Results 281 to 290 of about 5,956,077 (339)
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Advanced Drug Delivery Reviews, 2023
Human pathogenic fungi pose a serious threat to human health and safety. Unfortunately, the limited number of antifungal options is exacerbated by the continuous emergence of drug-resistant variants, leading to frequent drug treatment failures.
Lei Chen +7 more
semanticscholar +3 more sources
Human pathogenic fungi pose a serious threat to human health and safety. Unfortunately, the limited number of antifungal options is exacerbated by the continuous emergence of drug-resistant variants, leading to frequent drug treatment failures.
Lei Chen +7 more
semanticscholar +3 more sources
Drug-induced Immunological Tolerance
Nature, 1959PREVIOUS work in this laboratory demonstrated that administration of a purine analogue, 6-mercaptopurine, suppressed the antibody response to a soluble antigen (human serum albumin) in rabbits1. It was shown that the antimetabolite could block completely the primary immune response to the purified protein antigen; its effect on the secondary response ...
R, SCHWARTZ, W, DAMESHEK
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Tolerance and cross-tolerance among psychotomimetic drugs
Psychopharmacologia, 1968A fixed-ratio schedule of milk reinforcement (FR 30) was used to study tolerance to the effects of d-LSD, l-LSD, BOL, psilocybin, mescaline, and d-amphetamine in the rat. A decrease in the amount of disruption of bar-pressing occurs with repeated daily administration of appropriate doses of all of the “psychotomimetic” compounds, and cross-tolerance ...
J B, Appel, D X, Freedman
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Reductive Stress: New Insights in Physiology and Drug Tolerance of Mycobacterium
Antioxidants and Redox Signaling, 2020Significance: Mycobacterium tuberculosis (Mtb) encounters reductive stress during its infection cycle. Notably, host-generated protective responses, such as acidic pH inside phagosomes and lysosomes, exposure to glutathione in alveolar hypophase (i.e., a
Parminder Singh Mavi +2 more
semanticscholar +1 more source
Occasion setting and drug tolerance
Integrative Physiological & Behavioral Science, 2002There is considerable evidence that drug-paired cues become associated with drug effects. It has been hypothesized that these cues act as Pavlovian conditional stimuli (CSs), and elicit conditional compensatory responses that contribute to tolerance.
Barbara M C, Ramos +2 more
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Receptor alterations and drug tolerance
Life Sciences, 1979Abstract A brief review of studies which have employed chronic administration of anticholinesterases, benzodiazepines, amphetamine, antidepressants, neuroleptics and opiates is presented to illustrate the deficiencies in our current knowledge about the degree to which alterations in neurotransmitter receptors can account for tolerance development to ...
D H, Overstreet, H I, Yamamura
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International Journal of Pediatric Otorhinolaryngology, 2019
OBJECTIVE Sialorrhea complicated by aspiration is a primary source of morbidity and mortality in neurologically impaired children. Anticholinergics are an effective treatment option, but have traditionally been considered only adjuncts due to ...
J. Dohar
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OBJECTIVE Sialorrhea complicated by aspiration is a primary source of morbidity and mortality in neurologically impaired children. Anticholinergics are an effective treatment option, but have traditionally been considered only adjuncts due to ...
J. Dohar
semanticscholar +1 more source
Drug Tolerance, Drug Addiction, and Drug Anticipation
Current Directions in Psychological Science, 2005Environmental cues associated with drugs often elicit withdrawal symptoms and relapse to drug use. Such cues also modulate drug tolerance. The contribution of drug-associated stimuli to withdrawal and tolerance is emphasized in a Pavlovian-conditioning analysis of drug administration.
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Bioanalysis, 2019
Aim: Neutralizing anti-drug antibody (NAb) assays are inherently prone to the interference from drug and its soluble target, potentially resulting in erroneous results.
Bonnie Wu +4 more
semanticscholar +1 more source
Aim: Neutralizing anti-drug antibody (NAb) assays are inherently prone to the interference from drug and its soluble target, potentially resulting in erroneous results.
Bonnie Wu +4 more
semanticscholar +1 more source