Results 31 to 40 of about 5,373,155 (364)
Dose Selection Balancing Efficacy and Toxicity Using Bayesian Model Averaging [PDF]
arXiv, 2023 Successful pharmaceutical drug development requires finding correct doses that provide an optimum balance between efficacy and toxicity. Competing responses to dose such as efficacy and toxicity often will increase with dose, and it is important to identify a range of doses to provide an acceptable efficacy response (minimum effective dose) while not ...
arxiv
ALNSynergy: a graph convolutional network with multi-representation alignment for drug synergy prediction [PDF]
arXiv, 2023 Drug combination refers to the use of two or more drugs to treat a specific disease at the same time. It is currently the mainstream way to treat complex diseases. Compared with single drugs, drug combinations have better efficacy and can better inhibit toxicity and drug resistance.
arxiv
Allo-network drugs: harnessing allostery in cellular networks [PDF]
Trends in Pharmacological Sciences (2011) 32, 686-693, 2011 Allosteric drugs are increasingly used because they produce fewer side effects. Allosteric signal propagation does not stop at the 'end' of a protein, but may be dynamically transmitted across the cell. Here, we propose that the concept of allosteric drugs can be broadened to allo-network drugs, whose effects can propagate either within a protein, or ...
arxiv +1 more source
Antimalarial Drug Toxicity [PDF]
Drug Safety, 2004 Malaria, caused mostly by Plasmodium falciparum and P. vivax, remains one of the most important infectious diseases in the world. Antimalarial drug toxicity is one side of the risk-benefit equation and is viewed differently depending upon whether the clinical indication for drug administration is malaria treatment or prophylaxis.
Nicholas J. White +2 more
openaire +3 more sources
Drug delivery with carbon nanotubes for in vivo cancer treatment [PDF]
Cancer Res. 68 (2008) 6652-6660, 2008 Chemically functionalized single-walled carbon nanotubes (SWNTs) have shown promise in tumor targeted accumulation in mice and exhibit biocompatibility, excretion and little toxicity. Here, we demonstrate in-vivo SWNT drug delivery for tumor suppression in mice.
arxiv +1 more source
Online Analysis of Drug Toxicity to Cells with Shear Stress on an Integrated Microfluidic Chip.
ACS Sensors, 2019 Mechanical stimulation, especially fluid shear stress (FSS), is essential for a cell to regulate regular behaviors. A high-throughput platform to provide varying FSS for cell research is desperately required for better mimicking of the complex fluidic ...
Shuo Feng +4 more
semanticscholar +1 more source
Drug Metabolism And Disposition, 2022 The market for large molecule biologic drugs has grown rapidly, including antisense oligonucleotide (ASO) drugs. ASO drugs work as single-stranded synthetic oligonucleotides that reduce production or alter functions of disease-causing proteins through ...
Feryal Alhamadani +7 more
semanticscholar +1 more source
Clinical and epidemiological evaluation of patients with colorectal cancer from Rio Grande do Sul
Journal of Coloproctology, 2012 Colorectal cancer has a high incidence in Brazil, with the South and Southeast regions presenting the largest number of cases. OBJECTIVE: Identify the epidemiological characteristics and the regimens used as first-line treatment of patients with ...
Michelle Fraga Eisenhardt +8 more
doaj +1 more source
Quantifying the Consequences of Catheter Steerability Limitations on Targeted Drug Delivery [PDF]
arXiv, 2021 In this work, we virtually study the intra-arterial targeted drug delivery. Specifically, this work models and quantifies the uncertainties associated with catheter steerability limitations. We classify catheter's limited steerability into two types, i.e., zero steerability, and wall pressing steerability.
arxiv
Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022 Abstract Purpose A set of treatment planning strategies were designed and retrospectively implemented for locally advanced, non‐small cell lung cancer (NSCLC) patients in order to minimize cardiac dose without compromising target coverage goals. Methods Retrospective analysis was performed for 20 NSCLC patients prescribed to 60–66 Gy that received a ...
Joshua P. Kim +5 more
wiley +1 more source