Results 51 to 60 of about 5,373,155 (364)
Ethambutol toxic optic neuropathy: A case report and review
African Vision and Eye Health, 2018 This article presents a case of ethambutol toxic optic neuropathy determined during the routine optometric examination of a 66-year-old man. Ethambutol is an established drug for the treatment of tuberculosis, but has significant side effects, notably ...
Kevin C. Phillips, Peter C. Clarke-Farr
doaj +1 more source
Adverse effects of long term, continual administration of high doses of albendazole in the treatment of echinococcal disease [PDF]
Vojnosanitetski Pregled, 2008 Background/Aim. Modern treatment of cystic echinococcosis, except for surgical treatment and percutaneous drainage of cyst considers also administration of albendazole as a type of individual therapy.
Jevtić Miodrag +6 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Scientific ReportsDurian (Durio zibethinus L.) fruit pulp is a rich source of γ-glutamylcysteine (γ-EC), a direct precursor to the antioxidant glutathione (GSH). This study elucidated the in vitro neuroprotective potential of unripe durian fruit pulp extract (UDE) against
Gholamreza Khaksar +5 more
doaj +1 more source
An Update on the Relationship of SARS-CoV-2 and Male Reproduction
Frontiers in Endocrinology, 2021 Since the outbreak of the COVID-19, up to now, infection cases have been continuously rising to over 200 million around the world. Male bias in morbidity and mortality has emerged in the COVID-19 pandemic. The infection of SARS-CoV-2 has been reported to
Juncen Guo +9 more
doaj +1 more source
Graph2MDA: a multi-modal variational graph embedding model for predicting microbe-drug associations [PDF]
arXiv, 2021 Accumulated clinical studies show that microbes living in humans interact closely with human hosts, and get involved in modulating drug efficacy and drug toxicity. Microbes have become novel targets for the development of antibacterial agents. Therefore, screening of microbe-drug associations can benefit greatly drug research and development.
arxiv
Bayesian dose-regimen assessment in early phase oncology incorporating pharmacokinetics and pharmacodynamics [PDF]
, 2020 Phase I dose-finding trials in oncology seek to find the maximum tolerated dose (MTD) of a drug under a specific schedule. Evaluating drug-schedules aims at improving treatment safety while maintaining efficacy. However, while we can reasonably assume that toxicity increases with the dose for cytotoxic drugs, the relationship between toxicity and ...
arxiv +1 more source
Journal of Toxicologic Pathology, 2017 Nonclinical juvenile animal tests perform a valuable role in determining adverse drug effects during periods of organogenesis and/or functional maturation.
J. Seely
semanticscholar +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, EarlyView.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source
Open Life Sciences, 2021 MTHFR is a crucial enzyme in folate metabolism. This study aimed to determine the relationship between MTHFR genetic polymorphism and elimination and toxicities of methotrexate (MTX).
Shen Yaqing +3 more
doaj +1 more source