Preclinical evaluation of local prolonged release of paclitaxel from gelatin microspheres for the prevention of recurrence of peritoneal carcinomatosis in advanced ovarian cancer [PDF]
, 2019 Patients with advanced ovarian cancer develop recurrence despite initial treatment response to standard treatment of surgery and intravenous/intraperitoneal (IP) chemotherapy, partly due to a limited peritoneal exposure time of chemotherapeutics ...
Ceelen, Wim +7 more
core +2 more sources
Frontiers in Pharmacology, 2022 Aims: To develop, optimize, and validate a novel model using alanine aminotransferase (ALT) and total bilirubin (TB) dynamic evolution patterns in predicting acute liver failure (ALF) in drug-induced liver injury (DILI) patients.Methods: The demographics,
Ruiyuan Yang +18 more
doaj +1 more source
Case Report: Allergic Bronchopulmonary Aspergillosis Revealing Asthma
Frontiers in Immunology, 2021 Allergic bronchopulmonary aspergillosis (ABPA) is an immunological pulmonary disorder caused by hypersensitivity to Aspergillus which colonizes the airways of patients with asthma and cystic fibrosis. Its diagnosis could be difficult in some cases due to
Houda Snen +17 more
doaj +1 more source
On optimal designs for clinical trials: An updated review [PDF]
, 2019 Optimization of clinical trial designs can help investigators achieve higher qualityresults for the given resource constraints. The present paper gives an overviewof optimal designs for various important problems that arise in different stages ofclinical
Ryeznik, Yevgen +2 more
core +2 more sources
Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications
Pharmaceuticals, 2010 In the past twenty years, 14 new antiepileptic drugs have been approved for use in the United States and/or Europe. These drugs are eslicarbazepine acetate, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, pregabalin ...
Matthew D. Krasowski
doaj +1 more source
Gold amides as anticancer drugs: synthesis and activity studies [PDF]
, 2013 Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery.
Amagai +34 more
core +1 more source
Nitrofurantoin-induced interstitial lung disease
Journal of Clinical and Scientific Research, 2022 We report the case of a 55-year-old woman diagnosed with interstitial lung disease due to long-term nitrofurantoin therapy that was administered for recurrent urinary tract infection.
Mohammed Salman +3 more
doaj +1 more source
Apoptotic and chemotherapeutic properties of iron(III)-salophene in an ovarian cancer animal model [PDF]
, 2008 The cytotoxicity of organometallic compounds iron(III)-, cobalt(III)-, manganese(II)-, and copper(II)-salophene (-SP) on platinum-resistant ovarian cancer cell lines was compared. Fe-SP displayed selective cytotoxicity (IC 50 at ∼1 μM) against SKOV-3 and
Alptürk, O +8 more
core +3 more sources
Evaluation of the efficacy and toxicity of protocol cisplatin, 5-fluorouracil, leucovorin compared to protocol fluorouracil, doxorubicin and mitomycin C in locally advanced and metastatic gastric cancer [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2012 Introduction. Still there is no consensus on the choice of the most efficient and the least toxic chemotherapy regimen in the treatment of advanced gastric cancer. Nowadays few therapy protocols are available for treating this disease.
Andrić Zoran +6 more
doaj +1 more source
Adverse reactions of amiodarone [PDF]
, 2019 Adverse drug reaction is defined by the World Health Organization as any response to a drug that is noxious and unintended and occurs at a dose normally used in man.
Calvosa, Leonardo +5 more
core +1 more source