Results 131 to 140 of about 5,373,155 (364)
Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems
The Journal of pharmacy and pharmacology, 2013 Objectives The frontline drug doxorubicin has been used for treating cancer for over 30 years. While providing a cure in select cases, doxorubicin causes toxicity to most major organs, especially life‐threatening cardiotoxicity, which forces the ...
Oktay Tacar, P. Sriamornsak, C. Dass
semanticscholar +1 more source
Hydrogen sulfide repairs testicular damage induced by heat stress in rats
FEBS Open Bio, EarlyView.Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo +6 more
wiley +1 more source
Predicting Toxicity from Gene Expression with Neural Networks [PDF]
arXiv, 2019 We train a neural network to predict chemical toxicity based on gene expression data. The input to the network is a full expression profile collected either in vitro from cultured cells or in vivo from live animals. The output is a set of fine grained predictions for the presence of a variety of pathological effects in treated animals.
arxiv
Discussion on the Toxic Effects of Drugs Used in Neurological and Psychiatric Practice [PDF]
, 1957 openalex +1 more source
Biotechnology Journal, 2019 Recent research has shown that the maintenance of relevant liver functions ex vivo requires models in which the cells exhibit an in vivo‐like phenotype, often achieved by reconstitution of appropriate cellular interactions. Multiple different models have
V. M. Lauschke +3 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel +4 more
wiley +1 more source
Recreational drug toxicity [PDF]
Clinical Medicine, 2008 Simon H. L. Thomas +2 more
openaire +3 more sources
A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice
Science Translational Medicine, 2012 An in vitro model of human pulmonary edema predicts drug toxicity and efficacy previously observed in humans. Pulmonary Edema-on-a-Chip Drug testing in animal models is time-consuming, costly, and often does not accurately predict the adverse effects in ...
D. Huh +8 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source