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Antifungal Tolerance and Resistance Emerge at Distinct Drug Concentrations and Rely upon Different Aneuploid Chromosomes [PDF]

MBio, 2023
Antifungal drug tolerance is a response distinct from resistance, in which cells grow slowly above the MIC. Here, we found that the majority (69.2%) of 133 Candida albicans clinical isolates, including standard lab strain SC5314, exhibited temperature ...
Eduardo Scopel, Judith Berman, Feng Yang   +2 more
exaly   +2 more sources

Mechanisms of Drug-Induced Tolerance in Mycobacterium tuberculosis [PDF]

Clinical Microbiology Reviews, 2020
: Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis populations that are temporarily able to survive antibiotic pressure in the absence of drug resistance-conferring mutations, a phenomenon termed drug tolerance.
Annelies Van Rie, Sander Goossens, Samantha Sampson   +2 more
exaly   +3 more sources

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Tolerance and cross-tolerance among psychotomimetic drugs

Psychopharmacologia, 1968
A fixed-ratio schedule of milk reinforcement (FR 30) was used to study tolerance to the effects of d-LSD, l-LSD, BOL, psilocybin, mescaline, and d-amphetamine in the rat. A decrease in the amount of disruption of bar-pressing occurs with repeated daily administration of appropriate doses of all of the “psychotomimetic” compounds, and cross-tolerance ...
J B, Appel, D X, Freedman
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Drug-induced Immunological Tolerance

Nature, 1959
PREVIOUS work in this laboratory demonstrated that administration of a purine analogue, 6-mercaptopurine, suppressed the antibody response to a soluble antigen (human serum albumin) in rabbits1. It was shown that the antimetabolite could block completely the primary immune response to the purified protein antigen; its effect on the secondary response ...
R, SCHWARTZ, W, DAMESHEK
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Receptor alterations and drug tolerance

Life Sciences, 1979
Abstract A brief review of studies which have employed chronic administration of anticholinesterases, benzodiazepines, amphetamine, antidepressants, neuroleptics and opiates is presented to illustrate the deficiencies in our current knowledge about the degree to which alterations in neurotransmitter receptors can account for tolerance development to ...
D H, Overstreet, H I, Yamamura
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Tolerance to Drugs, especially to Morphine

Nature, 1960
VARIOUS theories have been put forward to elucidate the development of tolerance to a drug. For example, it has been observed by Zauder1 that “as tolerance develops (in the rat), the amount of morphine appearing in the urine decreases”. This was in accordance with Gross and Thomson's observations on the dog2. Cochin et al.
G, NADEAU, G, SOBOLEWSKI
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Tolerance and sensitization to the behavioral effects of drugs

Behavioural Pharmacology, 1993
Tolerance and sensitization are relatively simple manifestations of learning and memory that refer to decreases and increases in the strength of a response to a stimulus induced by past experiences with the same or related stimuli. In the context of the study of drugs, tolerance refers to the decreased effectiveness of a given drug with repeated ...
STEWART J, BADIANI, Aldo
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Drug Tolerance by Tritrichomonas foetus

The Journal of Parasitology, 1967
A strain of Tritrichomonas foetus that remained refractory to dimetridazole, despite four courses of successively higher levels of medication (strain 4711, McLoughlin, 1965), was recovered from a bull and established intravaginally in hamsters. Tolerance for the chemical remained undiminished after maintenance of the strain in hamsters for 27 months ...
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Mechanism of Drug Addiction and Drug Tolerance

Nature, 1941
IT has been found that prolonged administration of ‘luminal’ (and other barbiturates) to human beings (for example, epileptics) and animals greatly reduces the cholinesterase activity of the serum, so that it reaches 10–20 per cent of what it was before the treatment with the drug.
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Drug resistance and drug tolerance in parasites

Trends in Parasitology, 2006
In their recent Trends in Parasitology article on tolerance and antimalarial drug resistance, Hastings and Watkins [1xTolerance is the key to understanding antimalarial drug resistance. Hastings, I.M. and Watkins, W.M. Trends Parasitol. 2006; 22: 71–77Abstract | Full Text | Full Text PDF | PubMed | Scopus (50)See all References][1] made the extremely ...
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