Low-Dose Continuous 5-Fluorouracil Combined with Leucovorin, nab-Paclitaxel, Oxaliplatin, and Bevacizumab for Patients with Advanced Pancreatic Cancer: A Retrospective Analysis. [PDF]
, 2018 BackgroundContinuous-infusion 5-fluorouracil (5FU) and calcium leucovorin plus nab-paclitaxel and oxaliplatin have been shown to be active in patients with pancreatic cancer.
Bedford, Rudolph +7 more
core +1 more source
Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity
Frontiers in Cell and Developmental Biology, 2022 Nrf2 and NF-κB are important regulators of the response to oxidative stress and inflammation in the body. Previous pharmacological and genetic studies have confirmed crosstalk between the two.
Wen Gao +7 more
semanticscholar +1 more source
Sağlık Akademisi Kastamonu, 2016 Amaç: Araştırma; cerrahi kliniklerinde yatan yaşlı hastaların ilaç kullanımlarını etkileyebilecek bilgi ve uygulamalarının belirlenmesi amacıyla tanımlayıcı olarak yapılmıştır.
Esra Demirarslan
doaj +1 more source
Toxicity-related antiretroviral drug treatment modifications in individuals starting therapy: a cohort analysis of time patterns, sex, and other risk factors. [PDF]
, 2013 BackgroundModifications to combination antiretroviral drug therapy (CART) regimens can occur for a number of reasons, including adverse drug effects.
Begovac, Josip +4 more
core +1 more source
A Phase I Study of Abiraterone Acetate Combined with BEZ235, a Dual PI3K/mTOR Inhibitor, in Metastatic Castration Resistant Prostate Cancer. [PDF]
, 2017 Lessons learnedThe combination of standard dose abiraterone acetate and BEZ235, a pan-class I PI3K and mTORC1/2 inhibitor, was poorly tolerated in men with progressive mCRPC.Although the clinical development of BEZ235 has been discontinued in prostate ...
Friedlander, Terence +6 more
core +1 more source
Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling.
ACS Chemical Biology, 2019 It is increasingly clear that interindividual variability in human gut microbial composition contributes to differential drug responses. For example, gastrointestinal (GI) toxicity is not observed in all patients treated with the anticancer drug ...
Parth B Jariwala +12 more
semanticscholar +1 more source
Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells [PDF]
, 2019 Controlled delivery of multiple chemotherapeutics can improve the effectiveness of treatments and reduce side effects and relapses. Here in, we used albumin-stabilized gold nanoclusters modified with doxorubicin and SN38 (AuNCs-DS) as combined therapy ...
Aguado, Tania +11 more
core +2 more sources
Online Analysis of Drug Toxicity to Cells with Shear Stress on an Integrated Microfluidic Chip.
ACS Sensors, 2019 Mechanical stimulation, especially fluid shear stress (FSS), is essential for a cell to regulate regular behaviors. A high-throughput platform to provide varying FSS for cell research is desperately required for better mimicking of the complex fluidic ...
Shuo Feng +4 more
semanticscholar +1 more source
Drug Metabolism And Disposition, 2022 The market for large molecule biologic drugs has grown rapidly, including antisense oligonucleotide (ASO) drugs. ASO drugs work as single-stranded synthetic oligonucleotides that reduce production or alter functions of disease-causing proteins through ...
Feryal Alhamadani +7 more
semanticscholar +1 more source
Open Life Sciences, 2021 MTHFR is a crucial enzyme in folate metabolism. This study aimed to determine the relationship between MTHFR genetic polymorphism and elimination and toxicities of methotrexate (MTX).
Shen Yaqing +3 more
doaj +1 more source