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Drug-induced Immunological Tolerance
Nature, 1959PREVIOUS work in this laboratory demonstrated that administration of a purine analogue, 6-mercaptopurine, suppressed the antibody response to a soluble antigen (human serum albumin) in rabbits1. It was shown that the antimetabolite could block completely the primary immune response to the purified protein antigen; its effect on the secondary response ...
R, SCHWARTZ, W, DAMESHEK
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Tolerance and cross-tolerance among psychotomimetic drugs
Psychopharmacologia, 1968A fixed-ratio schedule of milk reinforcement (FR 30) was used to study tolerance to the effects of d-LSD, l-LSD, BOL, psilocybin, mescaline, and d-amphetamine in the rat. A decrease in the amount of disruption of bar-pressing occurs with repeated daily administration of appropriate doses of all of the “psychotomimetic” compounds, and cross-tolerance ...
J B, Appel, D X, Freedman
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Safety and tolerability profile of new antiepileptic drug treatment in children with epilepsy
Expert Opinion on Drug Safety, 2018Introduction: Treatment of pediatric epilepsy requires a careful evaluation of the safety and tolerability profile of antiepileptic drugs (AEDs) to avoid or minimize as much as possible adverse events (AEs) on various organs, hematological parameters ...
R. Moavero +3 more
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Occasion setting and drug tolerance
Integrative Physiological & Behavioral Science, 2002There is considerable evidence that drug-paired cues become associated with drug effects. It has been hypothesized that these cues act as Pavlovian conditional stimuli (CSs), and elicit conditional compensatory responses that contribute to tolerance.
Barbara M C, Ramos +2 more
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Receptor alterations and drug tolerance
Life Sciences, 1979Abstract A brief review of studies which have employed chronic administration of anticholinesterases, benzodiazepines, amphetamine, antidepressants, neuroleptics and opiates is presented to illustrate the deficiencies in our current knowledge about the degree to which alterations in neurotransmitter receptors can account for tolerance development to ...
D H, Overstreet, H I, Yamamura
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