Results 281 to 290 of about 1,512,902 (358)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

SYNERGIZING LIPID-BASED NANOPARTICLES, MICROROBOTICS, AND PLANT-DERIVED AGENTS FOR PRECISION DRUG TARGETING

Sengar Ashutosh*1, Priyanka Maheshkumar Kushwaha2
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Cure of experimental Trypanosoma vivax infection with a single dose of an unmodified antibody-based drug targeting the invariant flagellum cell surface protein IFX

Autheman D, Viola C, Rhodes G, Clare S, Brandt C, Harcourt K, Wright GJ.   +6 more
europepmc   +1 more source

SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites. [PDF]

Acta Pharm Sin B
Zhu K, Song L, Wang L, Hua L, Luo Z, Wang T, Qin B, Yuan S, Gao X, Mi W, Cui S.   +10 more
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Baicalein Ameliorates Experimental Ulcerative Colitis Recurrency by Downregulating Neonatal Fc Receptor via the NF-κB Signaling Pathway

ACS Omega
Haoyang Hu, Fuliang Lu, Xudong Guan, Xuehua Jiang, Chengming Wen, Ling Wang   +5 more
doaj   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Tezepelumab for Severe Asthma: One Drug Targeting Multiple Disease Pathways and Patient Types. [PDF]

J Asthma Allergy
Panettieri R, Lugogo N, Corren J, Ambrose CS.   +3 more
europepmc   +1 more source

DRUG TARGET IDENTIFICATION BY USING ARTIFICIAL INTELLIGENCE

Dr. Y. Anil Kumar*1, B. Kalyani2, D. Arshiya3, S. K. Sony Begum4, T. Komali5, Karan Dhungana6, Laishram Jaichandra Singh7
openalex   +1 more source