Results 161 to 170 of about 5,099,978 (377)
Aging and Cancer, EarlyView.Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley +1 more source
House of cellulose – a new hideout for drug tolerant Mycobacterium tuberculosis
Microbial Cell, 2016 Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB). The treatment of TB requires administration of multiple drugs for long durations because of the unusual drug tolerance of Mtb. The phenotypic drug tolerance of genetically drug-susceptible Mtb in
Ashwani Kumar
doaj +1 more source
CMINNs: Compartment Model Informed Neural Networks -- Unlocking Drug Dynamics [PDF]
arXivIn the field of pharmacokinetics and pharmacodynamics (PKPD) modeling, which plays a pivotal role in the drug development process, traditional models frequently encounter difficulties in fully encapsulating the complexities of drug absorption, distribution, and their impact on targets.
arxiv
Quantitative Analysis of the Tumor/Metastasis System and its Optimal Therapeutic Control [PDF]
arXiv, 2013 A mathematical model for time development of metastases and their distribution in size and carrying capacity is presented. The model is used to theoretically investigate anti-cancer therapies such as surgery and chemical treatments (cytotoxic or anti-angiogenic), in monotherapy or in combination.
arxiv
MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs
Nature Communications, 2015 Toxin–antitoxin (TA) systems are highly conserved in members of the Mycobacterium tuberculosis (Mtb) complex and have been proposed to play an important role in physiology and virulence.
P. Tiwari +5 more
semanticscholar +1 more source
Weaning of immunosuppression in long - Term liver transplant recipients [PDF]
, 1995 Seventy-two long-surviving liver transplant recipients were evaluated prospectively, including a baseline allograft biopsy for weaning off of immunosuppression.
Abu-Elmagd, K +11 more
core +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Background Volumetric modulated arc therapy (VMAT) requires an accurate patient‐specific quality assurance (PSQA) program. In clinical practice, this is usually performed using the γ‐index and the two‐dimensional gamma passing rate (2D %GP). A three‐dimensional (3D) index incorporating the patient anatomy could be more useful for the 3D dose ...
Christos Zarros +6 more
wiley +1 more source
A Nonparametric Bayesian Design for Drug Combination Cancer Trials [PDF]
arXiv, 2019 We propose an adaptive design for early phase drug combination cancer trials with the goal of estimating the maximum tolerated dose (MTD). A nonparametric Bayesian model, using beta priors truncated to the set of partially ordered dose combinations, is used to describe the probability of dose limiting toxicity (DLT).
arxiv
Distinct histone modifications denote early stress-induced drug tolerance in cancer
OncoTarget, 2017 Besides somatic mutations or drug efflux, epigenetic reprogramming can lead to acquired drug resistance. We recently have identified early stress-induced multi-drug tolerant cancer cells termed induced drug-tolerant cells (IDTCs).
A. Emran +19 more
semanticscholar +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose Single‐isocenter multitarget (SIMT) radiosurgery has become increasingly popular as advancement in planning and delivery systems have made this approach clinically viable. With targets varying in size and distance from isocenter, SIMT plans are highly complex with dynamic multileaf collimator (MLC) motion.
Hem Moktan +3 more
wiley +1 more source