Results 81 to 90 of about 6,137,811 (297)

In silico assessment of chronic toxicity of a combination drug namely ‘Olmesartan medoxomil and Hydrochlorothiazide’, marketed in Bangladesh [PDF]

, 2021
Matrika Saha Roy, Rehnuma Tanjin, Tanmoy Debnath, Bidduth Kumar Sarkar, Prema Modak, Milon Mondal, Arghya Prosun Sarkar, Md Ariful Islam, Sukalyan Kumar Kundu   +8 more
openalex   +1 more source

ZeGlobalTox: An Innovative Approach to Address Organ Drug Toxicity Using Zebrafish

International Journal of Molecular Sciences, 2017
Toxicity is one of the major attrition causes during the drug development process. In that line, cardio-, neuro-, and hepatotoxicities are among the main reasons behind the retirement of drugs in clinical phases and post market withdrawal.
Carles Cornet, Simone Calzolari, R. Miñana-Prieto, Sylvia Dyballa, Els J P van Doornmalen, Helma Rutjes, T. Savy, Davide D’Amico, J. Terriente   +8 more
semanticscholar   +1 more source

BICEPP: an example-based statistical text mining method for predicting the binary characteristics of drugs

BMC Bioinformatics, 2011
Background The identification of drug characteristics is a clinically important task, but it requires much expert knowledge and consumes substantial resources.
Tsafnat Guy, Polasek Thomas M, Anthony Stephen, Lin Frank PY, Doogue Matthew P   +4 more
doaj   +1 more source

Selective serotonin-reuptake inhibitor and norepinephrine dopamine reuptake inhibitor antidepressants do not affect natural killer cell activity in vitro Antidepressivos inibidores seletivos de recaptação da serotonina e inibidores da recaptação de noradrenalina e dopamina não afetam a atividade celular natural killer in vitro

Jornal Brasileiro de Psiquiatria, 2009
OBJECTIVE: This study aims to evaluate the citotoxic activity of two commonly used anti-depressants: paroxetine and bupropion. We also evaluated the in vitro natural killer activity (NKA) after incubating the blood samples with the antidepressants ...
Gabriel J. Chittó Gauer, Vivian M. Rumjanek, Sebastião Francisco Costa, Ramiro Ronchetti, Rachel Rubin da Silva, Leonardo M. da Silva   +5 more
doaj   +1 more source

Evaluation of Drug Delivery and Efficacy of Ciprofloxacin-Loaded Povidone Foils and Nanofiber Mats in a Wound-Infection Model Based on Ex Vivo Human Skin [PDF]

, 2019
Topical treatment of wound infections is often a challenge due to limited drug availability at the site of infection. Topical drug delivery is an attractive option for reducing systemic side effects, provided that a more selective and sustained local ...
Bayer, Ilker S., Blume-Peytavi, Ulrike, Contardi, Marco, Jurisch, Jana, Rancan, Fiorenza, Schaudinn, Christoph, Vogt, Annika   +6 more
core   +2 more sources

Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial. [PDF]

, 2020
BACKGROUND: Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulcerans infection that damages the skin and subcutis. It is most prevalent in western and central Africa and Australia.
Abass, KM, Agossadou, D, Ampadu, EO, Asiedu, KB, Chauty, A, Egondi, TW, Frimpong, M, Ganlonon, L, Gateau, T, Grosset, J, Lehman, L, Macdonald, JM, Marion, E, Ochieng Otieno, M, Ohene, S-A, Omollo, R, Paintsil, A, Phillips, RO, Robert, J, Saizonou, R, Sarfo, FS, Sarpong, G, Sarpong, NF, Saunderson, P, Stienstra, Y, study team, Thompson, W, Tiendrebeogo, A, Treadwell, T, van der Werf, TS, Wansbrough-Jones, M, Wilson, T   +31 more
core   +3 more sources

Drug-induced blood toxicity.

Folia Pharmacologica Japonica, 2008
薬物誘発性の代表的な血液毒性として，赤血球減少（貧血），白血球減少，血小板減少がある．その主な機序として，造血器における造血系細胞の分化増殖過程への障害と末梢における成熟細胞の破壊が考えられている．医薬品の研究開発では，実験動物を用いた一般毒性試験の中で，末梢血を用いた血液学的検査により血液毒性を日常的に評価している．加えて，フローサイトメトリーを用いた造血系細胞の解析は，薬剤誘発性の血液毒性の機序推定に有用と考えられる．また，薬物による造血系細胞の分化増殖能への影響を調べるため，コロニー形成試験や細胞内ATP含量を指標に求める実験（ATPアッセイ）が行なわれている．近年，臨床における血液毒性を予測するため，in vitroのコロニー形成試験とin ...
Yumiko, Iwase, Naohisa, Tsutsui
openaire   +3 more sources

Correction to: Self-nanoemulsifying drug delivery system (SNEDDS) of docetaxel and carvacrol synergizes the anticancer activity and enables safer toxicity profile: optimization, and in-vitro, ex-vivo and in-vivo pharmacokinetic evaluation [PDF]

, 2023
Mohd Aman Mohd Ateeq, Mayur Aalhate, Srushti Mahajan, Gogikar Shiva Kumar, Sibu Sen, Hoshiyar Singh, Ujala Gupta, Indrani Maji, Amol G. Dikundwar, Santosh Kumar Guru, Pankaj Kumar Singh   +10 more
openalex   +1 more source

Possible Causes of Increased Domestic Violence among Military Veterans: PTSD or Mefloquine Toxicity? [PDF]

, 2016
After more than a decade at war, our returning service members and their families are facing enormous amounts of difficulty when returning home. PTSD and TBI, the signature wounds of these wars, have been well covered in the media.
Gourley, Shawn J
core   +1 more source

Medication Risk and Polypharmacy in Minority Older Adults [PDF]

, 2020
Medication Risk and Polypharmacy in Minority Older Adults Rusha Patel, Depts. of Biology and Chemistry, with Dr. Youssef Roman, VCU School of Pharmacy, Dr. Elvin Price, VCU School of Pharmacy, and Dr.
Patel, Rusha
core   +1 more source