Results 101 to 110 of about 10,148,101 (391)

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

FEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos, Doriana Ricciuti, Giada Mondanelli, Marco Gargaro   +3 more
wiley   +1 more source

Efficacy of various extent of resection on survival rates of patients with pilocytic astrocytoma: based on a large population

Scientific Reports
Pilocytic astrocytoma (PA) is classified as a Grade I benign neuroglial tumor. The extent of surgical resection is a critical factor influencing the prognosis for patients with PA.
Jun Su, Shanshan Guo, Zheyuan Chen, Yiming Han, Jingwang Yan, Qiyun Tang, Yu Mao, Haiqiang Zhang, Guojiang Hou, Gaopan Dong, Chao Guo, Pengfei Yang   +11 more
doaj   +1 more source

NIR/pH-triggered aptamer-functionalized DNA origami nanovehicle for imaging-guided chemo-phototherapy

Journal of Nanobiotechnology, 2023
Targeted chemo-phototherapy has received widespread attention in cancer treatment for its advantages in reducing the side effects of chemotherapeutics and improving therapeutic effects.
Mengyue Li, Geng Yang, Yue Zheng, Jiazhen Lv, Wanyi Zhou, Hanxi Zhang, Fengming You, Chunhui Wu, Hong Yang, Yiyao Liu   +9 more
doaj   +1 more source

DRUG THERAPY IN PYELITIS [PDF]

JAMA: The Journal of the American Medical Association, 1922
The present study is concerned with an attempt to determine the direct mode of action of several of the more commonly used drugs in the treatment of pyelitis. The action of the alkalis, of hexamethylenamin and of phenyl salicylate has been studied. First, it must be said that pyelitis, in most instances, is a self limited disease, which may disappear ...
openaire   +3 more sources

The DiSC assay - A cost-effective guide to treatment for chronic lymphocytic leukemia? [PDF]

, 1999
The differential staining cytotoxicity (DISC) assay involves in vitro drug panel testing against patient tumor cells to identify optimal therapy. This observational study investigated whether DISC assay guided treatment could improve outcome in patients ...
Bosanquet, A.G., Drummond, M.F., Mason, J.M., Sheldon, T.A.   +3 more
core   +1 more source

Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

Signal Transduction and Targeted Therapy, 2019
The application of nanomedicines is increasing rapidly with the promise of targeted and efficient drug delivery. Nanomedicines address the shortcomings of conventional therapy, as evidenced by several preclinical and clinical investigations indicating ...
A. Singh, Arpan Biswas, A. Shukla, P. Maiti   +3 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

The role of transcriptional regulators in metal ion homeostasis of Mycobacterium tuberculosis

Frontiers in Cellular and Infection Microbiology
Metal ions are essential trace elements for all living organisms and play critical catalytic, structural, and allosteric roles in many enzymes and transcription factors.
Shuxian Wang, Ren Fang, Hui Wang, Xiaotian Li, Jiayin Xing, Zhaoli Li, Ningning Song   +6 more
doaj   +1 more source

Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro

Molecules, 2020
Alzheimer’s disease (AD) and Parkinson’s disease (PD), including dementia with Lewy bodies (DLB), account for the majority of dementia cases worldwide.
Janett Köppen, Anja Schulze, Lisa Machner, Michael Wermann, Rico Eichentopf, Max Guthardt, Angelika Hähnel, Jessica Klehm, Marie-Christin Kriegeskorte, Maike Hartlage-Rübsamen, Markus Morawski, Stephan von Hörsten, Hans-Ulrich Demuth, Steffen Roßner, Stephan Schilling   +14 more
doaj   +1 more source

Music therapy, neural processing, and craving reduction: an RCT protocol for a mixed methods feasibility study in a Community Substance Misuse Treatment Service

Addiction Science & Clinical Practice, 2023
Background Music therapy has been shown to be effective for multiple clinical endpoints associated with substance use disorder such as craving reduction, emotion regulation, depression, and anxiety, but there are a lack of studies investigating those ...
Jörg Fachner, Clemens Maidhof, Daniel Murtagh, Devon De Silva, Filippo Pasqualitto, Paul Fernie, Francesca Panin, Andrew Michell, Leonardo Muller-Rodriguez, Helen Odell-Miller   +9 more
doaj   +1 more source