Results 81 to 90 of about 5,373,155 (364)

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Metabolomics highlights biochemical perturbations occurring in the kidney and liver of mice administered a human dose of colistin

Frontiers in Molecular Biosciences
Introduction: Colistin (CMS) is used for the curation of infections caused by multidrug-resistant bacteria. CMS is constrained by toxicity, particularly in kidney and neuronal cells.
I. Barla, I. V. Dagla, A. Daskalopoulou, M. Panagiotopoulou, M. Kritikaki, P. Dalezis, N. Thomaidis, A. Tsarbopoulos, D. Trafalis, E. Gikas   +9 more
doaj   +1 more source

Doxorubicin-Based Hybrid Compounds as Potential Anticancer Agents: A Review

Molecules, 2022
The scarcity of novel and effective therapeutics for the treatment of cancer is a pressing and alarming issue that needs to be prioritized. The number of cancer cases and deaths are increasing at a rapid rate worldwide.
Sijongesonke Peter, Sibusiso Alven, Rejoice Bethusile Maseko, Blessing Atim Aderibigbe   +3 more
doaj   +1 more source

Discovering Synergistic Drug Combinations for COVID with Biological Bottleneck Models [PDF]

arXiv, 2020
Drug combinations play an important role in therapeutics due to its better efficacy and reduced toxicity. Recent approaches have applied machine learning to identify synergistic combinations for cancer, but they are not applicable to new diseases with limited combination data. Given that drug synergy is closely tied to biological targets, we propose a \
arxiv  

Underestimated impact of novel psychoactive substances: laboratory confirmation of recreational drug toxicity in Oslo, Norway

Clinical toxicology, 2017
Context: Recreational drug toxicity is frequent. Availability of new psychoactive substances is steadily increasing. However, data with verified analyses from clinical settings are limited. To evaluate the impact of novel psychoactive substances (NPS) on
O. M. Vallersnes, Per Sverre Persett, E. Øiestad, R. Karinen, F. Heyerdahl, K. Hovda   +5 more
semanticscholar   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Advanced Liver-on-a-Chip Model for Evaluating Drug Metabolism and Hepatotoxicity

Biosensors
The liver has many important functions, including the biotransformation of drugs and detoxification of the human organism. As such, it is also exposed to many harmful substances, which leads to disorders and diseases such as cirrhosis. For these reasons,
Sonia Frojdenfal, Agnieszka Zuchowska
doaj   +1 more source

ZeGlobalTox: An Innovative Approach to Address Organ Drug Toxicity Using Zebrafish

International Journal of Molecular Sciences, 2017
Toxicity is one of the major attrition causes during the drug development process. In that line, cardio-, neuro-, and hepatotoxicities are among the main reasons behind the retirement of drugs in clinical phases and post market withdrawal.
Carles Cornet, Simone Calzolari, R. Miñana-Prieto, Sylvia Dyballa, Els J P van Doornmalen, Helma Rutjes, T. Savy, Davide D’Amico, J. Terriente   +8 more
semanticscholar   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Evaluation of the efficacy and toxicity of protocol cisplatin, 5-fluorouracil, leucovorin compared to protocol fluorouracil, doxorubicin and mitomycin C in locally advanced and metastatic gastric cancer [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2012
Introduction. Still there is no consensus on the choice of the most efficient and the least toxic chemotherapy regimen in the treatment of advanced gastric cancer. Nowadays few therapy protocols are available for treating this disease.
Andrić Zoran, Ranđelović Tomislav, Kovčin Vladimir, Gutović Jasmina, Crevar Slobodanka, Murtezani Zafir, Kostić Sanja   +6 more
doaj   +1 more source