Results 211 to 220 of about 132,064 (306)

Subcellular nanoparticle trafficking investigated with label-free, live cell imaging. [PDF]

Nanoscale Horiz
Nelson EB, Covarrubias G, Nabar N, Gomerdinger VF, Scott A, Hammond PT, Straehla JP.   +6 more
europepmc   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Prostate‑specific membrane antigen: Molecular functions and emerging roles as a therapeutic target (Review). [PDF]

Mol Med Rep
Watanabe R, Sakaue T, Miura N, Kikugawa T, Saika T.   +4 more
europepmc   +1 more source

BEHIND CLOSED DOORS: A QUALITATIVE EXAMINATION OF CONTRABAND DISPOSAL PRACTICES BY AUTHORITIES IN THE FIGHT AGAINST DRUG TRAFFICKING

Rhem Rick N. Corpuz
openalex   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Therapeutic Strategies to Overcome Payload Resistance of Trastuzumab Deruxtecan in HER2-Positive Cancers. [PDF]

Cancer Sci
Murase Y, Nanjo S, Arai S, Kondo S, Koba H, Liu Y, Fukuda K, Sato S, Kinoshita J, Inaki N, Ueda T, Nomura S, Tambo Y, Shimizu T, Horie M, Maeda D, Wong RW, Hosomichi K, Kobayashi T, Watanabe S, Yamamura K, Ohkura N, Abo M, Yano S.   +23 more
europepmc   +1 more source

Thinking Further about EU-Russia Cooperation: Drug Trafficking and Related Issues in Central Asia. EU Diplomacy Paper 09/2011, December 2011 [PDF]

, 2011
Nathan Dufour
openalex  

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

Generation of proliferative hESC-derived grape-clustered hepatocyte organoids with multipolar architecture as regenerative counterpart via synergy of YAP and IGF2 pathways. [PDF]

Cell Death Dis
Wu H, Liu S, Chen S, Qin C, Yan W, Cao X, Zhou Y, Duan Y.   +7 more
europepmc   +1 more source

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source