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Fixed Combination Drug Therapy
Drugs, 1982Almost half of all marketed drugs are fixed combination preparations, yet the World Health Organization included only 7 in its list of 240 "essential' drugs. There has been little scientific study of these preparations but much emotion and rhetoric has been expended both for and against them.
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Combination drug therapy for dyslipidaemia
Current Opinion in Lipidology, 1993The use of combination therapy with lipid-lowering agents which have complementary effects on lipoprotein metabolism is an important option for the treatment of severe hyperlipoproteinaemia. This review presents a discussion of recent studies of combination therapy set against the background of existing knowledge in this important therapeutic area.
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Combined drug therapy of hypertension
1960Since current drug treatment of hypertension is primarily suppressive rather than curative, the prolonged maintenance of blood pressure reduction is as important as the ability to cause an early and marked depression of the blood pressure by acute treatment.
S. W. Hoobler, P. Lauwers
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Combination Drug Therapy in the Elderly
2007Awareness, treatment, and control of hypertension in the United States have been improving for geriatric patients (1). However, awareness, treatment, and control remain the lowest among the oldest age group (2). This is ironic given the fact that the largest body of outcomes trials documents the reduction of morbidity and mortality in the elderly ...
L. Michael Prisant, Laura L. Mulloy
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Drug combination therapy of systemic lupus erythematosus
Springer Seminars in Immunopathology, 1994During the past few decades, the survival of systemic lupus erythematosus (SLE) patients has steadily improved, so much so that it has become a minor issue with a mortality rate of approximately 1-2% per annum [2, 11]. The main problem today for lupus patients concerns their quality of life and the risk of loss of kidney function.
Robert Lemoine +3 more
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Problems of Combination Drug Therapy in Children
Epilepsia, 1988Summary: Despite the current trend toward monotherapy, polytherapy in children with epilepsy is still common. A drug combination is advantageous only if it achieves a higher efficacy: toxicity ratio (therapeutic index) or if its antiepileptic spectrum is wider.
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Drug Combinations as Rational Antihypertensive Therapy
Archives of Internal Medicine, 1974The goal of antihypertensive therapy is to restore blood pressure to normal with as few side effects as possible. Usually this is best accomplished by skillfully combining two or more drugs in the regimen. A diuretic should be the cornerstone on which the regimen is built; for many patients with mild hypertension, a diuretic will be the only drug ...
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Combination Drug Therapy for Gastroesophageal Reflux Disease
The Annals of Pharmacotherapy, 2002OBJECTIVE: To evaluate the role of combination therapy with proton-pump inhibitors (PPIs) and histamine2 receptor antagonists in gastroesophageal reflux disease (GERD). DATA SOURCES: Clinical literature identified through MEDLINE (January 1966–August 2001).
Lori N Justice, L Brian Cross
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Drug–drug interactions and tolerance in combining antituberculosis and antiretroviral therapy
Expert Opinion on Drug Safety, 2005Worldwide, tuberculosis (TB) is one of the most important infectious diseases in subjects with HIV infection. Although effective therapy is available for both conditions, there are major problems in the concurrent treatment of HIV and TB co-infection.
DI PERRI, Giovanni +6 more
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Combination Drug Therapy versus Single Drug Therapy [PDF]
2nd Annual International Conference on Pharmacology and Pharmaceutical Sciences (PHARMA 2014), 2014 P. N. Amaranath, Zaheda Bano, Sk. Farida
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