Results 11 to 20 of about 5,373,155 (364)
Drug Toxicity Evaluation Based on Organ-on-a-chip Technology: A Review
Micromachines, 2020 Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a-chip is the ability to integrate drug metabolism and drug toxic processes in
Ye Cong +9 more
doaj +2 more sources
Mechanisms underlying lipid emulsion resuscitation for drug toxicity: a narrative review. [PDF]
Korean J Anesthesiol, 2023 Currently, lipid emulsion (LE) is widely used to treat local anesthetic systemic toxicity (LAST). LE also ameliorates intractable cardiovascular collapse caused by lipid-soluble non-local anesthetic drug toxicity.
Lee SH, Sohn JT.
europepmc +2 more sources
Drug toxicity assessment: cell proliferation versus cell death. [PDF]
Cell Death Discov, 2022 Analysis of the toxicity of chemotherapeutic drugs is one of the main tasks of clinical pharmacology. Decreased viability of tumor cells may reflect two important physiological processes, namely the arrest of proliferation associated with disturbances in
Sazonova EV +3 more
europepmc +2 more sources
Drug toxicity in the proximal tubule: new models, methods and mechanisms. [PDF]
Pediatr Nephrol, 2022 The proximal tubule (PT) reabsorbs most of the glomerular filtrate and plays an important role in the uptake, metabolism and excretion of xenobiotics. Some therapeutic drugs are harmful to the PT, and resulting nephrotoxicity is thought to be responsible
Hall AM, Trepiccione F, Unwin RJ.
europepmc +2 more sources
Thiopurines' Metabolites and Drug Toxicity: A Meta-Analysis. [PDF]
J Clin Med, 2020 Many questions remain unanswered regarding therapeutic drug monitoring (TDM) utility with thiopurines. This study aims to establish a relationship between thiopurines’ metabolites and drug toxicity.
Sousa P +7 more
europepmc +2 more sources
Beneficial effects of α-lipoic acid in diabetes- and drug- induced liver injury [PDF]
Archives of Biological Sciences, 2018 This review summarizes the effects of α-lipoic acid (LA) on liver damage and complications in diabetes and drug toxicity. LA is a naturally occurring dithiol compound that plays an essential role in mitochondrial metabolism in its protein-bound form.
Uskoković Aleksandra +6 more
doaj +1 more source
Frontiers in Immunology, 2021 Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative therapy for patients with hematological malignancies. Acute Graft versus host diseases (GVHD) is a major immune mediated side effect of allo-HCT that can affect the central nervous ...
Janaki Manoja Vinnakota +3 more
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Clinical and Translational Science, 2020 Liver microphysiological systems (MPSs) are promising models for predicting hepatic drug effects. Yet, after a decade since their introduction, MPSs are not routinely used in drug development due to lack of criteria for ensuring reproducibility of ...
Andrés Rubiano +14 more
semanticscholar +1 more source
Genomics and Drug Toxicity [PDF]
Science, 2004 A s genomics has revolutionized the study of biology, so has it affected how drugs are discovered. Pharmaceutical companies have also realized another major application: how drugs are assessed for safety. The analysis of gene expression profiles is now actively used alongside conventional toxicological assays to assess drug safety.
Thomas Papoian, Peter G. Lord
openaire +3 more sources
Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity
Frontiers in Cell and Developmental Biology, 2022 Nrf2 and NF-κB are important regulators of the response to oxidative stress and inflammation in the body. Previous pharmacological and genetic studies have confirmed crosstalk between the two.
Wen Gao +7 more
semanticscholar +1 more source