Results 21 to 30 of about 5,373,155 (364)
Arabian Journal of Chemistry, 2018 A new method for the synthesis of 1,3-disubstituted benzimidazole derivatives was developed using aza-Michael addition. The target compounds were synthesized in good yields and purity and tested on isolated hepatocytes for their toxicity and antioxidant ...
Neda O. Anastassova +7 more
doaj +1 more source
12. Toxicity of antirheumatic drugs [PDF]
Medical Journal of Australia, 1997 Pharmacological treatments can have a major impact on the outcome of rheumatic diseases. To achieve the best results, individual treatment regimens comprising analgesic agents, non-steroidal anti-inflammatory drugs and disease-modifying antirheumatic drugs are used.
Lehmann, T., Day, R. O., Brooks, P. M.
openaire +3 more sources
Microbiology Spectrum, 2023 With the application of bedaquiline (Bdq), the success rate of multidrug-resistant tuberculosis (MDR-TB) treatment has been significantly improved; however, the cardiac safety of the patients during treatment cannot be ignored. Hence, this study compared
Rong Li +6 more
doaj +1 more source
Risk factors profile for liver damage in cardiac inpatients [PDF]
Vojnosanitetski Pregled, 2020 Background/Aim. Liver damage, with potentially serious consequences, is not uncommon in hospitalized cardiac patients. The aim of our study was to determine the risk factor profile for liver damage in patients hospitalized from a deterioration of their ...
Jovanović Jovan +10 more
doaj +1 more source
Pharmaceuticals, 2023 Uveal melanoma (UM) is a rare malignant cancer of the eye, with up to 50% of patients dying from metastasis, for which no effective treatment is available.
Jie Yin +9 more
doaj +1 more source
Pharmaceutics, 2022 Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but also contributes to the high morbidity and mortality rates of cardiovascular diseases. Comprehensive testing for proarrhythmic risks of drugs has been applied in
Xiaoli Tang +3 more
doaj +1 more source
A Rare Cause of Drug-Induced Pancytopenia: Trimethoprim–Sulfamethoxazole-Induced Pancytopenia
Clinics and Practice, 2021 Pancytopenia is a decrease across cellular hematological lines. Many different etiologies can cause this clinical picture including viral and bacterial infections, chemicals, malignancy, and medications.
Khalid Sawalha +2 more
doaj +1 more source
Principled Drug-Drug Interaction Terms for Bayesian Logistic Regression Models of Drug Safety in Oncology Phase I Combination Trials [PDF]
arXiv, 2023 In Oncology, trials evaluating drug combinations are becoming more common. While combination therapies bring the potential for greater efficacy, they also create unique challenges for ensuring drug safety. In Phase-I dose escalation trials of drug combinations, model-based approaches enable efficient use of information gathered, but the models need to ...
arxiv
Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling.
ACS Chemical Biology, 2019 It is increasingly clear that interindividual variability in human gut microbial composition contributes to differential drug responses. For example, gastrointestinal (GI) toxicity is not observed in all patients treated with the anticancer drug ...
Parth B Jariwala +12 more
semanticscholar +1 more source
Modifying and Integrating in vitro and ex vivo Respiratory Models for Inhalation Drug Screening
Frontiers in Bioengineering and Biotechnology, 2020 For the past 50 years, the route of inhalation has been utilized to administer therapies to treat a variety of respiratory and pulmonary diseases. When compared with other drug administration routes, inhalation offers a targeted, non-invasive approach to
Aylin Cidem +6 more
doaj +1 more source