Results 291 to 300 of about 5,373,155 (364)

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, EarlyView.
H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie, Samin Abbaszadeh, Kik Marais, Vahideh Nosrati‐Siahmazgi, Saman Rezaei, Bo Xiao, Kamal Dua, Hélder A. Santos, Mohammad‐Ali Shahbazi   +8 more
wiley   +1 more source

Strategic proposals for avoiding toxic interactions with drugs for clinical use during development and after marketing of a new drug. Proposals for designing non-clinical and clinical studies. Is the non-clinical study useful?

, 1996
Naok̆i Ozawa
openalex   +2 more sources

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

THE STUDY OF XENOBIOTIC-METABOLIZING ENZYMES AND THEIR ROLE IN DRUG METABOLISM AND TOXICITY USING TARGETED GENE DISRUPTION

, 1998
Frank J. Gonzalez
openalex   +2 more sources

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

A 13-WEEK ORAL REPEATED DOSE TOXICITY STUDY OF (±)-4-DIETHYLAMINO-1, 1-DIMETHYLBUT-2-YN-1-YL 2-CYCLOHEXYL-2-HYDROXY 2-PHENYLACETATE MONOHYDROCHLORIDE MONOHYDRATE(NS-21), A NOVEL DRUG FOR URINARY FREQUENCY AND INCONTINENCE, IN DOGS FOLLOWED BY A 5-WEEK RECOVERY TEST

, 1997
Masaru YOSHIDA, Takaaki OKA, Takeharu TAWARATANI, Seitaro ISHIBASHI, Motokuni NAKAZAWA, Eita KITAYAMA, Takahiro ADACHI, Keiko IWAKURA, Nobuyoshi SUMI   +8 more
openalex   +2 more sources

Integration of Perovskite/Low‐Dimensional Material Heterostructures for Optoelectronics and Artificial Visual Systems

Advanced Functional Materials, EarlyView.
Heterojunctions combining halide perovskites with low‐dimensional materials enhance optoelectronic devices by enabling precise charge control and improving efficiency, stability, and speed. These synergies advance flexible electronics, wearable sensors, and neuromorphic computing, mimicking biological vision for real‐time image analysis and intelligent
Yu‐Jin Du, Junjie Yang, Ziyu Lv, Yongbiao Zhai, Zezhuang Yi, Yuhui Xie, Ming‐Lin Zheng, Xiangyu Ma, Guodong Gong, Yan Wang, Ye Zhou, Su‐Ting Han   +11 more
wiley   +1 more source

REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF (±)-4-DIETHYLAMINO-1, 1-DIMETHYLBUT-2-YN-1-YL 2-CYCLOHEXYL-2-HYDROXY-2-PHENYLACETATE MONOHYDROCHLORIDE MONOHYDRATE(NS-21), A NOVEL DRUG FOR URINARY FREQUENCY AND INCONTINENCE (2) Teratogenicity Study in Rats by Oral Administration

, 1997
James L. SCHARDEIN, Raymond G. YORK, Hironori NINOMIYA, Masataka Watanabe, Nobuyoshi SUMI   +4 more
openalex   +2 more sources

Engagement of people with lived and living experience in the editorial process: reflections on the special series on the unregulated drug toxicity crisis in Canada. [PDF]

Health Promot Chronic Dis Prev Can
Young P, Burmeister C, Slaunwhite A, Palis H.   +3 more
europepmc   +1 more source