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Drug-induced Immunological Tolerance
Nature, 1959PREVIOUS work in this laboratory demonstrated that administration of a purine analogue, 6-mercaptopurine, suppressed the antibody response to a soluble antigen (human serum albumin) in rabbits1. It was shown that the antimetabolite could block completely the primary immune response to the purified protein antigen; its effect on the secondary response ...
R, SCHWARTZ, W, DAMESHEK
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Tolerance and cross-tolerance among psychotomimetic drugs
Psychopharmacologia, 1968A fixed-ratio schedule of milk reinforcement (FR 30) was used to study tolerance to the effects of d-LSD, l-LSD, BOL, psilocybin, mescaline, and d-amphetamine in the rat. A decrease in the amount of disruption of bar-pressing occurs with repeated daily administration of appropriate doses of all of the “psychotomimetic” compounds, and cross-tolerance ...
J B, Appel, D X, Freedman
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Reductive Stress: New Insights in Physiology and Drug Tolerance of Mycobacterium
Antioxidants and Redox Signaling, 2020Significance: Mycobacterium tuberculosis (Mtb) encounters reductive stress during its infection cycle. Notably, host-generated protective responses, such as acidic pH inside phagosomes and lysosomes, exposure to glutathione in alveolar hypophase (i.e., a
Parminder Singh Mavi +2 more
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Occasion setting and drug tolerance
Integrative Physiological & Behavioral Science, 2002There is considerable evidence that drug-paired cues become associated with drug effects. It has been hypothesized that these cues act as Pavlovian conditional stimuli (CSs), and elicit conditional compensatory responses that contribute to tolerance.
Barbara M C, Ramos +2 more
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Receptor alterations and drug tolerance
Life Sciences, 1979Abstract A brief review of studies which have employed chronic administration of anticholinesterases, benzodiazepines, amphetamine, antidepressants, neuroleptics and opiates is presented to illustrate the deficiencies in our current knowledge about the degree to which alterations in neurotransmitter receptors can account for tolerance development to ...
D H, Overstreet, H I, Yamamura
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Proteomic analyses identify a novel role for EZH2 in the initiation of cancer cell drug tolerance.
Journal of Proteome Research, 2020Acquisition of drug resistance remains a chief impediment to successful cancer therapy, and we previously described a transient drug-tolerant cancer cell population (DTPs) whose survival is in part dependent on the activities of the histone ...
Victoria C. Pham +10 more
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Drug Tolerance, Drug Addiction, and Drug Anticipation
Current Directions in Psychological Science, 2005Environmental cues associated with drugs often elicit withdrawal symptoms and relapse to drug use. Such cues also modulate drug tolerance. The contribution of drug-associated stimuli to withdrawal and tolerance is emphasized in a Pavlovian-conditioning analysis of drug administration.
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Drug Tolerance by Tritrichomonas foetus
The Journal of Parasitology, 1967A strain of Tritrichomonas foetus that remained refractory to dimetridazole, despite four courses of successively higher levels of medication (strain 4711, McLoughlin, 1965), was recovered from a bull and established intravaginally in hamsters. Tolerance for the chemical remained undiminished after maintenance of the strain in hamsters for 27 months ...
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