Results 121 to 130 of about 6,137,811 (297)
Kidney Organoids: Current Advances and Applications
LifeKidney organoids, derived from stem cells, including pluripotent stem cells and adult progenitor cells, have been reported as three-dimensional in vitro models that reflect key aspects of kidney development, structure, and function.
Hiroyuki Nakanoh +6 more
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Will antibody-drug conjugate and immune checkpoint inhibitor-based combination therapy close the gap between benefit and toxicity in the treatment of cancers? A systematic review and meta-analysis [PDF]
, 2023 Leyin Zhang +6 more
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Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy. [PDF]
, 2014 Activating mutations in FLT3 confer poor prognosis for individuals with acute myeloid leukemia (AML). Clinically active investigational FLT3 inhibitors can achieve complete remissions but their utility has been hampered by acquired resistance and ...
He, Bai-Liang +9 more
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Injectable diblock copolypeptide hydrogel provides platform to maintain high local concentrations of taxol and local tumor control [PDF]
, 2019 Introduction Surgical resection and systemic chemotherapy with temozolomide remain the mainstay for treatment of glioblastoma. However, many patients are not candidates for surgical resection given inaccessible tumor location or poor health status ...
Bernstein, Alexander +9 more
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Frontiers in Molecular BiosciencesIntroduction: Colistin (CMS) is used for the curation of infections caused by multidrug-resistant bacteria. CMS is constrained by toxicity, particularly in kidney and neuronal cells.
I. Barla +9 more
doaj +1 more source
The pathologists role in identifying drug toxicity [PDF]
, 2018 Larry H. Bernstein
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Drug-induced cutaneous toxicity
Folia Pharmacologica Japonica, 2008 皮膚は体の中の最大の器官であり，常に化学物質や環境物質など外界からの刺激に暴露されている．皮膚毒性はその発現機序により，皮膚に触れておこる傷害である接触性皮膚炎（刺激性皮膚炎，アレルギー性接触性皮膚炎，化学熱傷），紫外線との複合作用により引き起こされる光過敏症（光毒性皮膚炎，光アレルギー性接触性皮膚炎），接触性蕁麻疹，化学挫瘡，色素沈着異常，薬疹，毛の異常，爪の異常，腫瘍に大別され，本総説では皮膚の機能・構造およびこれら皮膚毒性の特徴について概説した．近年，特定の分子・遺伝子を標的とする医薬品やナノテクノロジーを利用した医薬品開発が進歩し，新規医薬品の新たなメカニズムによる毒性発現が懸念され，ここで述べた基本的な毒性変化を理解しておくことが重要であろう ...
openaire +3 more sources
Lab-on-Chip for Testing Myelotoxic Effect of Drugs and Chemicals [PDF]
, 2014 This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014) +9 more
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