Results 71 to 80 of about 4,643,128 (344)

Patient acceptability, safety and access : A balancing act for selecting age-appropriate oral dosage forms for paediatric and geriatric populations [PDF]

, 2018
© 2017 Elsevier B.V. All rights reserved.The selection and design of age-appropriate formulations intended for use in paediatric and geriatric patients are dependent on multiple factors affecting patient acceptability, safety and access.
Ernest, Terry B., Liu, Fang, Ranmal, Sejal R., Walsh, Jennifer   +3 more
core   +2 more sources

Drug resistance and tolerance in fungi

Nature Reviews Microbiology, 2020
Systemic fungal infections pose a serious clinical problem. Treatment options are limited, and antifungal drug resistance is increasing. In addition, a substantial proportion of patients do not respond to therapy despite being infected with fungi that are susceptible to the drug.
Judith Berman, Damian J. Krysan
openaire   +3 more sources

A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects

Drug Delivery and Translational Research, 2021
Biotherapeutics are highly efficacious, but the pain and inconvenience of chronic injections lead to poor patient compliance and compromise effective disease management.
A. Dhalla, Ziad Al-Shamsie, S. Beraki, Anvesh K. R. Dasari, Leonard C. Fung, L. Fusaro, Anusha Garapaty, Betsy Gutierrez, Delia Gratta, Mir Hashim, Kyle P. Horlen, P. Karamchedu, Radhika Korupolu, E. Liang, Chang Ong, Zachary Owyang, Vasudha Salgotra, Shilpy Sharma, Baber Syed, M. Syed, A. Vo, Radia Abdul-Wahab, Asad Wasi, Alyson Yamaguchi, S. Yen, M. Imran   +25 more
semanticscholar   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Pharmacokinetic Drug Interaction Between Amlodipine and Tadalafil: An Open-Label, Randomized, Multiple-Dose Crossover Study in Healthy Male Volunteers

Drug Design, Development and Therapy, 2022
Hyungsub Kim,1 Shi Hyang Lee,2 Jina Jung,3 Sunghee Hong,3 Hyeong-Seok Lim2 1Department of Emergency Medical Services, College of Health Sciences, Eulji University, Seongnam, Republic of Korea; 2Department of Clinical Pharmacology and Therapeutics, Asan ...
Kim H, Lee SH, Jung J, Hong S, Lim HS
doaj  

The practice of using a domestic antiviral drug in the etiotropic therapy of acute respiratory viral infection

Терапевтический архив, 2020
Aim.Evaluation of efficacy, safety, tolerability, and determination of the optimal dose of riamilovir in patients diagnosed with acute respiratory viral infection (ARVI). Materials and methods.The study included 270 patients with uncomplicated ARVI of
D. A. Lioznov, I. I. Tokin, T. G. Zubkova, P. V. Sorokin   +3 more
doaj   +1 more source

Defective DNA repair mechanisms in prostate cancer: impact of olaparib [PDF]

, 2017
The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects.
De Felice, Francesca, Marampon, Francesco, Marchetti, Claudia, Musella, Angela, Tombolini, Vincenzo   +4 more
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Stimulant drug effects on attention deficit/hyperactivity disorder: a review of the effects of age and sex of patients [PDF]

, 2010
Objective: As dopamine functioning varies by sex and age it might be expected that the effects of methylphenidate or amfetamine, the psychostimulants used for the treatment of Attention Deficit /Hyperactivity Disorder (ADHD), will also be moderated by ...
Barke, Edmund, Coghill, David, Cornforth, Christine   +2 more
core   +1 more source

Possibilities to Improve the Therapy of the Patients with Ureteral Concretions [PDF]

, 2017
The aim of the given study was to improve the results of treatment of patients with concretions of the upper third of the ureter.Materials and methods. The clinical trial was carried out as a non-interventional open, controlled, in two groups of patients
Chabanov, P. (Pavel), Sabadash, M. (Maksym), Shulyak, A. (Alexandr)   +2 more
core   +2 more sources