Results 61 to 70 of about 6,137,811 (297)

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]

, 2020
Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher, Dorrestein, Pieter C, Jarmusch, Alan K, Knight, Rob, Liyanage, Marlon, Ma, Joseph D, Momper, Jeremiah D, Tsunoda, Shirley M, Vrbanac, Alison   +8 more
core   +1 more source

Durian fruit pulp extract enhances intracellular glutathione levels, mitigating oxidative stress and inflammation for neuroprotection

Scientific Reports
Durian (Durio zibethinus L.) fruit pulp is a rich source of γ-glutamylcysteine (γ-EC), a direct precursor to the antioxidant glutathione (GSH). This study elucidated the in vitro neuroprotective potential of unripe durian fruit pulp extract (UDE) against
Gholamreza Khaksar, Su Lwin Lwin Myint, Hasriadi, Pasarapa Towiwat, Supaart Sirikantaramas, Ratchanee Rodsiri   +5 more
doaj   +1 more source

Atypical Pharmacodynamic Properties and Metabolic Profile of the Abused Synthetic Cannabinoid AB-PINACA: Potential Contribution to Pronounced Adverse Effects Relative to Δ9-THC

Frontiers in Pharmacology, 2018
Recreational use of marijuana is associated with few adverse effects, but abuse of synthetic cannabinoids (SCBs) can result in anxiety, psychosis, chest pain, seizures and death.
Rachel D. Hutchison, Benjamin M. Ford, Lirit N. Franks, Catheryn D. Wilson, Azure L. Yarbrough, Ryoichi Fujiwara, Mark K. Su, Denise Fernandez, Laura P. James, Jeffery H. Moran, Amy L. Patton, William E. Fantegrossi, Anna Radominska-Pandya, Paul L. Prather   +13 more
doaj   +1 more source

NLRP3 Inflammasome: A Promising Therapeutic Target for Drug-Induced Toxicity

Frontiers in Cell and Developmental Biology, 2021
Drug-induced toxicity, which impairs human organ function, is a serious problem during drug development that hinders the clinical use of many marketed drugs, and the underlying mechanisms are complicated.
Shan-shan Wei, Wanjun Ma, Bi-kui Zhang, Wenqun Li   +3 more
semanticscholar   +1 more source

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis [PDF]

, 2011
Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is ...
AA Poltera, Amy Jones, B Evrard, B Raz, Barbara Bradley, BJ Berger, C Burri, C Burri, CA Hunter, Christopher McCabe, E Torreele, EW Hurst, FIC Apted, FW Jennings, George Gettinby, H Hirumi, J Opigo, J Pepin, J Pepin, J Rodgers, J Rodgers, Jayne Raper, Jean Rodgers, JH Zar, JLM Atouguia, JW Wong, Michael P. Barrett, MP Barrett, MP Barrett, NJ Abbott, Peter G. E. Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, RL Carrier, S Ben Zirar, S Gibaud, SL Soignet, Stéphane Gibaud, T Loftsson, T Loftsson, V Lejon, VJ Stella   +45 more
core   +7 more sources

A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy

Journal of Toxicologic Pathology, 2017
Nonclinical juvenile animal tests perform a valuable role in determining adverse drug effects during periods of organogenesis and/or functional maturation.
J. Seely
semanticscholar   +1 more source

New Generation Nanomedicines Constructed from Self-Assembling Small-Molecule Prodrugs Alleviate Cancer Drug Toxicity.

Cancer Research, 2017
The therapeutic index for chemotherapeutic drugs is determined in part by systemic toxicity, so strategies for dose intensification to improve efficacy must also address tolerability.
Hangxiang Wang, Zhongjie Lu, Lijiang Wang, Tingting Guo, Jiaping Wu, Jianqin Wan, Liqian Zhou, Hui Li, Zhen Li, Donghai Jiang, P. Song, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng   +14 more
semanticscholar   +1 more source

Comparative in silico and in vivo study of the antioxidant activity of lactoferrin, Geobacillus stearothermophilus, and Lactobacillus delbrueckii subsp. lactis against Rotavirus infection in male mice

BMC Microbiology
Rotavirus is a major cause of pediatric gastroenteritis, for which effective treatments are limited. This study investigates the antioxidant and antiviral potential of lactoferrin, Geobacillus stearothermophilus, and Lactobacillus delbrueckii subsp ...
Tarek A. M. Ismail, Naglaa Elshafey, Shehab E. Talat, Mona E. Saif, Amany Mohammed Hegab, Komla Mawunyo Dossouvi, Hanan M. Alharbi, Amr Elkelish, Khalid Abd El Ghany   +8 more
doaj   +1 more source

Case Report: Effective methotrexate removal by combined hemodialysis and polymeric resin hemoadsorption

Frontiers in Nephrology
BackgroundHigh-dose methotrexate (HDMTX) is central to treating primary central nervous system lymphoma but carries a risk of acute kidney injury (AKI), which can delay methotrexate (MTX) clearance and increase toxicity.
Maria Rita Dias, Carla Nicolau, Hugo Ferreira, Sérgio Chacim, Isabel Oliveira, Gonçalo de Câmara Negalha, José Mário Mariz, José Maximino Costa   +7 more
doaj   +1 more source

Clinicians’ attitudes and knowledge of medicinal cannabis in opioid dependence treatment clinics in New South Wales, Australia

Journal of Cannabis Research
Background There are no prior studies investigating the attitudes and knowledge of opioid treatment program (OTP) clinicians on prescribed medicinal cannabis in OTP clients. This study examined the OTP clinicians' medicinal cannabis experience, knowledge,
Laila Parvaresh, Llewellyn Mills, Jaleh Gholami, Louisa Jansen, Nazila Jamshidi, Kate Baker, Christopher Tremonti, Marguerite Tracy, Adrian Dunlop, Nicholas Lintzeris   +9 more
doaj   +1 more source