Results 121 to 130 of about 5,373,155 (364)
FEBS Open Bio, EarlyView.IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He +5 more
wiley +1 more source
Mitochondrial toxicity of drugs
Chimia, 2006 The introduction of this thesis concentrates on the cellular energy supplier and an important instrument in mediating cell death, mitochondrion. First, an overview is given to explain the biochemical properties of this organelle. Then, the role of mitochondria in cell death is discussed, followed by an article about the mitochondrial toxicity of ...
openaire +3 more sources
Alternatives to laboratory animals : ATLA, 2015 Animals are still widely used in drug development and safety tests, despite evidence for their lack of predictive value. In this regard, we recently showed, by producing Likelihood Ratios (LRs) for an extensive data set of over 3,000 drugs with both ...
Jarrod Bailey, M. Thew, M. Balls
semanticscholar +1 more source
Identification of inhibitors of the Salmonella FraB deglycase, a drug target
FEBS Open Bio, EarlyView.A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law +6 more
wiley +1 more source
Frontiers in Pharmacology, 2018 Recreational use of marijuana is associated with few adverse effects, but abuse of synthetic cannabinoids (SCBs) can result in anxiety, psychosis, chest pain, seizures and death.
Rachel D. Hutchison +13 more
doaj +1 more source
Separating host and microbiome contributions to drug pharmacokinetics and toxicity
Science, 2019 Off-target drug metabolism Anything humans swallow is exposed to the foraging and transforming activities of the gut microbiota. This applies to therapeutic drugs as well as food components and can be a major source of interpersonal variation in drug ...
Michael Zimmermann +3 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Pulmonary involvement in rheumatoid arthritis – Another face of the coin
Archives of the Balkan Medical Union, 2018 Rheumatoid arthritis (RA) is a systemic autoimmune disorder that causes progressive, symmetric, erosive destruction of cartilage and bone, which is usually associated with autoantibodies production.
Georgiana Iftimie +7 more
doaj
FEBS Open Bio, EarlyView.We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang +7 more
wiley +1 more source
BMC Bioinformatics, 2011 Background The identification of drug characteristics is a clinically important task, but it requires much expert knowledge and consumes substantial resources.
Tsafnat Guy +4 more
doaj +1 more source