Results 1 to 10 of about 6,137,811 (297)

Drug effectiveness or drug toxicity?

La Pediatria Medica e Chirurgica, 2012
Not ...
Luca Rosti
doaj   +5 more sources

Synthesis, DFT Study, and In Vitro Evaluation of Antioxidant Properties and Cytotoxic and Cytoprotective Effects of New Hydrazones on SH-SY5Y Neuroblastoma Cell Lines

Pharmaceuticals, 2023
A series of ten new hydrazide–hydrazone derivatives bearing a pyrrole ring were synthesized and structurally elucidated through appropriate spectral characteristics. The target hydrazones were assessed for radical scavenging activity through 1,1-diphenyl-
Diana Tzankova, Hristina Kuteva, Emilio Mateev, Denitsa Stefanova, Alime Dzhemadan, Yordan Yordanov, Alexandrina Mateeva, Virginia Tzankova, Magdalena Kondeva-Burdina, Alexander Zlatkov, Maya Georgieva   +10 more
doaj   +1 more source

In Silico Evaluation and In Vitro Determination of Neuroprotective and MAO-B Inhibitory Effects of Pyrrole-Based Hydrazones: A Therapeutic Approach to Parkinson’s Disease

Molecules, 2022
Parkinson’s disease is a huge burden in modern medicinal practice. A serious drawback of current antiparkinsonian therapy is its symptomatic nature. This directed our investigations in the search for new more potent derivatives, affecting not only the ...
Magdalena Kondeva-Burdina, Emilio Mateev, Borislav Angelov, Virginia Tzankova, Maya Georgieva   +4 more
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Study on the Neuroprotective, Radical-Scavenging and MAO-B Inhibiting Properties of New Benzimidazole Arylhydrazones as Potential Multi-Target Drugs for the Treatment of Parkinson’s Disease

Antioxidants, 2022
Oxidative stress is a key contributing factor in the complex degenerating cascade in Parkinson’s disease. The inhibition of MAO-B affords higher dopamine bioavailability and stops ROS formation.
Neda Anastassova, Denitsa Aluani, Nadya Hristova-Avakumova, Virginia Tzankova, Magdalena Kondeva-Burdina, Miroslav Rangelov, Nadezhda Todorova, Denitsa Yancheva   +7 more
doaj   +1 more source

Therapy of pancreatic cancer via an EphA2 receptor-targeted delivery of gemcitabine. [PDF]

, 2016
First line treatment for pancreatic cancer consists of surgical resection, if possible, and a subsequent course of chemotherapy using the nucleoside analogue gemcitabine.
Barile, Elisa, Das, Swadesh K, De, Surya K, Emdad, Luni, Fisher, Paul B, Morvaridi, Susan Kharagh, Pandol, Stephen J, Pellecchia, Maurizio, Quinn, Bridget A, Sarkar, Devanand, Stebbins, John L, Wang, Si   +11 more
core   +5 more sources

Mitochondrial Respiratory Complexes as Targets of Drugs: The PPAR Agonist Example

Cells, 2022
Mitochondrial bioenergetics are progressively acquiring significant pathophysiological roles. Specifically, mitochondria in general and Electron Respiratory Chain in particular are gaining importance as unintentional targets of different drugs.
Patrizia Bottoni, Alessandro Pontoglio, Salvatore Scarà, Luisa Pieroni, Andrea Urbani, Roberto Scatena   +5 more
doaj   +1 more source

Toxicometabolomics: Small Molecules to Answer Big Toxicological Questions

Metabolites, 2021
Given the high biological impact of classical and emerging toxicants, a sensitive and comprehensive assessment of the hazards and risks of these substances to organisms is urgently needed.
Ana Margarida Araújo, Félix Carvalho, Paula Guedes de Pinho, Márcia Carvalho   +3 more
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Impossibility of the treatment of inoperable liver multicystic echinococcosis due to adverse reactions to antihelminitics [PDF]

Vojnosanitetski Pregled, 2009
Introduction. In some cases of multicystic forms of liver echinococcal disease, the advanced method for treatment of cystic echinococcosis faces great problems relating to the final outcome of the treatment. Case report.
Mikić Dragan, Jevtić Miodrag, Arsić-Komljenović Gordana, Ristanović Elizabeta, Stanković Nebojša, Sjeničić Goran, Janićijević-Hudomal Snežana   +6 more
doaj   +1 more source

Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt

eLife, 2023
The maintenance of the functional integrity of the intestinal epithelium requires a tight coordination between cell production, migration, and shedding along the crypt–villus axis.
Louis Gall, Carrie Duckworth, Ferran Jardi, Lieve Lammens, Aimee Parker, Ambra Bianco, Holly Kimko, David Mark Pritchard, Carmen Pin   +8 more
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Adverse effects of long term, continual administration of high doses of albendazole in the treatment of echinococcal disease [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Modern treatment of cystic echinococcosis, except for surgical treatment and percutaneous drainage of cyst considers also administration of albendazole as a type of individual therapy.
Jevtić Miodrag, Mikić Dragan, Arsić-Komljenović Gordana, Stanković Nebojša, Ristanović Elizabeta, Sjeničić Goran, Janićijević-Hudomal Snežana   +6 more
doaj   +1 more source