Results 41 to 50 of about 5,373,155 (364)

A simple model to solve a complex drug toxicity problem.

Toxicological Research, 2019
Linear drug toxicity models like therapeutic index (TI), physicochemical rules (rule of five, 3/75), ligand efficiency indices (LEI), ideal pharmacokinetic (PK) and pharmacodynamic (PD) profiles are widely used in drug discovery and development. In spite
Vaibhav A. Dixit
semanticscholar   +1 more source

Nitrofurantoin-induced interstitial lung disease

Journal of Clinical and Scientific Research, 2022
We report the case of a 55-year-old woman diagnosed with interstitial lung disease due to long-term nitrofurantoin therapy that was administered for recurrent urinary tract infection.
Mohammed Salman, Adarsh Marikanty, Shiva Kumar Reddy, Mallikarjuna Shetty   +3 more
doaj   +1 more source

Clinical commissioning of an adaptive radiotherapy platform: Results and recommendations

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Online adaptive radiotherapy platforms present a unique challenge for commissioning as guidance is lacking and specialized adaptive equipment, such as deformable phantoms, are rare. We designed a novel adaptive commissioning process consisting of end‐to‐end tests using standard clinical resources.
Kelly Kisling, Timothy D. Keiper, Daniela Branco, Grace Gwe‐Ya Kim, Kevin L Moore, Xenia Ray   +5 more
wiley   +1 more source

Papulopustular lesions of the face caused by panitumumab: case report and literature review

Journal of Oral Medicine and Oral Surgery, 2018
Introduction: Panitumumab (VECTIBIX®) is a monoclonal antibody used alone or in combination with a chemotherapy for management of metastatic colorectal cancer.
Ravasco Jonathan, Lebaud Philippe, Bodin Hélène   +2 more
doaj   +1 more source

Bioprinted 3D vascularized tissue model for drug toxicity analysis.

Biomicrofluidics, 2017
To develop biomimetic three-dimensional (3D) tissue constructs for drug screening and biological studies, engineered blood vessels should be integrated into the constructs to mimic the drug administration process in vivo.
Solange Massa, Mahmoud A. S. Sakr, Jungmok Seo, Praveen Bandaru, Andrea Arneri, S. Bersini, E. Zare-Eelanjegh, E. Jalilian, Byung‐Hyun Cha, Silvia Antona, Alessandro Enrico, Yuan Gao, Shabir Hassan, J. Acevedo, M. Dokmeci, Y. S. Zhang, A. Khademhosseini, S. Shin   +17 more
semanticscholar   +1 more source

Volume staging for arteriovenous malformation SRS treatment using VMAT

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Volume staging involves dividing the target volume into smaller parts and treating each part separately. In this study, the feasibility of volume‐staged stereotactic radiosurgery (VS‐SRS) on a linear accelerator using volumetric modulated arc therapy (VMAT) and a frameless patient positioning system is investigated.
Claudia Mendez, Ermias Gete
wiley   +1 more source

Acute recreational drug toxicity

Medicine, 2018
The aim of the study was to compare self-reported and analytically confirmed substance use in cases of acute recreational drug toxicity. We performed a retrospective analysis of emergency department presentations of acute recreational drug toxicity over ...
E. Liakoni, C. Yates, A. Dines, P. Dargan, F. Heyerdahl, K. Hovda, D. Wood, F. Eyer, M. Liechti   +8 more
semanticscholar   +1 more source

Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients

Frontiers in Pharmacology, 2019
Nudix Hydrolase 15 (NUDT15) and Thiopurine S-Methyltransferase (TPMT) are strong genetic determinants of thiopurine toxicity in pediatric acute lymphoblastic leukemia (ALL) patients.
Yoomi Park, Hyery Kim, Jung Yoon Choi, Jung Yoon Choi, Sunmin Yun, Byung-Joo Min, Myung-Eui Seo, Ho Joon Im, Hyoung Jin Kang, Hyoung Jin Kang, Ju Han Kim, Ju Han Kim   +11 more
doaj   +1 more source

Alanine Aminotransferase and Bilirubin Dynamic Evolution Pattern as a Novel Model for the Prediction of Acute Liver Failure in Drug-Induced Liver Injury

Frontiers in Pharmacology, 2022
Aims: To develop, optimize, and validate a novel model using alanine aminotransferase (ALT) and total bilirubin (TB) dynamic evolution patterns in predicting acute liver failure (ALF) in drug-induced liver injury (DILI) patients.Methods: The demographics,
Ruiyuan Yang, Kexin Li, Cailun Zou, Aileen Wee, Jimin Liu, Liwei Liu, Min Li, Ting Wu, Yu Wang, Zikun Ma, Yan Wang, Jingyi Liu, Ang Huang, Ying Sun, Binxia Chang, Qingsheng Liang, Jidong Jia, Zhengsheng Zou, Xinyan Zhao   +18 more
doaj   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source