Results 51 to 60 of about 4,643,128 (344)

Status Epilepticus in the Elderly

International Journal of Gerontology, 2016
Status epilepticus is a life-threatening neurologic emergency. The elderly constitute the largest and fastest continuously growing population among patients with status epilepticus.
Lu-An Chen, Shuo-Bin Jou
doaj   +1 more source

New players in the preventive treatment of migraine. [PDF]

, 2015
Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed ...
Mitsikostas, Dimos D, Rapoport, Alan M
core   +3 more sources

Efficacy and tolerability of antiseizure drugs [PDF]

Therapeutic Advances in Neurological Disorders, 2021
Drug-resistant epilepsy occurs in 25–30% of patients. Furthermore, treatment with a first-generation antiseizure drug (ASD) fails in 30–40% of individuals because of their intolerable adverse effects. Over the past three decades, 20 newer- (second- and third-)generation ASDs with unique mechanisms of action and pharmacokinetic profiles have been ...
openaire   +3 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Evaluating gastrointestinal side effects and discontinuation rates of semaglutide in routine clinical practice: A prospective observational study.

Student's Journal of Health Research Africa
Background: Semaglutide, a GLP-1 receptor agonist, has demonstrated significant efficacy in glycemic control and weight reduction in Type 2 Diabetes Mellitus (T2DM).
Monika Patel Kodela, Dr.N.O.A. Sasi, Dr . P. P. Rama Rao Pamarthy   +2 more
doaj   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Early Experience of Treprostinil Dry‐Powdered Inhaler in Patients With Pulmonary Hypertension Related to Fibrosing Interstitial Lung Disease at a Tertiary Referral Center

Pulmonary Circulation
A dry powder inhaler (DPI) formulation of treprostinil was FDA‐approved in March 2022 for patients with pulmonary arterial hypertension or pulmonary hypertension associated with ILD (PH‐ILD).
Jordin L. Rice, Ann Randall, Darlene Kim, Vera Pillitteri, Tim Lahm, Zulma X. Yunt, Jeffrey J. Swigris, M. Patricia George   +7 more
doaj   +1 more source

Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study [PDF]

, 2019
Background: Dry eye disease (DED) affects more than 14% of the elderly population causing decrease of quality of life, high costs and vision impairment.
Allegretti, M., Ferrari, M., Garhoefer, G., Lambiase, A., Mantelli, F., Sacchetti, M., Schmetterer, L., Schmidl, D.   +7 more
core   +1 more source

Drug Tolerance in Mycobacterium tuberculosis [PDF]

Antimicrobial Agents and Chemotherapy, 1999
ABSTRACT Although Mycobacterium tuberculosis is eradicated rapidly during therapy in some patients with pulmonary tuberculosis, it can persist for many months in others. This study examined the relationship between mycobacterial drug tolerance (delayed killing in vitro), persistence, and relapse.
R S, Wallis, S, Patil, S H, Cheon, K, Edmonds, M, Phillips, M D, Perkins, M, Joloba, A, Namale, J L, Johnson, L, Teixeira, R, Dietze, S, Siddiqi, R D, Mugerwa, K, Eisenach, J J, Ellner   +14 more
openaire   +2 more sources