Results 231 to 240 of about 6,137,811 (297)
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Journal of Chemical Information and Modeling, 2023
Toxicity prediction is a critical step in the drug discovery process that helps identify and prioritize compounds with the greatest potential for safe and effective use in humans, while also reducing the risk of costly late-stage failures.
Thi Tuyet Van Tran +3 more
semanticscholar +1 more source
Toxicity prediction is a critical step in the drug discovery process that helps identify and prioritize compounds with the greatest potential for safe and effective use in humans, while also reducing the risk of costly late-stage failures.
Thi Tuyet Van Tran +3 more
semanticscholar +1 more source
ACS Applied Materials and Interfaces, 2022
Bioengineering an in vitro liver model recapitulating the native liver microarchitecture consisting of parenchymal and non-parenchymal cells is crucial in achieving cellular crosstalk and hepatic metabolic functions for accurate hepatotoxicity prediction.
G. Janani +3 more
semanticscholar +1 more source
Bioengineering an in vitro liver model recapitulating the native liver microarchitecture consisting of parenchymal and non-parenchymal cells is crucial in achieving cellular crosstalk and hepatic metabolic functions for accurate hepatotoxicity prediction.
G. Janani +3 more
semanticscholar +1 more source
Connecting the dots: Targeting the microbiome in drug toxicity
Medicinal research reviews (Print), 2021The gut microbiota has a vast influence on human health and its role in initiating, aggravating, or ameliorating diseases is beginning to emerge. Recently, its contribution to heterogeneous toxicological responses is also gaining attention, especially in
Yusha Luo, Tingting Zhou
semanticscholar +1 more source
Critical Care Clinics, 2021
Managing unstable poisoned patients is often associated with clinician cognitive overload. This article summarizes the mechanisms of toxicity; clinical presentations; and the current evidence available for the treatment of cardiovascular drug toxicity due to calcium channel blockers, beta-blockers, cardiac glycosides, and sodium channel blockers.
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Managing unstable poisoned patients is often associated with clinician cognitive overload. This article summarizes the mechanisms of toxicity; clinical presentations; and the current evidence available for the treatment of cardiovascular drug toxicity due to calcium channel blockers, beta-blockers, cardiac glycosides, and sodium channel blockers.
openaire +2 more sources
An Overview of Machine Learning and Big Data for Drug Toxicity Evaluation.
Chemical Research in Toxicology, 2020Drug toxicity evaluation is an essential process of drug development as it is reportedly responsible for the attrition of approximately 30% of drug candidates.
Andy H. Vo +4 more
semanticscholar +1 more source
Definitions, 2002
of inappropriate antidiuresis and renal salt wasting syndrome, but his hypertonic hyponatraemia indicated mannitol-induced translocational hyponatraemia.Granular, epithelial casts, glycosuria and blood glucose level (144 mg/dL), indicated tubular injury ...
C. Taniguchi +4 more
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of inappropriate antidiuresis and renal salt wasting syndrome, but his hypertonic hyponatraemia indicated mannitol-induced translocational hyponatraemia.Granular, epithelial casts, glycosuria and blood glucose level (144 mg/dL), indicated tubular injury ...
C. Taniguchi +4 more
openaire +2 more sources
Applications of Machine Learning Methods in Drug Toxicity Prediction.
Current Topics in Medicinal Chemistry, 2018Toxicity evaluation is an important part of the preclinical safety assessment of new drugs, which is directly related to human health and the fate of drugs. It is of importance to study how to evaluate drug toxicity accurately and economically.
Li Zhang +6 more
semanticscholar +1 more source
2018
Drug-induced retinal toxicity can occur from the use of systemic, intravitreal, or topical medications. Despite the presence of the blood-ocular barrier, the retina is vulnerable to toxic effects of systemic medications leading to dysfunction and retinal degeneration. These toxicities can be categorized as damage to the retinal pigment epithelium (RPE)
Stephen H, Tsang, Tarun, Sharma
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Drug-induced retinal toxicity can occur from the use of systemic, intravitreal, or topical medications. Despite the presence of the blood-ocular barrier, the retina is vulnerable to toxic effects of systemic medications leading to dysfunction and retinal degeneration. These toxicities can be categorized as damage to the retinal pigment epithelium (RPE)
Stephen H, Tsang, Tarun, Sharma
openaire +2 more sources
Drug Interactions and Toxicity
Archives of Internal Medicine, 1980To the Editor. —The article by Chapron et al, in theArchives(139:363-365, 1979), describing the potential impact of hepatic enzyme stimulants on quinidine sulfate metabolism, nicely illustrates the importance of evaluating all of the individual patient variables when assessing a therapeutically relevant drug interaction. The major points of their case
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