Results 11 to 20 of about 6,137,811 (297)

Drug Toxicity Evaluation Based on Organ-on-a-chip Technology: A Review

Micromachines, 2020
Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a-chip is the ability to integrate drug metabolism and drug toxic processes in
Ye Cong, Xiahe Han, Youping Wang, Zongzheng Chen, Yao Lu, Tingjiao Liu, Zhengzhi Wu, Yu Jin, Yong Luo, Xiuli Zhang   +9 more
doaj   +2 more sources

Mechanisms underlying lipid emulsion resuscitation for drug toxicity: a narrative review. [PDF]

Korean J Anesthesiol, 2023
Currently, lipid emulsion (LE) is widely used to treat local anesthetic systemic toxicity (LAST). LE also ameliorates intractable cardiovascular collapse caused by lipid-soluble non-local anesthetic drug toxicity.
Lee SH, Sohn JT.
europepmc   +2 more sources

Drug toxicity assessment: cell proliferation versus cell death. [PDF]

Cell Death Discov, 2022
Analysis of the toxicity of chemotherapeutic drugs is one of the main tasks of clinical pharmacology. Decreased viability of tumor cells may reflect two important physiological processes, namely the arrest of proliferation associated with disturbances in
Sazonova EV, Chesnokov MS, Zhivotovsky B, Kopeina GS.   +3 more
europepmc   +2 more sources

Artificial Intelligence-Driven Drug Toxicity Prediction: Advances, Challenges, and Future Directions. [PDF]

Toxics
Drug toxicity prediction plays a crucial role in the drug research and development process, ensuring clinical drug safety. However, traditional methods are hampered by high cost, low throughput, and uncertainty of cross-species extrapolation, which has ...
Zhang R, Wen H, Lin Z, Li B, Zhou X.
europepmc   +2 more sources

Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening. [PDF]

Micromachines (Basel), 2022
Microfluidic technology has been highly useful in nanovolume sample preparation, separation, synthesis, purification, detection and assay, which are advantageous in drug development.
Zhao P, Wang J, Chen C, Wang J, Liu G, Nandakumar K, Li Y, Wang L.   +7 more
europepmc   +2 more sources

Drug toxicity in the proximal tubule: new models, methods and mechanisms

Pediatric nephrology (Berlin, West), 2021
The proximal tubule (PT) reabsorbs most of the glomerular filtrate and plays an important role in the uptake, metabolism and excretion of xenobiotics. Some therapeutic drugs are harmful to the PT, and resulting nephrotoxicity is thought to be responsible
A. Hall, F. Trepiccione, R. Unwin
semanticscholar   +1 more source

Variation of drugs involved in acute drug toxicity presentations based on age and sex: an epidemiological approach based on European emergency departments

Clinical toxicology, 2021
Objective To analyse the relative percentage of acute recreational drug toxicity emergency department (ED) presentations involving the main drug groups according to age and sex and investigate different patterns based on sex and age strata.
Ò. Miró, W. Waring, P. Dargan, D. Wood, A. Dines, C. Yates, I. Giraudon, A. Moughty, N. O'connor, F. Heyerdahl, K. Hovda, O. M. Vallersnes, Raido Paasma, K. Põld, G. Jürgens, B. Mégarbane, J. S. Anand, E. Liakoni, M. Liechti, F. Eyer, S. Zacharov, B. Caganova, Jeffrey Bonnici, J. Radenkova-Saeva, M. Galicia   +24 more
semanticscholar   +1 more source

Rhabdomyolysis related to acute recreational drug toxicity—A Euro-DEN study

PLoS ONE, 2021
Background This study was conducted to retrospectively assess the relationships between: rhabdomyolysis (quantified by creatine kinase (CK) activity) and kidney injury (quantified by serum creatinine concentration), sex, age, body temperature on ...
W. Waldman, P. Kabata, A. Dines, D. Wood, C. Yates, F. Heyerdahl, K. Hovda, I. Giraudon, P. Dargan, J. Sein Anand   +9 more
semanticscholar   +1 more source

Thiopurines' Metabolites and Drug Toxicity: A Meta-Analysis. [PDF]

J Clin Med, 2020
Many questions remain unanswered regarding therapeutic drug monitoring (TDM) utility with thiopurines. This study aims to establish a relationship between thiopurines’ metabolites and drug toxicity.
Sousa P, Estevinho MM, Dias CC, Ministro P, Kopylov U, Danese S, Peyrin-Biroulet L, Magro F.   +7 more
europepmc   +2 more sources

Doxorubicin-Based Hybrid Compounds as Potential Anticancer Agents: A Review

Molecules, 2022
The scarcity of novel and effective therapeutics for the treatment of cancer is a pressing and alarming issue that needs to be prioritized. The number of cancer cases and deaths are increasing at a rapid rate worldwide.
Sijongesonke Peter, Sibusiso Alven, Rejoice Bethusile Maseko, Blessing Atim Aderibigbe   +3 more
doaj   +1 more source