Results 241 to 250 of about 6,137,811 (297)

Drug-Induced Mitochondrial Toxicity

Drug Safety, 2016
The mitochondrial respiratory chain (MRC) and ATP synthase (complex V) play an essential role in cellular energy production by the process of oxidative phosphorylation. In addition to inborn errors of metabolism, as well as secondary causes from disease pathophysiology, an impairment of oxidative phosphorylation can result from drug toxicity.
Iain P, Hargreaves, Mesfer, Al Shahrani, Luke, Wainwright, Simon J R, Heales   +3 more
openaire   +2 more sources

Drug-induced mitochondrial toxicity

Expert Opinion on Drug Metabolism & Toxicology, 2005
Mitochondria play a critical role in generating most of the cell's energy as ATP. They are also involved in other metabolic processes such as urea generation, haem synthesis and fatty acid beta-oxidation. Disruption of mitochondrial function by drugs can result in cell death by necrosis or can signal cell death by apoptosis (e.g., following cytochrome ...
Katie, Chan, Don, Truong, Nandita, Shangari, Peter J, O'Brien   +3 more
openaire   +2 more sources

Prediction of drug toxicity

Il Farmaco, 2001
The use of computer-aided methods to predict the toxicity of drugs is described. These methods can assist in the identification of toxic compounds early in the drug development process. Thus, there is potential for these methods to be combined with combinatorial synthesis and library design.
openaire   +2 more sources

Pharmacogenomics and Drug Toxicity

New England Journal of Medicine, 2008
In the United States alone, it is estimated that adverse drug reactions affect nearly 2 million patients and kill about 100,000 people each year.1 Adverse drug reactions are often classified into two groups. The first group can be explained by the mode of action of the therapeutic drug.
openaire   +2 more sources

Drug-Induced Mitochondrial Toxicity

2018
Mitochondrial dysfunction can be a major mechanism whereby different drugs can induce adverse effects affecting different tissues such as liver, heart and skeletal muscle. In the most severe cases, drug-induced mitochondrial dysfunction can require a hospitalization, or lead to the death of the patient.
Massart, J., Borgne-Sanchez, A., Fromenty, B.   +2 more
openaire   +2 more sources

Toxic Drugs

New England Journal of Medicine, 1964
C W, MCMILLAN, W R, PURCELL
openaire   +2 more sources

Drug Toxicity.

Canadian Medical Association journal, 2010
Nicola Simola, Micaela Morelli, Tooru Mizuno, Suzanne H. Mitchell, Harriet de Wit, H. Valerie Curran, Celia J. A. Morgan, Stephan G. Anagnostaras, Jennifer R Sage, Stephanie A Carmack, Lawrence H. Price, Grasielle C Kincheski, Leandro J Bertoglio, Antonio Padua Carobrez, Andrea Bari, Roshan Cools, Yogita Chudasama, Stefan Leucht, Yogita Chudasama, William Breitbart, Yesne Alici, Karl Mann, Falk Kiefer, Yesne Alici, William Breitbart, Michael M Morgan, M J Christie, Istvan Bitter, Eileen M. Joyce, Jonathan P Roiser, Darren R Christensen, Warren K. Bickel, Kenneth J. Rhodes, Peter Paul De Deyn, Debby Van Dam, Darrel J. Pemberton, Johannes Mosbacher, Thomas Steckler, Alyson J Bond, Alex Hofer, Stefan Leucht, Daniel Bertrand, Hans Rollema, Raymond S Hurst, Irwin Lucki, Fadi T. Maalouf, David A. Brent, David A. Brent, Fadi Maalouf, Alex Hofer, Daniel Bertrand, Hans Rollema, Raymond S Hurst, Huaiyu Yang, George I. Papakostas, Andrew Young, Gabriele Fischer, Annemarie Unger, Linda P Spear, Linda P Spear, Mohammed Shoaib, Emma Childs, Britta Hahn, Peter Boeijinga, Martine Cador, David S Tait, Verity J. Brown, Martine Cador, David Baldwin, Yavin Shaham, Sunila G Nair, Yavin Shaham, Sunila G Nair, Matthew I Palmatier, Rick A Bevins, Peter Riederer, Siegfried Hoyer, Mark Geyer, Anthony Absalom, David Menon, Joseph Zohar, Stephen C Fowler, James Winslow, Kim Wolff, Bankole A. Johnson, Martina de Zwaan, Alyson J Bond, Angela Roberts, Anthony R Isles, Lawrence S. Wilkinson, Anthony R Isles, Lawrence S. Wilkinson, Rosa M M de Almeida, Klaus A. Miczek, Eric Nestler, Naheed (Max) Mirza, Bankole A Johnson, Joseph H Friedman, István Bitter, Michael Minzenberg, Lawrence H. Price, Ashwini Padhi, Naomi Fineberg, Michael M Morgan, MacDonald J. Christie, Lawrence H. Price, Joris C. Verster, Bernard Le Foll, Marilyn E Carroll, Peter A Santi, Ronald F Mucha, Ian P. Stolerman, Richard W Foltin, Michael Minzenberg, Christoph Hiemke, Luis Stinus, Stéphanie Caillé, Martine Cador, Yavin Shaham, John R Mantsch, Ronald F Mucha, Kim Wolff, Anthony L. Riley, Steve Kohut, Brian E. Leonard, Joseph Zohar, R. Andrew Chambers, Gail Winger, Mei-Chuan Ko, James H Woods, Huaiyu Yang, George I. Papakostas, Michael M Morgan, MacDonald J. Christie, Seiya Miyamoto, Thomas R. E. Barnes, Kieran O’Malley, Luis Stinus, Stéphanie Caillé, Martine Cador, David J. Hellerstein, Thomas R. E. Barnes   +141 more
openaire   +3 more sources

Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies

Ca-A Cancer Journal for Clinicians, 2022
Paolo Tarantino, Roberto Carmagnani Pestana, Shanu Modi   +2 more
exaly  

[Drug-induced toxic hepatitis].

La Clinica terapeutica, 1994
The case is described of a woman with drug hepatotoxicity, who was a psychiatric patient. The case is reported because the diagnosis occurred by a "praecoxfeeling", in fact physician's intuition is a personal structure which is born from same external incitements instead of other. The diagnosis was confirmed by clinical tests and by subsequent clinical
Suppa, M, Bruni, P, Colzi, M, Diaczenko, A M, Scarpellini, M G, Tullo, M G, Aguglia, F   +6 more
openaire   +2 more sources

Cancer epigenetics in clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Veronica Davalos, Manel Esteller
exaly