Results 281 to 290 of about 4,643,128 (344)

Pharmacokinetics, drug interactions, and tolerability of valproate.

Psychopharmacology bulletin, 2015
Valproate is a branched-chain carboxylic acid with an extensive history of use as an antiepileptic drug. In recent years, multiple uses for valproate have been found in psychiatry. As divalproex sodium, it is currently approved for the treatment of manic
Devane Cl
semanticscholar   +1 more source

Neurostimulation in people with drug‐resistant epilepsy: Systematic review and meta‐analysis from the ILAE Surgical Therapies Commission

Epilepsia, 2022
Summarize the current evidence on efficacy and tolerability of vagus nerve stimulation (VNS), responsive neurostimulation (RNS), and deep brain stimulation (DBS) through a systematic review and meta‐analysis.
L. Touma, Bénédicte Dansereau, A. Chan, N. Jetté, C. Kwon, K. Braun, D. Friedman, L. Jehi, J. Rolston, Sumeet Vadera, L. Wong-Kisiel, D. Englot, M. Keezer   +12 more
semanticscholar   +1 more source

Drug Tolerance, Drug Addiction, and Drug Anticipation

Current Directions in Psychological Science, 2005
Environmental cues associated with drugs often elicit withdrawal symptoms and relapse to drug use. Such cues also modulate drug tolerance. The contribution of drug-associated stimuli to withdrawal and tolerance is emphasized in a Pavlovian-conditioning analysis of drug administration.
openaire   +1 more source

Drug Tolerance by Tritrichomonas foetus

The Journal of Parasitology, 1967
A strain of Tritrichomonas foetus that remained refractory to dimetridazole, despite four courses of successively higher levels of medication (strain 4711, McLoughlin, 1965), was recovered from a bull and established intravaginally in hamsters. Tolerance for the chemical remained undiminished after maintenance of the strain in hamsters for 27 months ...
openaire   +2 more sources

Cholinergic drug interactions and heat tolerance

Life Sciences, 1994
Acute, subchronic and chronic exposures to cholinergic compounds may result in differing effects. The efficacy of pyridostigmine bromide (PY) prophylaxis against organophosphorus poisoning depends on post exposure atropine (AT) administration. AT induces a dose-dependent increase in rate of rise of core temperature in heat exposed humans and rats.
C B, Matthew, J F, Glenn, W D, Bowers, D K, Navara   +3 more
openaire   +2 more sources

Safety and tolerability of available urate-lowering drugs: a critical review

Expert Opinion on Drug Safety, 2019
Introduction: Urate-lowering therapy (ULT) is the cornerstone of gout management, which is a widespread chronic illness characterized by hyperuricemia, arthropathy, tophus development, and urolithiasis. Since asymptomatic increased serum urate levels are
L. Strilchuk, F. Fogacci, A. Cicero
semanticscholar   +1 more source

Tolerance to Drugs, especially to Morphine

Nature, 1960
VARIOUS theories have been put forward to elucidate the development of tolerance to a drug. For example, it has been observed by Zauder1 that “as tolerance develops (in the rat), the amount of morphine appearing in the urine decreases”. This was in accordance with Gross and Thomson's observations on the dog2. Cochin et al.
G, NADEAU, G, SOBOLEWSKI
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Drug-Induced Disorders of Glucose Tolerance

Annals of Internal Medicine, 1993
To review the medications that influence glucose metabolism and to examine the mechanisms of these medications on glucose metabolism.Data were obtained from a MEDLINE search back to 1966 and included animal and human studies published in the English language.Approximately 80% of original publications were included after review by the authors.
M K, Pandit, J, Burke, A B, Gustafson, A, Minocha, A N, Peiris   +4 more
openaire   +2 more sources

Pharmacology of Cenobamate: Mechanism of Action, Pharmacokinetics, Drug–Drug Interactions and Tolerability

CNS Drugs, 2021
R. Roberti, C. De Caro, L. Iannone, G. Zaccara, S. Lattanzi, E. Russo   +5 more
semanticscholar   +1 more source

The relation between drug exposure and tolerance: contingent drug tolerance reexamined

2009
The finding that the performance of a response during periods of drug exposure facilitates the development of tolerance to the effects of the drug on that response is commonly referred to as contingent drug tolerance. Contingent tolerance is typically demonstrated in before-and-after design experiments.
openaire   +1 more source