Results 71 to 80 of about 5,373,155 (364)

Psychosis associated with acute recreational drug toxicity: a European case series

BMC Psychiatry, 2016
BackgroundPsychosis can be associated with acute recreational drug and novel psychoactive substance (NPS) toxicity. However, there is limited data available on how common this is and which drugs are most frequently implicated. We describe a European case
O. M. Vallersnes, A. Dines, D. Wood, C. Yates, F. Heyerdahl, K. Hovda, I. Giraudon, P. Dargan   +7 more
semanticscholar   +1 more source

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

FEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet, Magali Leroy, Alexandre Maes, Ciarán Condon, Frédérique Braun   +4 more
wiley   +1 more source

Comparative in silico and in vivo study of the antioxidant activity of lactoferrin, Geobacillus stearothermophilus, and Lactobacillus delbrueckii subsp. lactis against Rotavirus infection in male mice

BMC Microbiology
Rotavirus is a major cause of pediatric gastroenteritis, for which effective treatments are limited. This study investigates the antioxidant and antiviral potential of lactoferrin, Geobacillus stearothermophilus, and Lactobacillus delbrueckii subsp ...
Tarek A. M. Ismail, Naglaa Elshafey, Shehab E. Talat, Mona E. Saif, Amany Mohammed Hegab, Komla Mawunyo Dossouvi, Hanan M. Alharbi, Amr Elkelish, Khalid Abd El Ghany   +8 more
doaj   +1 more source

Analytical confirmation of synthetic cannabinoids in a cohort of 179 presentations with acute recreational drug toxicity to an Emergency Department in London, UK in the first half of 2015

Clinical toxicology, 2017
Context: Synthetic cannabinoid receptor agonists are the largest group of new psychoactive substances reported in the last decade; in this study we investigated how commonly these drugs are found in patients presenting to the Emergency Department with ...
Rachelle Abouchedid, S. Hudson, Natalie Thurtle, Takahiro Yamamoto, James H. Ho, G. Bailey, M. Wood, Nele Sadones, C. Stove, A. Dines, J. Archer, D. Wood, P. Dargan   +12 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Drug-Induced Liver Toxicity

Acta Medica Bulgarica
The liver performs many vital functions such as regulating homeostasis, bile production, storage of vitamins, and more. Another important function of the liver is to neutralize toxic substances entering the body. Substances entering the human body can be
Stavrakeva K., Popova M., Esad M., Apostolova E., Kokova V., Bacelova M., Alakidi A., Bivolarska A.   +7 more
doaj   +1 more source

Deep Learning Prediction of Adverse Drug Reactions Using Open TG-GATEs and FAERS Databases [PDF]

, 2020
With the advancements in Artificial intelligence (AI) and the accumulation of healthrelated big data, it has become increasingly feasible and commonplace to leverage machine learning technologies to analyze clinical and omics metadata to assess the possibility of adverse drug reactions or events (ADRs) in the course of drug discovery.
arxiv   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

PARP inhibitors combined with radiotherapy: are we ready?

Frontiers in Pharmacology, 2023
PARP was an enzyme found in the nucleus of eukaryotic cells that played a crucial role in repairing damaged DNA. Recently, PARP inhibitors have demonstrated great potential in cancer treatment.
Chen Sun, Alan Chu, Rui Song, Shijia Liu, Ting Chai, Xin Wang, Zongwen Liu   +6 more
doaj   +1 more source

Toxicogenomic module associations with pathogenesis: a network-based approach to understanding drug toxicity

The Pharmacogenomics Journal, 2017
Despite investment in toxicogenomics, nonclinical safety studies are still used to predict clinical liabilities for new drug candidates. Network-based approaches for genomic analysis help overcome challenges with whole-genome transcriptional profiling ...
JJ Sutherland, JA Willy, GH Searfoss, KM Goldstein, AR Irizarry, JL Stevens   +5 more
semanticscholar   +1 more source