Results 11 to 20 of about 579,008 (311)
Drug transport by red blood cells [PDF]
Frontiers in Physiology, 2023 This review focuses on the role of human red blood cells (RBCs) as drug carriers. First, a general introduction about RBC physiology is provided, followed by the presentation of several cases in which RBCs act as natural carriers of drugs. This is due to
Sara Biagiotti +2 more
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Drug transporters in pharmacokinetics [PDF]
Naunyn-Schmiedeberg's Archives of Pharmacology, 2006 This review deals with the drug transporters allowing drugs to enter and leave cells by carrier-mediated pathways. Emphasis is put on liver transporters but systems in gut, kidney, and blood-brain barrier are mentioned as well. Drug-drug interactions on carriers may provoke significant modification in pharmacokinetics as do carrier gene polymorphisms ...
Ernst, Petzinger, Joachim, Geyer
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Kidney Drug Transporters in Pharmacotherapy
International Journal of Molecular Sciences, 2023 The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug–drug interactions, as well as constituting direct drug targets.
Joanna Łapczuk-Romańska +3 more
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Extracellular Vesicles as Drug Transporters
International Journal of Molecular Sciences, 2023 Extracellular vesicles (EVs) are lipid bilayer-delimited particles. According to their size and synthesis pathway, EVs can be classified into exosomes, ectosomes (microvesicles), and apoptotic bodies. Extracellular vesicles are of great interest to the scientific community due to their role in cell-to-cell communication and their drug-carrying ...
Monika Nowak +4 more
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Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]
, 2014 A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
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In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions
Pharmacology Research & Perspectives, 2022 Fenfluramine (FFA) has potent antiseizure activity in severe, pharmacoresistant childhood‐onset developmental and epileptic encephalopathies (e.g., Dravet syndrome).
Parthena Martin +6 more
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Frontiers in Pharmacology, 2023 SARS-CoV-2-mediated interactions with drug metabolizing enzymes and membrane transporters (DMETs) in different tissues, especially lung, the main affected organ may limit the clinical efficacy and safety profile of promising COVID-19 drugs.
Chukwunonso K. Nwabufo +10 more
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"In silico" prediction of drug transport across physiological barriers [PDF]
, 2011 Physiological barriers maintain and safeguard homeostasis of certain body compartments by an increased resistance against free diffusion. Distribution and pharmacokinetics of drugs can be altered as well, if they have to cross these barriers in order to ...
Suenderhauf, Claudia
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Predicting Viable Skin Concentration: Diffusional and Convective Drug Transport
, 2021 Viable skin drug transport is an important concept to consider as it can have a significant impact on the local concentration of a drug. The concentration becomes even more critical for toxicological issues when implementing different permeability ...
Calcutt, Joshua J, Anissimov, Yuri G
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Influence of Siluron® insertion on model drug distribution in the simulated vitreous body
Current Directions in Biomedical Engineering, 2016 Biorelevant in vitro test systems may be helpful to understand the in vivo behaviour of modern intravitreal dosage forms such as implants and injections.
Stein Sandra +3 more
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