Weight gain as a cause of ineffective drug therapy and failed subcutaneous defibrillator shocks in a paediatric patient with Jervell and Lange-Nielsen syndrome: a case report. [PDF]
Eur Heart J Case RepAdamuz IA +4 more
europepmc +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Comparing bridging drug therapy approaches prior to balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: a prospective analysis from the national UK CURATE registry. [PDF]
Open HeartLi OM +12 more
europepmc +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
ERRATUM: Current evidence on drug therapy for dementia in people with Down syndrome: an overview of systematic reviews. [PDF]
Dement Neuropsycholeuropepmc +1 more source
Protocol for DESCIDE-RD: Determining Effectiveness of Shared Decision Making in Drug Therapy Selection for Rheumatic Diseases. [PDF]
J Korean Med SciChoi SR +11 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Factors associated with occurrence of drug therapy problems among patients with neoplasms of s-sectional studydigestive organs at Uganda Cancer Institute, Mbarara: a cros. [PDF]
BMC CancerOjuka S +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Mixed-Methods Study With a Systematic Review of Personalized Drug Therapy Approaches and Survey Analysis of Pharmacogenomics in Internal Medicine. [PDF]
CureusElachola MS +7 more
europepmc +1 more source