Results 1 to 10 of about 602,162 (221)

Drug effectiveness or drug toxicity?

La Pediatria Medica e Chirurgica, 2012
Not ...
Luca Rosti
doaj   +5 more sources

Drug toxicity and surveillance in children [PDF]

British Journal of Clinical Pharmacology, 1996
The use of medicines in children is an area of increasing after this syndrome was noted, pharmacokinetic studiesinterest [1]. Many medicines are being used outside the showed that newborn infants had impaired metabolismterms of their product licence [2] thereby increasing of chloramphenicol and that a reduction of the dosagethe risk of drug toxicity ...
Andrea Gill, Anthony J Nunn, Imti Choonara   +2 more
openaire   +5 more sources

Studies on the toxicity of drugs

Japanese Journal of Oral Biology, 1981
To study the acute and semi-acute deleterious effects of stomatitis drug (TSO ointment) con -taining shikon extracts on oral mucosa, experiments were made by applying drugs to the labial gingival tissue in the mandible associated with incissors of Wistar male rats and the buccal pouch of male golden hamster.
Akira Fuji, Masako Okayasu, Masumi Mogi, Sumi Kobayashi, Michihiko Yoshizawa, Toyoyuki Tamura   +5 more
openaire   +4 more sources

The molecular basis of drug toxicity [PDF]

Journal of Clinical Pathology, 1975
W. D. M. Paton
openaire   +5 more sources

Synthesis, DFT Study, and In Vitro Evaluation of Antioxidant Properties and Cytotoxic and Cytoprotective Effects of New Hydrazones on SH-SY5Y Neuroblastoma Cell Lines

Pharmaceuticals, 2023
A series of ten new hydrazide–hydrazone derivatives bearing a pyrrole ring were synthesized and structurally elucidated through appropriate spectral characteristics. The target hydrazones were assessed for radical scavenging activity through 1,1-diphenyl-
Diana Tzankova, Hristina Kuteva, Emilio Mateev, Denitsa Stefanova, Alime Dzhemadan, Yordan Yordanov, Alexandrina Mateeva, Virginia Tzankova, Magdalena Kondeva-Burdina, Alexander Zlatkov, Maya Georgieva   +10 more
doaj   +1 more source

In Silico Evaluation and In Vitro Determination of Neuroprotective and MAO-B Inhibitory Effects of Pyrrole-Based Hydrazones: A Therapeutic Approach to Parkinson’s Disease

Molecules, 2022
Parkinson’s disease is a huge burden in modern medicinal practice. A serious drawback of current antiparkinsonian therapy is its symptomatic nature. This directed our investigations in the search for new more potent derivatives, affecting not only the ...
Magdalena Kondeva-Burdina, Emilio Mateev, Borislav Angelov, Virginia Tzankova, Maya Georgieva   +4 more
doaj   +1 more source

Study on the Neuroprotective, Radical-Scavenging and MAO-B Inhibiting Properties of New Benzimidazole Arylhydrazones as Potential Multi-Target Drugs for the Treatment of Parkinson’s Disease

Antioxidants, 2022
Oxidative stress is a key contributing factor in the complex degenerating cascade in Parkinson’s disease. The inhibition of MAO-B affords higher dopamine bioavailability and stops ROS formation.
Neda Anastassova, Denitsa Aluani, Nadya Hristova-Avakumova, Virginia Tzankova, Magdalena Kondeva-Burdina, Miroslav Rangelov, Nadezhda Todorova, Denitsa Yancheva   +7 more
doaj   +1 more source

Toxicity Detection in Drug Candidates using Simplified Molecular-Input Line-Entry System [PDF]

International Journal of Computer Applications 175(21):1-4, September 2020, 2021
The need for analysis of toxicity in new drug candidates and the requirement of doing it fast have asked the consideration of scientists towards the use of artificial intelligence tools to examine toxicity levels and to develop models to a degree where they can be used commercially to measure toxicity levels efficiently in upcoming drugs.
arxiv   +1 more source

Application Progress of Organoids in Colorectal Cancer

Frontiers in Cell and Developmental Biology, 2022
Currently, colorectal cancer is still the third leading cause of cancer-related mortality, and the incidence is rising. It is a long time since the researchers used cancer cell lines and animals as the study subject. However, these models possess various
Lianxiang Luo, Lianxiang Luo, Lianxiang Luo, Yucui Ma, Yilin Zheng, Jiating Su, Guoxin Huang   +6 more
doaj   +1 more source

Incidence, risk factors and ophthalmic clinical characteristic of ethambutol-induced optic neuropathy: 7-year experience

Frontiers in Ophthalmology, 2023
BackgroundThe purpose of this research was to investigate the characteristics, clinical manifestations, incidence, and risk factors in ethambutol-induced optic neuropathy (EON) in the Thai population.MethodsPatients treated with ethambutol for ...
Pareena Chaitanuwong, Pareena Chaitanuwong, Supaporn Srithawatpong, Supaporn Srithawatpong, Paisan Ruamviboonsuk, Paisan Ruamviboonsuk, Supanut Apinyawasisuk, Supanut Apinyawasisuk, Akechanok Watcharapanjamart, Akechanok Watcharapanjamart, Heather E. Moss, Heather E. Moss   +11 more
doaj   +1 more source