Results 31 to 40 of about 579,008 (311)

Interactions of Tenofovir, Lamivudine, Abacavir and Didanosine in Primary Human Cells

Pharmaceutics, 2011
Certain triple nucleoside/tide reverse transcriptase inhibitor (NRTI) regimens containing tenofovir (TDF) have been associated with rapid early treatment failure. The mechanism is unknown, but may be at the level of drug transport.
Saye H. Khoo, Omar Janneh
doaj   +1 more source

Assessing Trans-Inhibition of OATP1B1 and OATP1B3 by Calcineurin and/or PPIase Inhibitors and Global Identification of OATP1B1/3-Associated Proteins

Pharmaceutics, 2023
Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are key determinants of drug–drug interactions (DDIs). Various drugs including the calcineurin inhibitor (CNI) cyclosporine A (CsA) exert preincubation-induced trans-inhibitory effects upon ...
John T. Powell, Ruhul Kayesh, Alexandra Ballesteros-Perez, Khondoker Alam, Pascaline Niyonshuti, Erik J. Soderblom, Kai Ding, Chao Xu, Wei Yue   +8 more
doaj   +1 more source

Quality-by-Design-Based Development of a Voxelotor Self-Nanoemulsifying Drug-Delivery System with Improved Biopharmaceutical Attributes.

, 2021
Low aqueous solubility and poor oral bioavailability are limiting factors in the oral delivery of voxelotor, an antisickling agent. To overcome these limitations, a voxelotor self-nanoemulsifying drug delivery system was developed.
Mbinze, Jérémie K, Giulio G. Muccioli, Terrasi, Romano, Préat, Véronique, Buya, Aristote, Beloqui Garcia, Ana, Aristote B. Buya, Muccioli, Giulio, Véronique Préat, Jérémie K. Mbinze, Ana Beloqui, Romano Terrasi, Memvanga, Patrick B, Patrick B. Memvanga   +13 more
core   +1 more source

A comparison of theacrine and methylliberine with caffeine as salivary markers for determining gastric emptying

International Journal of Pharmaceutics: X
Gastric emptying is a critical determinant of the pharmacokinetics of orally administered drugs. A key limitation in studies using caffeine as a marker for gastric emptying is the requirement for prior caffeine abstinence, which can complicate study ...
Toni Wildgrube, Stefan Senekowitsch, Robin Krüger, Fabian Winter, Michael Grimm, Werner Weitschies, Philipp Schick   +6 more
doaj   +1 more source

A perfused multi-well bioreactor platform to assess tumor organoid response to a chemotherapeutic gradient

Frontiers in Bioengineering and Biotechnology, 2023
There is an urgent need to develop new therapies for colorectal cancer that has metastasized to the liver and, more fundamentally, to develop improved preclinical platforms of colorectal cancer liver metastases (CRCLM) to screen therapies for efficacy ...
Elisa Marie Wasson, Wei He, Jesse Ahlquist, William Fredrick Hynes, Michael Gregory Triplett, Aubree Hinckley, Eveliina Karelehto, Eveliina Karelehto, Delaney Ruth Gray-Sherr, Caleb Fisher Friedman, Claire Robertson, Claire Robertson, Maxim Shusteff, Robert Warren, Robert Warren, Matthew A. Coleman, Monica Lizet Moya, Elizabeth K. Wheeler   +17 more
doaj   +1 more source

Renal drug transporters and their significance in drug–drug interactions

Acta Pharmaceutica Sinica B, 2016
The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal proximal tubules, play an important role in tubular secretion and reabsorption of drug molecules in the kidney.
Jia Yin, Joanne Wang
openaire   +3 more sources

Tri-partite complex for axonal transport drug delivery achieves pharmacological effect.

, 2010
BACKGROUND: Targeted delivery of pharmaceutical agents into selected populations of CNS (Central Nervous System) neurons is an extremely compelling goal.
Sokoloff Alan J, Miri D Rabinowitz, Munglani, Raj, Filler, Aaron G, Filler, A.G, Munglani, R, Chris Abell, Rabinowitz, Miri D, Terrence W Deacon, Andrew ML Lever, Deacon Terrence W, Munglani Raj, Mark Bacon, Sokoloff, Alan J, Franklyn A Howe, Deacon, T.W, Whiteside, Garth T, Bacon, Mark, Howe, F.A, Abell, Chris, Sokoloff, AJ, Griffiths, J.R, Filler Aaron G, Lever, Andrew ML, Howe, FA, Alan J Sokoloff, Martyn Frederickson, Bell B Anthony, Bell, B.A, Bacon, M, Frederickson Martyn, Garth T Whiteside, Griffiths, John R, Abell, C, Aaron G Filler, B Anthony Bell, Griffiths John R, Rabinowitz Miri D, Bacon Mark, Bell, B Anthony, Lever, A.M.L, Frederickson, Martyn, Filler, AG, Abell Chris, Sokoloff, A.J, Frederickson, M, John R Griffiths, Lever Andrew ML, Whiteside Garth T, Deacon, Terrence W, Bell, BA, Whiteside, GT, Griffiths, JR, Rabinowitz, MD, Deacon, TW, Lever, AM, Whiteside, G.T, Howe Franklyn A, Howe, Franklyn A, Raj Munglani, Rabinowitz, M.D   +60 more
core   +1 more source

Interaction of ALK Inhibitors with Polyspecific Organic Cation Transporters and the Impact of Substrate-Dependent Inhibition on the Prediction of Drug–Drug Interactions

Pharmaceutics, 2023
Small molecules targeting aberrant anaplastic lymphoma kinase (ALK) are active against ALK-positive non-small-cell lung cancers and neuroblastoma. Several targeted tyrosine kinase inhibitors (TKIs) have been shown to interact with polyspecific organic ...
Yik Pui Tsang, Antonio Jesús López Quiñones, Letícia Salvador Vieira, Joanne Wang   +3 more
doaj   +1 more source

Drug delivery with living cells [PDF]

, 2016
The field of drug delivery has grown tremendously in the past few decades by developing a wide range of advanced drug delivery systems. An interesting category is cell-based drug delivery, which includes encapsulation of drugs inside cells or attached to
Fliervoet, Lies A L, Mastrobattista, Enrico   +1 more
core   +2 more sources

Inflammation Induces Changes in the Functional Expression of P-gp, BCRP, and MRP2: An Overview of Different Models and Consequences for Drug Disposition

Pharmaceutics, 2021
The ATP-binding cassette (ABC) transporters play a key role in drug pharmacokinetics. These membrane transporters expressed within physiological barriers can be a source of pharmacokinetic variability.
Sonia Saib, Xavier Delavenne
doaj   +1 more source