Results 311 to 320 of about 5,373,155 (364)

Radiation‐Resistant Bacteria Deinococcus radiodurans‐Derived Extracellular Vesicles as Potential Radioprotectors

Advanced Healthcare Materials, EarlyView.
Deinococcus radiodurans‐derived extracellular vesicles (R1‐EVs) provide radioprotection against total‐body irradiation‐induced acute radiation syndrome in mice. R1‐EVs mitigate oxidative damage by scavenging free radicals, promoting intestinal repair, enhancing hematopoietic function, and modulating immune responses. This study highlights the potential
Jeong Moo Han, Godfrey Mwiti, Seo‐Joon Yeom, Jaeyoon Lim, Woo Sik Kim, Sangyong Lim, Seung‐Taik Lim, Eui‐Baek Byun   +7 more
wiley   +1 more source

Supercritical Fluid‐Processed Multifunctional Hybrid Decellularized Extracellular Matrix with Chitosan Hydrogel for Improving Photoaged Dermis Microenvironment

Advanced Healthcare Materials, EarlyView.
These findings advance tissue repair by offering a multifunctional filler that improves large‐scale volume retention, elasticity, and support for vascularized tissue growth. The decellularized extracellular matrix (dECM)‐based material provides low injection force and minimizes swelling, ensuring sustained volume. Combining CMC with supercritical fluid‐
Seol‐Ha Jeong, Jae Jun Kang, Ki‐Myo Kim, Mi hyun lee, Misun Cha, Su Hee Kim, Ji‐Ung Park   +6 more
wiley   +1 more source

Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone

Advanced Healthcare Materials, EarlyView.
This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li, Andi Dian Permana, Juan Domínguez‐Robles, Muh Nur Amir, Habibie Habibie, Qonita Kurnia Anjani, Li Zhao, Natalia Moreno‐Castellanos, Ryan F Donnelly, Eneko Larrañeta   +9 more
wiley   +1 more source

Multiscale Thermal Analysis of Gold Nanostars in 3D Tumor Spheroids: Integrating Cellular‐Level Photothermal Effects and Nanothermometry via X‐Ray Spectroscopy

Advanced Healthcare Materials, EarlyView.
This study investigates nanoscale temperatures generated by photoexcited gold nanostars and their correlation with microscale thermal damage at the cellular level. Using X‐ray absorption spectroscopy and confocal microscopy in 3D cancer spheroids, it assesses localized heating effects and examines tumor cell structure and integrity, offering insights ...
Rosalía López‐Méndez, Anastasiia Dubrova, Javier Reguera, Rául Magro, Fátima Esteban‐Betegón, Ana Parente, Miguel Ángel García, Julio Camarero, Emiliano Fonda, Claire Wilhelm, Álvaro Muñoz‐Noval, Ana Espinosa   +11 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Artificial Intelligence in Drug Toxicity Prediction: Recent Advances, Challenges, and Future Perspectives

Journal of Chemical Information and Modeling, 2023
Toxicity prediction is a critical step in the drug discovery process that helps identify and prioritize compounds with the greatest potential for safe and effective use in humans, while also reducing the risk of costly late-stage failures.
Thi Tuyet Van Tran, Agung Surya Wibowo, Hilal Tayara, K. Chong   +3 more
semanticscholar   +1 more source

Nanocarrier-Based Tumor-Targeting Drug Delivery Systems for Hepatocellular Carcinoma Treatments: Enhanced Therapeutic Efficacy and Reduced Drug Toxicity.

Journal of Biomedical Nanotechnology, 2022
Hepatocellular carcinoma (HCC), due to the lack of efficient diagnostic methods and short of available treatments, becomes the third main cause of cancer deaths. Novel treatments for HCCs are thus in great need.
Tian Tian, J. Ruan, Jia Zhang, Chun‐Xia Zhao, Dong Chen, Jianzhen Shan   +5 more
semanticscholar   +1 more source

Connecting the dots: Targeting the microbiome in drug toxicity

Medicinal research reviews (Print), 2021
The gut microbiota has a vast influence on human health and its role in initiating, aggravating, or ameliorating diseases is beginning to emerge. Recently, its contribution to heterogeneous toxicological responses is also gaining attention, especially in
Yusha Luo, Tingting Zhou
semanticscholar   +1 more source

An Overview of Machine Learning and Big Data for Drug Toxicity Evaluation.

Chemical Research in Toxicology, 2020
Drug toxicity evaluation is an essential process of drug development as it is reportedly responsible for the attrition of approximately 30% of drug candidates.
Andy H. Vo, T. V. Van Vleet, R. Gupta, M. Liguori, Mohan S. Rao   +4 more
semanticscholar   +1 more source