Results 161 to 170 of about 393,807 (266)

Multiscale Profiling of Nanoscale Metal‐Organic Framework Biocompatibility and Immune Interactions

Advanced Healthcare Materials, EarlyView.
A multi‐scale, hierarchical ‘Safety‐by‐Design’ pipeline combining machine learning, ex vivo human blood assays, and in vivo models enables the systematic immunotoxicity and biocompatibility profiling of nanoscale metal‐organic frameworks, accelerating their safe clinical translation. Abstract The clinical translation of metal‐organic frameworks (MOFs) –
Yunhui Zhuang, Bárbara B. Mendes, Dhruv Menon, Jhenifer Oliveira, Xu Chen, Fatma Demir Duman, João Conniot, Sergio Mercado, Xiewen Liu, Shi‐Yuan Zhang, João Conde, Rachel E. Hewitt, David Fairen‐Jimenez   +12 more
wiley   +1 more source

Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis [PDF]

, 2019
Jae Jin Lee, Sun‐Kyung Lee, Naomi Song, Temitope O. Nathan, Benjamin M. Swarts, Seok-Yong Eum, Sabine Ehrt, Sang-Nae Cho, Hyungjin Eoh   +8 more
openalex   +1 more source

A Targeted Redox‐Active Dual‐Action Pt(IV)‐Mn(II) Prodrug Displays Enhanced In Vivo Anticancer Activity

Advanced Healthcare Materials, EarlyView.
A new oxaliplatin‐based Pt(IV) prodrug bearing a Mn(II) superoxide dismutase mimic is synthesized and studied, in vitro and in vivo, in the context of colorectal cancer. Encapsulation of this prodrug in an easy‐to‐implement PEGylated micelle formulation demonstrated the highest in vivo anticancer activity among all the tested conditions, supporting the
Alvaro Lopez‐Sanchez, Henri Chédotal, Ram Pravin Kumar Muthuramalingam, Marine Thomas, Jia Ning Nicolette Yau, Priya Ranjan Sahoo, Clotilde Policar, Frédéric Batteux, Kadda Medjoubi, Andrea Somogyi, Giulia Adriani, Carole Nicco, Romain Coriat, Giorgia Pastorin, Hélène C. Bertrand   +14 more
wiley   +1 more source

Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells

, 2016
Yingying Pu, Zhilun Zhao, Yingxing Li, Jin Zou, Qi Ma, Yanna Zhao, Yuehua Ke, Yun Zhu, Huiyi Chen, Matthew A. B. Baker, Hao Ge, Yujie Sun, X. Sunney Xie, Fan Bai   +13 more
openalex   +1 more source

Cell migration, chimerism, and graft acceptance: with particular reference to the liver [PDF]

, 1996
Demetris, AJ, Murase, N, Ricordi, C, Starzl, TE, Trucco, M   +4 more
core  

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source

Effects of caffeine on cognitive and autonomic measures in heavy and light caffeine consumers [PDF]

, 2004
Anderson, Andrews, Arnett, Barone, Beck, Beck, Berman, Bornstein, Boulenger, Bruce, Bruce, Bruce, Bättig, Bättig, Cameron, Charney, D'Amicis, Daly, Daly, Davidson, Deborah Matica, Drewe, Edwards, Erikson, Evans, Eysenck, Feldman, Foreman, Garrett, Gilbert, Hasenfratz, Heaton, Heishman, Henik, Hertz, Hindmarch, Hughes, James, James, Janine Brooks, Julien, Kenemans, Kenemans, Lane, Loke, Loke, Lyvers, Lyvers, Lyvers, Lyvers, Lyvers, Lyvers, Lyvers, MacLeod, Malloy, Maltzman, Mathew, Meyer, Michael Lyvers, Milner, Mountain, Nehlig, Newman, Osman, Patat, Phillips-Bute, Quinlan, Rees, Richardson, Riedel, Robelin, Rogers, Rogers, Rusted, Smith, Smith, Spielberger, SPSS Inc., Stelt, Stewart, Stuss, Till, Warburton, White, Zahn   +84 more
core   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Drug-tolerant persister cancer cells

Journal of the National Cancer Center
Pengliang Wang, Bin Ke, Gang Ma
openaire   +3 more sources

Coordinated Development of Immune Cell Populations in Vascularized Skin Organoids from Human Induced Pluripotent Stem Cells

Advanced Healthcare Materials, EarlyView.
Vascularized skin organoids are developed from human induced pluripotent stem cells and contain macrophages, Langerhans cells, and neutrophils. Vascularized skin organoids offer a transformative platform to model skin biology and enable mechanistic investigations of inflammatory and hematologic skin disorders.
Mitchell Mostina, Jane Sun, Seen Ling Sim, Imaan A. Ahmed, Fernando Souza‐Fonesca‐Guimaraes, Ernst J. Wolvetang, Jason Brown, Snehlata Kumari, Kiarash Khosrotehrani, Abbas Shafiee   +9 more
wiley   +1 more source