Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import
Retrovirology, 2018 Background Combination antiretroviral therapy efficiently suppresses HIV replication in infected patients, transforming HIV/AIDS into a chronic disease. Viral resistance does develop however, especially under suboptimal treatment conditions such as poor ...
Jonas Demeulemeester +8 more
doaj +1 more source
Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents.
New England Journal of Medicine, 2014 BACKGROUND Dual antiplatelet therapy is recommended after coronary stenting to prevent thrombotic complications, yet the benefits and risks of treatment beyond 1 year are uncertain.
L. Mauri +23 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Frontiers in MicrobiologyTick-borne diseases are a growing public health concern in the United States, with cases rising steadily each year. Lyme borreliosis, or Lyme disease, remains the most prevalent, affecting approximately 476,000 individuals annually.
Aaron Scholl +3 more
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Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. [PDF]
, 2007 BackgroundWe reported previously on the emergence and clinical implications of simian immunodeficiency virus (SIVmac251) mutants with a K65R mutation in reverse transcriptase (RT), and the role of CD8+ cell-mediated immune responses in suppressing ...
Bischofberger, Norbert +10 more
core +3 more sources
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
The effect of anticholinergic drugs on the cardiac vagus: II, the cardiovascular response of animals to electroconvulsive therapy [PDF]
, 1959 Allen B. Dobkin, Jurek Olszewski
openalex +1 more source
Effectiveness of blood pressure control in a small community [PDF]
, 1989 The aim of this study was to examine the degree of control of blood pressure with respect to individuals on anti-hypertensive drug therapy attending a Health Centre for repeat prescription.
Cacciottolo, Joseph M., Galea, Wilfred
core
Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy [PDF]
, 2015 The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy.
Bahrami, B. +8 more
core +1 more source
Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy
Molecules, 2017 Dendrimers are highly branched polymers with easily modifiable surfaces. This makes them promising structures for functionalization and also for conjugation with drugs and DNA/RNA.
Livia Palmerston Mendes +2 more
semanticscholar +1 more source