Results 61 to 70 of about 5,373,155 (364)

Anti-Epileptic Drug Toxicity in Children

Children, 2018
Anti-epileptic drugs (AEDs) have had a major impact on children, improving their quality of life and significantly reducing both morbidity and mortality. They are, however, associated with significant toxicity. Behavioural problems and somnolence are the
I. Choonara
semanticscholar   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Toxicidade hepática é rara em pacientes com artrite reumatoide usando terapia combinada de leflunomida e metotrexato Liver toxicity is rare in rheumatoid arthritis patients using combination therapy with leflunomide and methotrexate

Revista Brasileira de Reumatologia, 2011
OBJETIVO: De acordo com alguns estudos, a associação de leflunomida (LEF) a pacientes portadores de artrite reumatoide não responsivos a metotrexato (MTX) aumentou a eficácia do tratamento, elevando, porém, o risco de toxicidade hepática.
Jorge Augusto Nunes Rodrigues Alves, Sonia Cristina de Magalhães Souza Fialho, Edelton Flávio Morato, Gláucio RicardoWerner de Castro, Adriana Fontes Zimmermann, Giovana Gomes Ribeiro, Fabrício Souza Neves, Ivânio Alves Pereira   +7 more
doaj   +1 more source

Case Report: Allergic Bronchopulmonary Aspergillosis Revealing Asthma

Frontiers in Immunology, 2021
Allergic bronchopulmonary aspergillosis (ABPA) is an immunological pulmonary disorder caused by hypersensitivity to Aspergillus which colonizes the airways of patients with asthma and cystic fibrosis. Its diagnosis could be difficult in some cases due to
Houda Snen, Houda Snen, Aicha Kallel, Aicha Kallel, Hana Blibech, Hana Blibech, Sana Jemel, Sana Jemel, Nozha Ben Salah, Nozha Ben Salah, Sonia Marouen, Nadia Mehiri, Nadia Mehiri, Slah Belhaj, Bechir Louzir, Bechir Louzir, Kalthoum Kallel, Kalthoum Kallel   +17 more
doaj   +1 more source

DROID: Dose-ranging Approach to Optimizing Dose in Oncology Drug Development [PDF]

arXiv, 2022
In the era of targeted therapy, there has been increasing concern about the development of oncology drugs based on the "more is better" paradigm, developed decades ago for chemotherapy. Recently, the US Food and Drug Administration (FDA) initiated Project Optimus to reform the dose optimization and dose selection paradigm in oncology drug development ...
arxiv  

Cancer phase I trial design using drug combinations when a fraction of dose limiting toxicities is attributable to one or more agents [PDF]

Biometrical Journal (2018), 2017
Drug combination trials are increasingly common nowadays in clinical research. However, very few methods have been developed to consider toxicity attributions in the dose escalation process. We are motivated by a trial in which the clinician is able to identify certain toxicities that can be attributed to one of the agents.
arxiv   +1 more source

New Generation Nanomedicines Constructed from Self-Assembling Small-Molecule Prodrugs Alleviate Cancer Drug Toxicity.

Cancer Research, 2017
The therapeutic index for chemotherapeutic drugs is determined in part by systemic toxicity, so strategies for dose intensification to improve efficacy must also address tolerability.
Hangxiang Wang, Zhongjie Lu, Lijiang Wang, Tingting Guo, Jiaping Wu, Jianqin Wan, Liqian Zhou, Hui Li, Zhen Li, Donghai Jiang, P. Song, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng   +14 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Acute Pancreatitis Secondary to Ciprofloxacin Therapy in Patients with Infectious Colitis

Gut and Liver, 2014
Background/AimsCiprofloxacin is considered to be a safe and effective treatment for acute infectious colitis. However, this drug may cause drug-induced pancreatitis, albeit rarely.Methods : From March 2007 to February 2012, we studied 227 patients who ...
doaj   +1 more source

Network and Pathway Analysis of Toxicogenomics Data

Frontiers in Genetics, 2018
Toxicogenomics is the study of the molecular effects of chemical, biological and physical agents in biological systems, with the aim of elucidating toxicological mechanisms, building predictive models and improving diagnostics.
Gal Barel, Ralf Herwig
doaj   +1 more source