that fits exclusively this particular receptor of the parasite. A medicament provided with such a haptophore group would
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Trends in Biotechnology, 2006
The elucidation of the crystal structure of the ribosome and its subunits has dramatically increased our understanding of this organelle and the molecular interactions that determine its functional capabilities. Two recent publications, one on the structure of the bacterial ribosome at 3.5A resolution and one on the identification of functionally ...
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The elucidation of the crystal structure of the ribosome and its subunits has dramatically increased our understanding of this organelle and the molecular interactions that determine its functional capabilities. Two recent publications, one on the structure of the bacterial ribosome at 3.5A resolution and one on the identification of functionally ...
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Annual Review of Pharmacology and Toxicology, 2000
This article considers early work from the author’s laboratory on muscarinic receptor specificity, subtypes, and conformational variability, with the use of nuclear magnetic resonance in pharmacology and the conformational variants of dihydrofolate reductase and general questions of receptors.
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This article considers early work from the author’s laboratory on muscarinic receptor specificity, subtypes, and conformational variability, with the use of nuclear magnetic resonance in pharmacology and the conformational variants of dihydrofolate reductase and general questions of receptors.
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1996
Publisher Summary Antioxidants have been known to prevent lipid peroxidation, the depletion of reduced glutathione and other intracellular protectants against oxidation, and lipoprotein oxidation. Antioxidants help the regulation of signal transduction, kinase and phosphatase activation, gene expression, and enzyme activation.
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Publisher Summary Antioxidants have been known to prevent lipid peroxidation, the depletion of reduced glutathione and other intracellular protectants against oxidation, and lipoprotein oxidation. Antioxidants help the regulation of signal transduction, kinase and phosphatase activation, gene expression, and enzyme activation.
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Recent advances in active targeting of nanomaterials for anticancer drug delivery
Advances in Colloid and Interface Science, 2021Puthusserickal Hassan +2 more
exaly