Results 321 to 330 of about 5,373,155 (364)
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Critical Care Clinics, 2021
Managing unstable poisoned patients is often associated with clinician cognitive overload. This article summarizes the mechanisms of toxicity; clinical presentations; and the current evidence available for the treatment of cardiovascular drug toxicity due to calcium channel blockers, beta-blockers, cardiac glycosides, and sodium channel blockers.
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Managing unstable poisoned patients is often associated with clinician cognitive overload. This article summarizes the mechanisms of toxicity; clinical presentations; and the current evidence available for the treatment of cardiovascular drug toxicity due to calcium channel blockers, beta-blockers, cardiac glycosides, and sodium channel blockers.
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Definitions, 2020
Physicians prescribe drugs to prevent or treat disease. Those same drugs can be toxic to certain patients, however, because of genetic predisposition, nonselective action, or inappropriate use or administration of the drug.
C. Taniguchi +4 more
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Physicians prescribe drugs to prevent or treat disease. Those same drugs can be toxic to certain patients, however, because of genetic predisposition, nonselective action, or inappropriate use or administration of the drug.
C. Taniguchi +4 more
semanticscholar +1 more source
Drug Transporters in Drug Efficacy and Toxicity [PDF]
Annual Review of Pharmacology and Toxicology, 2012 Drug transporters are now widely acknowledged as important determinants governing drug absorption, excretion, and, in many cases, extent of drug entry into target organs. There is also a greater appreciation that altered drug transporter function, whether due to genetic polymorphisms, drug-drug interactions, or environmental factors such as dietary ...
J J Yang +3 more
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Neonatology, 2004
The incidence of adverse drug reactions in neonates is thought to be at least 10%. The physiology of the newborn infant is different to that of both paediatric patients and adults. This therefore predisposes to certain types of drug toxicity, which are described below.
John McIntyre, Imti Choonara
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The incidence of adverse drug reactions in neonates is thought to be at least 10%. The physiology of the newborn infant is different to that of both paediatric patients and adults. This therefore predisposes to certain types of drug toxicity, which are described below.
John McIntyre, Imti Choonara
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Applications of Machine Learning Methods in Drug Toxicity Prediction.
Current Topics in Medicinal Chemistry, 2018Toxicity evaluation is an important part of the preclinical safety assessment of new drugs, which is directly related to human health and the fate of drugs. It is of importance to study how to evaluate drug toxicity accurately and economically.
Li Zhang +6 more
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Drug Interactions and Toxicity
Archives of Internal Medicine, 1980To the Editor. —The article by Chapron et al, in theArchives(139:363-365, 1979), describing the potential impact of hepatic enzyme stimulants on quinidine sulfate metabolism, nicely illustrates the importance of evaluating all of the individual patient variables when assessing a therapeutically relevant drug interaction. The major points of their case
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Microengineered Bioartificial Liver Chip for Drug Toxicity Screening
, 2018Microfluidic 3D cell culture is a promising technology for the screening of drug toxicity profiles. In this study, a bioartificial liver consisting of a surface‐engineered microfluidic silicon chip with microtrenches mimicking hepatic sinusoids is shown ...
B. Delalat +9 more
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Il Farmaco, 2001
The use of computer-aided methods to predict the toxicity of drugs is described. These methods can assist in the identification of toxic compounds early in the drug development process. Thus, there is potential for these methods to be combined with combinatorial synthesis and library design.
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The use of computer-aided methods to predict the toxicity of drugs is described. These methods can assist in the identification of toxic compounds early in the drug development process. Thus, there is potential for these methods to be combined with combinatorial synthesis and library design.
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Drug metabolism and drug toxicity
InflammoPharmacology, 2001Adverse drug reactions are a major problem for both health care providers and the pharmaceutical industry. They are a common and significant cause of morbidity and mortality and occasionally result in the withdrawal of an otherwise valuable therapeutic agent.
Neil R. Kitteringham +3 more
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Pharmacogenomics and Drug Toxicity
New England Journal of Medicine, 2008In the United States alone, it is estimated that adverse drug reactions affect nearly 2 million patients and kill about 100,000 people each year.1 Adverse drug reactions are often classified into two groups. The first group can be explained by the mode of action of the therapeutic drug.
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