Results 91 to 100 of about 6,137,811 (297)
Psychosis associated with acute recreational drug toxicity: a European case series
BMC Psychiatry, 2016 BackgroundPsychosis can be associated with acute recreational drug and novel psychoactive substance (NPS) toxicity. However, there is limited data available on how common this is and which drugs are most frequently implicated. We describe a European case
O. M. Vallersnes +7 more
semanticscholar +1 more source
Phenylboronic acid-diol crosslinked 6-O-vinylazeloyl-d-galactose nanocarriers for insulin delivery [PDF]
, 2017 A new block polymer named poly 3-acrylamidophenylboronic acid-b-6-O–vinylazeloyl-d-galactose (p(AAPBA-b-OVZG)) was prepared using 3-acrylamidophenylboronic acid (AAPBA) and 6-O-vinylazeloyl-D-galactose (OVZG) via a two-step procedure involving S-1 ...
Bremner, David H. +5 more
core +2 more sources
علوم بهداشتی ایران, 2020 Background and Purpose: The dapagliflozin’s safety profile in insulin-treated adult type-1 diabetes mellites (T1DM) patients remains poorly explored. Therefore, this systematic review and meta-analysis compared the risk of all-cause side effects, study ...
Sumanta Saha, Sujata Saha
doaj
Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes
, 2018 An important number of healthy and diseased tissues shows spatial variations in their metabolic capacities across the tissue. The liver is a prime example of such heterogeneity where the gradual changes in various metabolic activities across the liver ...
Eo, Jinsu +4 more
core +2 more sources
Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney. [PDF]
, 2016 BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels.
Girardet, Jean-Luc +12 more
core +2 more sources
Drug Safety, 2004 Malaria, caused mostly by Plasmodium falciparum and P. vivax, remains one of the most important infectious diseases in the world. Antimalarial drug toxicity is one side of the risk-benefit equation and is viewed differently depending upon whether the clinical indication for drug administration is malaria treatment or prophylaxis.
Taylor, W, White, N
openaire +3 more sources
PLoS ONE, 2016 Background There is an increased risk of death due to drug toxicity after release from incarceration. The purpose of this study was to describe the timing, rate and circumstances of drug toxicity deaths following release from incarceration.
E. Groot +9 more
semanticscholar +1 more source
Human corneal cell culture models for drug toxicity studies
Drug Delivery and Translational Research, 2016 In vivo toxicity and absorption studies of topical ocular drugs are problematic, because these studies involve invasive tissue sampling and toxic effects in animal models.
S. Rönkkö +4 more
semanticscholar +1 more source
Drug-induced endocrine toxicity
Folia Pharmacologica Japonica, 2008 内分泌系臓器は，生体の恒常性維持のために体内外からの刺激に対して互いに協調して働くため，ある内分泌系臓器の機能変調は標的臓器のみならず，ときに複数の関連臓器におよぶ病態を引き起こす．また，薬剤による内分泌系臓器の変化に遭遇した際，それが薬剤の直接的な作用によるものか，または他の関連する要因によるものかを考察することは評価上重要なポイントである．さらに薬剤による内分泌系への影響には，ホルモン輸送タンパク質や標的細胞の感受性の差などにより，動物種差や性差があることにも留意する必要がある．本稿では，内分泌系の概観，薬剤の非臨床試験における内分泌毒性の特徴，内分泌毒性評価の進め方，およびin vitro内分泌毒性評価系の有用性について述べた．さらに，化合物により生じる病変が比較的多く認められる副腎，甲状腺 ...
openaire +3 more sources
Journal of Medicinal Chemistry, 2015 Drug development has a high attrition rate, with poor pharmacokinetic and safety properties a significant hurdle. Computational approaches may help minimize these risks.
Douglas E. V. Pires +2 more
semanticscholar +1 more source