Characterisation and validation of drug transport and GLP-1R function in primary porcine proximal tubular cells [PDF]
, 2006 Overview kidney: Kidney is, beside the liver, one of the most important organs for the elimination of waste products, toxins, drugs and their metabolites. Due to the anatomy of the kidney, ultra filtrate leaving the glomerulus passes first the proximal
Schlatter, Philipp
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Organism-specific differences in the binding of ketoprofen to serum albumin
IUCrJ, 2022 Serum albumin is a circulatory transport protein that has a highly conserved sequence and structure across mammalian organisms. Its ligand-binding properties are of importance as albumin regulates the pharmacokinetics of many drugs.
Mateusz P. Czub +3 more
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Frontiers in Pharmacology, 2021 The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics.
Johannes Matthaei +10 more
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Expression of drug transporters in intestine and blood [PDF]
, 2005 Proteins that are capable to transport molecules across membranes are fundamental for the accurate functioning of the body. Many diseases have their cause in a dysfunction of a particular transport protein.
Zimmermann, Christian
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Investigation of the transport of lipophilic drugs in structurally diverse lipid formulations through caco-2 cell monolayer using mathematical modeling [PDF]
, 2008 Introduction: To be absorbed from the gastrointestinal tract, a drug has to be sufficiently soluble, because, with some exceptions, passive diffusion of dissolved drug molecules from high to low drug concentration is the driving force of drug ...
Schneider, Marcel
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In silico Prioritization of Transporter–Drug Relationships From Drug Sensitivity Screens
Frontiers in Pharmacology, 2018 The interplay between drugs and cell metabolism is a key factor in determining both compound potency and toxicity. In particular, how and to what extent transmembrane transporters affect drug uptake and disposition is currently only partially understood.
Adrián César-Razquin +9 more
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"In vitro" evaluation of blood-brain barrier transport [PDF]
, 2014 The blood-brain barrier (BBB), which is formed by brain capillary endothelial cells, effectively protects the central nervous system (CNS) from potential neurotoxic agents and maintains the brain homeostasis for synaptic signaling (Abbott, 2004 ...
Dieu, Le-Ha
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Enantioselective Drug Recognition by Drug Transporters [PDF]
Molecules, 2018 Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton-coupled folate transporters (PCFT/SLC46A1), organic anion transporting polypeptides (OATPs/SLCO), organic
openaire +3 more sources
Glycerol gelatin for 3D-printing of implants using a paste extrusion technique
Current Directions in Biomedical Engineering, 2017 Fused deposition modeling as an additive manufacturing technique has gained great popularity for the fabrication of medical devices as well as pharmaceutical dosage forms over the last years.
Kempin Wiebke +3 more
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Modeling drug transport within the viable skin - a review
, 2020 In the past, mathematical modeling of the transport of transdermal drugs has been primarily focused on the stratum corneum. However, the development of pharmaceutical technologies, such as chemical enhancers, iontophoresis, and microneedles, has led to ...
Calcutt, JJ +5 more
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