Results 71 to 80 of about 6,137,811 (297)

Beneficial effects of α-lipoic acid in diabetes- and drug- induced liver injury [PDF]

Archives of Biological Sciences, 2018
This review summarizes the effects of α-lipoic acid (LA) on liver damage and complications in diabetes and drug toxicity. LA is a naturally occurring dithiol compound that plays an essential role in mitochondrial metabolism in its protein-bound form.
Uskoković Aleksandra, Dinić Svetlana, Grdović Nevena, Arambašić-Jovanović Jelena, Vidaković Melita, Poznanović Goran, Mihailović Mirjana   +6 more
doaj   +1 more source

A Rare Cause of Drug-Induced Pancytopenia: Trimethoprim–Sulfamethoxazole-Induced Pancytopenia

Clinics and Practice, 2021
Pancytopenia is a decrease across cellular hematological lines. Many different etiologies can cause this clinical picture including viral and bacterial infections, chemicals, malignancy, and medications.
Khalid Sawalha, Philip T. Sobash, Gilbert-Roy Kamoga   +2 more
doaj   +1 more source

Toxicogenomic module associations with pathogenesis: a network-based approach to understanding drug toxicity

The Pharmacogenomics Journal, 2017
Despite investment in toxicogenomics, nonclinical safety studies are still used to predict clinical liabilities for new drug candidates. Network-based approaches for genomic analysis help overcome challenges with whole-genome transcriptional profiling ...
Jeffrey J. Sutherland, Yue Webster, Jeffrey A. Willy, George H. Searfoss, Keith M. Goldstein, A. R. Irizarry, D. G. Hall, James L. Stevens   +7 more
semanticscholar   +1 more source

Ziziphus spina-christi alleviates paracetamol-induced hepatorenal toxicity in rats through in vivo and computational approaches

Scientific Reports
Paracetamol (PCM) overdose is a leading cause of drug-induced liver and kidney injury, necessitating effective therapeutic strategies. This study aimed to evaluate the protective effects of Ziziphus spina-christi (ZSC), a traditional medicinal plant with
Ehsan Kh. M. Khedre, Amany M. M. Hegab, Amira A. El-Mahis, Amina A. S. Abdel Rahman, Sherien H. B. Elwakeel, Ali S. Abdelhameed, Vittorio Calabrese, Ursula M. Jacob, Eman S. G. Hassan   +8 more
doaj   +1 more source

Drug-Loaded, Bivalent-Bottle-Brush Polymers by Graft-through ROMP [PDF]

, 2010
Graft through ring-opening metathesis polymerization (ROMP) using ruthenium N heterocyclic carbene catalysts has enabled the synthesis of bottle-brush polymers with unprecedented ease and control Here we report the first bivalent-brush polymers, these ...
Burts, Alan O., Durrell, Alec C., Grubbs, Robert H., Johnson, Jeremiah A., Lu, Ying Y., Tirrell, David A., Xia, Yan   +6 more
core   +1 more source

Caenorhabditis elegans as a model system for studying drug induced mitochondrial toxicity [PDF]

, 2015
Today HIV-1 infection is recognized as a chronic disease with obligatory lifelong treatment to keep viral titers below detectable levels. The continuous intake of antiretroviral drugs however, leads to severe and even life-threatening side effects ...
Brul, Stanley, de Boer, Richard, De Vos, Winnok, Manders, Erik MM, Smith, Ruben L, van der Spek, Hans   +5 more
core   +5 more sources

Drug-Induced Liver Toxicity

Acta Medica Bulgarica
The liver performs many vital functions such as regulating homeostasis, bile production, storage of vitamins, and more. Another important function of the liver is to neutralize toxic substances entering the body. Substances entering the human body can be
Stavrakeva K., Popova M., Esad M., Apostolova E., Kokova V., Bacelova M., Alakidi A., Bivolarska A.   +7 more
doaj   +1 more source

Incidence, risk factors and ophthalmic clinical characteristic of ethambutol-induced optic neuropathy: 7-year experience

Frontiers in Ophthalmology, 2023
BackgroundThe purpose of this research was to investigate the characteristics, clinical manifestations, incidence, and risk factors in ethambutol-induced optic neuropathy (EON) in the Thai population.MethodsPatients treated with ethambutol for ...
Pareena Chaitanuwong, Pareena Chaitanuwong, Supaporn Srithawatpong, Supaporn Srithawatpong, Paisan Ruamviboonsuk, Paisan Ruamviboonsuk, Supanut Apinyawasisuk, Supanut Apinyawasisuk, Akechanok Watcharapanjamart, Akechanok Watcharapanjamart, Heather E. Moss, Heather E. Moss   +11 more
doaj   +1 more source

Acute recreational drug toxicity

Medicine, 2018
The aim of the study was to compare self-reported and analytically confirmed substance use in cases of acute recreational drug toxicity. We performed a retrospective analysis of emergency department presentations of acute recreational drug toxicity over ...
E. Liakoni, C. Yates, A. Dines, P. Dargan, F. Heyerdahl, K. Hovda, D. Wood, F. Eyer, M. Liechti   +8 more
semanticscholar   +1 more source

Evaluation of Potential Drug-Drug Interactions and Association with Adverse Drug Reactions in Predialysis Chronic Kidney Disease Patients at Indonesian National Referral Hospital

Acta Medica Indonesiana, 2023
Background: Chronic kidney disease (CKD) is often accompanied by a variety of comorbidities that require several medications thus, polypharmacy is unavoidable. One of the consequences of polypharmacy is the occurrence of potential drug-drug interactions (
Triasti Khusfiani, Vivian Soetikno, Ni Made Hustrini, Nafrialdi Nafrialdi   +3 more
doaj