Results 181 to 190 of about 1,680,438 (318)

Research Trends in Chronic Obstructive Pulmonary Disease (2005-2024): From Drug Therapy to Comprehensive Rehabilitation Strategies. [PDF]

Int J Chron Obstruct Pulmon Dis
Zhan M, Chen J, Zhang H.
europepmc   +1 more source

Use of the Novel Site-Directed Enzyme Enhancement Therapy (SEE-Tx) Drug Discovery Platform to Identify Pharmacological Chaperones for Glutaric Acidemia Type 1

Madalena Barroso, Alexandra Puchwein-Schwepcke, Lars Buettner, Ingrid Goebel, Karl Kuchler, Ania C. Muntau, Aida Delgado, Ana María García-Collazo, Marc Martinell, Xavier Barril, Elena Cubero, Søren W. Gersting   +11 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Pituitary apoplexy causing spontaneous remission of acromegaly following long-acting octreotide therapy: a rare drug side effect or just a coincidence [PDF]

, 2016
Sunil Kumar, Shruti Sharma
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

A Structured Approach to Identifying and Addressing Drug Therapy Problems in Neonatal and Pediatric Critically Ill Patients: IN-DEPTH. [PDF]

J Pediatr Pharmacol Ther
Moore B, Johnson PN, Miller J.
europepmc   +1 more source

Canagliflozin as an Initial Therapy in Drug-Naïve Subjects with Type 2 Diabetes Mellitus: A Potential Involvement of Atherogenic Lipids in its Glycemic Efficacy [PDF]

, 2017
Eiji Kutoh, Asuka Wada, Teruma Murayama, Yui Takizawa   +3 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dementia and Sleep Disorders: The Effects of Drug Therapy in a Systematic Review. [PDF]

Int J Mol Sci
Chavez-Mendoza LF, Vázquez-Alvarez AO, Torres-Mendoza BM, Trujillo-Rangel WA, Torres-Sánchez ED, Bracho-Valdés I, Delgado-Lara DLC.   +6 more
europepmc   +1 more source

Use of a Bioinformatics‐Based Toxicity Scoring System to Assess Serotonin Burden and Predict Population‐Level Adverse Drug Events from Concomitant Serotonergic Drug Therapy

, 2019
Vaughn L. Culbertson, Shaikh Emdadur Rahman, Grayson C. Bosen, Matthew L. Caylor, Dong Xu   +4 more
openalex   +2 more sources