Results 191 to 200 of about 1,839,583 (268)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Effects of ablation versus drug therapy on clinical outcomes and quality of life by frailty status in atrial fibrillation: a post hoc analysis of the CABANA trial. [PDF]

BMC Med
Wang L, Li Y, Li Q, Liu X, Weng S, Yin Y, Wu Q, Liu Y, Hu Z, Gao H, Xiong R, Liang Z, Zhang T, Quan X, Wang Y.   +14 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Is the effect of antihypertensive drug therapy on blood pressure control and prevalent cardiovascular disease associated with dietary sodium-potassium ratio? A cross-sectional study based on NHANES. [PDF]

Front Cardiovasc Med
Zhang O, Wang Y, Geng Y, Bi L, Shi B, Zhao Y, Wu X.   +6 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

A Structured Approach to Identifying and Addressing Drug Therapy Problems in Neonatal and Pediatric Critically Ill Patients: IN-DEPTH. [PDF]

J Pediatr Pharmacol Ther
Moore B, Johnson PN, Miller J.
europepmc   +1 more source

Research Trends in Chronic Obstructive Pulmonary Disease (2005-2024): From Drug Therapy to Comprehensive Rehabilitation Strategies. [PDF]

Int J Chron Obstruct Pulmon Dis
Zhan M, Chen J, Zhang H.
europepmc   +1 more source

Impact of Anti-Inflammatory Drug Therapy on the Efficacy of First-Line Atezolizumab Treatment in Patients With Advanced Non-Small Cell Lung Cancer: An Integrated Analysis of Five Randomized Controlled Trials. [PDF]

Thorac Cancer
Takada K, Cortellini A, Takamori S, Mizuki F, Pinato DJ, Shimokawa M.   +5 more
europepmc   +1 more source