Results 231 to 240 of about 2,849,098 (354)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Multidimensional tumor heterogeneity and its role in therapeutic resistance. [PDF]

Front Immunol
Mubin N, Alnukhali M, Ahmad N, Driscoll JJ, Ahmad A.   +4 more
europepmc   +1 more source

Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia.

New England Journal of Medicine, 2001
S. Deeks, T. Wrin, T. Liegler, R. Hoh, M. Hayden, J. Barbour, N. Hellmann, C. Petropoulos, J. McCune, M. Hellerstein, R. Grant   +10 more
semanticscholar   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Editorial: Innovative drug combinations for enhanced solid tumor treatment efficacy

Frontiers in Oncology
Giovanna Damia, Massimo Broggini
doaj   +1 more source

Molecular targeting of the meningioma cell signaling circuit reveals drug vulnerabilities including synergy between sulforaphane and focal adhesion kinase inhibition. [PDF]

BJC Rep
Schwab MC, Kocas Y, Gendreizig S, Goulin Lippi Fernandes E, Ersoy TF, Coras R, Scholtz LU, Sudhoff H, Todt I, Simon M, Schürmann M, Oppel F.   +11 more
europepmc   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Eravacycline monotherapy and combination therapy against KPC-2- and NDM-1-co- producing <i>Klebsiella pneumoniae</i>: <i>in vitro</i> and <i>in vivo</i> activity analysis. [PDF]

Front Microbiol
Zhao X, Wang J, Deng X, Shi M, Song S, Zhao S, Sun J, Ma Y, Zhu W, Jiang F, Tong J, Kang H.   +11 more
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Treatment sequence patterns of urate-lowering therapy in Korean patients with gout: A common data model-based study. [PDF]

PLoS One
Kim MJ, Park EG, Kim C, Kang DY, Ryu B, Shin K.   +5 more
europepmc   +1 more source